43717-Snyder, Scott

Scott E. Snyder, PhD

Associate Professor of Radiology & Imaging Sciences

Director, Molecular Imaging Ligand Development Program

Adjunct Associate Professor of Chemistry and Chemical Biology, Indiana University—Indianapolis

(317) 278-8710
R2 E124
Indianapolis, IN


Dr. Snyder is an Associate Professor of Radiology and Imaging Sciences. He got his PhD in Medicinal Chemistry from Purdue University, developing novel dopamine receptor agonists under the mentorship of Dr. David Nichols. He joined the Nuclear Medicine Division at the University of Michigan Medical School as a postdoctoral researcher in the laboratory of Dr. Michael Kilbourn, where he trained in PET radiochemistry and imaging. He remained at Michigan for the next 14 years rising to the rank of Associate Research Professor. In 2007 he was recruited to St Jude Children’s Research Hospital to design and direct their new Molecular Imaging Research (MIR) laboratories. He joined the IU School of Medicine in 2019 as Director of the newly established Molecular Imaging Ligand Development Program (MILDP). In his 30+ years as a Nuclear Medicine researcher, Dr. Snyder has gained extensive experience in radiochemistry, radiopharmaceutical design, preclinical PET imaging with rodents and primates and human subjects PET research. He has led or been involved in the translation of two novel radiotracer for human use and preparation of five radiopharmaceutical human use authorizations, including four Investigational New Drug (IND)/IRB applications. He has 17 years of experience as director of a radiochemistry core and research facility, including the design and construction of the MIR laboratories at St Jude (Memphis, TN, 2007-2019) and as director of the MILDP here at the IU School of Medicine (2019-present). The MILDP comprises both the Indiana Institute for Biomedical Imaging Sciences (IIBIS) Radiochemistry Facility and the independent research programs of Dr. Snyder and two other radiochemistry faculty members. His team routinely prepares 6-8 different established PET radiopharmaceuticals for clinical research and preclinical in vivo studies and supports multiple collaborative research projects to design novel radiotracers and imaging methods for positron emission tomography (PET).

Key Publications

Smith NJ, Deaton TK, Territo W, Graner B, Gauger A, Snyder SE, Schulte ML, Green MA, Hutchins GD, Veronesi MC. Hybrid 18F-Fluoroethyltyrosine PET and MRI with Perfusion to Distinguish Disease Progression from Treatment-Related Change in Malignant Brain Tumors: The Quest to Beat the Toughest Cases. J Nucl Med. 2023, 64(7):1087-1092  PMID: 37116915

Snyder SE, Butch ER, Shulkin BL. Radiopharmaceuticals in pediatric nuclear medicine. In: Textbook of Radiopharmaceuticals; Radiochemistry and Applications.  Scott PJ, Kilbourn MR, eds. New York:  John Wiley & Sons, pp 653-701, 2021

Butch ER, Mead PE, Amador-Diaz V, Tillman H, Stewart E, Mishra JK, Kim J, Bahrami A, Dearling JLJ, Packard AB, Stoddard SV, Vavere AL, Han Y, Shulkin BL, Snyder* SE. Positron Emission Tomography Detects In Vivo Expression of Disialoganglioside GD2 in Mouse Models of Primary and Metastatic Osteosarcoma. Cancer Res, 79(12):3112-3124, 2019. PMID: 31015228

Hu B, Vavere AL, Neumann KD, DiMagno SG, Snyder* SE. A Practical, Automated Synthesis of meta-[18F]Fluorobenzylguanidine for Clinical Use. ACS Chem Neurosci, 6(11):1870-1879, 2015; PMID: 26313342

Stewart E, Goshorn R, Bradley C, Griffiths LM, Benavente C, Twarog NR, Miller GM, Caufield W, Freeman BB 3rd, Bahrami A, Pappo A, Wu J, Loh A, Karlström Å, Calabrese C, Gordon B, Tsurkan L, Hatfield MJ, Potter PM, Snyder SE, Thiagarajan S, Shirinifard A, Sablauer A, Shelat AA, Dyer MA. Targeting the DNA repair pathway in Ewing sarcoma. Cell Reports, 9(3):829-841, 2014. PMID: 25437539

Snyder SE, Kilbourn MR. Chemistry of fluorine-18 Radiopharmaceuticals.  In:  Welch MG, Redvanly CS, eds.  Textbook of Radiopharmaceuticals; Radiochemistry and Applications.  New York:  John Wiley & Sons, pp 195-227, 2003

Snyder* SE, Gunupudi N, Sherman PS, Butch ER, Skaddan MB, Kilbourn MR, Koeppe RA, Kuhl DE.  Radiolabeled cholinesterase substrates:  In vitro methods for determining structure-activity relationships and identification of a positron emission tomography radiopharmaceutical for in vivo measurement of butyrylcholinesterase activity.  J Cereb Blood Flow Metab 21:132-143, 2001. PMID: 11176278

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