Signaling pathways controlling Schwann cell proliferation and differentiation
Monje PV, Bunge MB, Wood PM (2006) Cyclic AMP synergistically enhances neuregulin-dependent ERK and Akt activation and cell cycle progression in Schwann cells. Glia 53(6):649-659.
Monje PV, Athauda G, Wood PM (2008) PKA-mediated gating of neuregulin-dependent ERBB2-ERBB3 activation underlies the synergistic action of cAMP on Schwann cell proliferation. J. Biol. Chem. 283(49):34087-100.
Monje PV, Rendon S, Athauda G, Bates M, Wood PM, Bunge MB (2009) Non-antagonistic relationship between mitogenic factors and cAMP in adult Schwann cell re-differentiation. Glia 57:947-961.
Monje PV, Soto J, Bacallao K, Wood PM (2010) Schwann cell dedifferentiation is independent of mitogenic signaling and uncoupled to proliferation: role of cAMP and JNK in the maintenance of the differentiated state. J. Biol. Chem. 285:31024-36.
Bacallao K, Monje PV (2013) Opposing roles of PKA and EPAC in the cAMP-dependent regulation of Schwann cell proliferation and differentiation. PLoS One 8 (12): e82354.
Bacallao K, Monje PV (2015) Requirement of cAMP signaling for Schwann cell differentiation restricts the onset of myelination. PLoS One 10 (2): e0116948.
Monje PV (2015) To myelinate or not to myelinate: Fine tuning cAMP signaling in Schwann cells to balance cell proliferation and differentiation. Neural Regeneration Research 10 (12): 1936-1937. PMID: 26889176.
Camarena V, Sant DW, Huff TC, Mustafi S, Muir RK, Aron AT, Chang CJ, Renslo AR, Monje PV, Wang G. (2017) Cyclic adenosine monophosphate to play a novel role in regulating DNA demethylation and gene transcription by augmenting the intracellular reactive Fe(II) pool. eLIFE, 1-21.
Piñero G, Berg R, Andersen N, Setton-Avruj P, Monje P.V. (2017) Lithium reversibly inhibits Schwann cell proliferation and differentiation without inducing myelin loss. Mol. Neurobiol. 54 (10): 8287-8307.
Soto, J, Monje, P.V. (2017) Axon-contact driven Schwann cell dedifferentiation. Glia 65 (6), 864-882.
Development of new methods and assays to study Schwann cells
Andersen N, Srinivas S, Piñero G, Monje P.V. (2016) A rapid and versatile method for the isolation, purification and cryogenic storage of Schwann cells from adult rodent nerves. Scientific Reports 6, 31781.
Monje P.V. (2018) Scalable neuron-free assays for the differentiation and dedifferentiation of cultured Schwann cells. Methods Mol. Biol. 1739: 213-232.
Andersen N.D., Monje P.V. (2018) Isolation, culture and cryopreservation of adult rodent Schwann cells derived from immediately dissociated teased fibers. Meth. Mol. Biol. 1739: 49-66.
Ravelo K.M., Andersen N.D., Monje P.V. (2018) Magnetic-activated cell sorting for the fast and efficient separation of human and rodent Schwann cells from mixed cell populations. Meth. Mol. Biol. 1739: 87-109.
Monje P.V, Sant D, Wang G. (2018) Phenotypic and functional characteristics of human Schwann cells as revealed by cell-based assays and RNA-seq. Mol. Neurobiol. 55 (8):6637-6660.
Uses of Schwann cells in cell therapy
Bunge M.B., Monje P.V., Khan A. and Wood P.M. (2017). From transplanting Schwann cells in experimental rat spinal cord injury to their transplantation into human injured spinal cord in clinical trials. Prog Brain Res. 231:107-133. PMID: 28554394
Link to publications list
For a reference to Schwann cell methods
Monje P.V., Kim H.A. (Eds). (2018) Schwann cells: methods and protocols. 1st Ed. In: Methods Mol. Biol. 1739, XIII - 488 (31 chapters). ISBN: 978-1-4939-7648-5 (hardcover), 978-1-4939-7649-2 (eBook).
For a reference to Schwann cell products