43427-Yu, Tao

Tao Yu, PhD

Assistant Research Professor of Medical & Molecular Genetics

(317) 737-5902
R3 C260
Indianapolis, IN



Dr. Yu obtained his Ph.D. from the Institute Pasteur of Shanghai, where his studies were primarily focused on elucidating the role of host metabolism in regulating the infectious cycle of the hepatitis C virus. After completing his Ph.D., Dr. Yu pursued postdoctoral studies at Indiana University School of Medicine from 2018 to 2023. Subsequently, he transitioned into the role of an assistant research professional in the Department of Medical and Molecular Genetics. Dr. Yu's research interests are diverse and revolve around the field of cancer research. He is particularly enthusiastic about investigating oncolytic viruses, cancer cell metabolism, and immunometabolism. Currently, his research is primarily focused on identifying metabolic targets through the use of bioinformatical tools, in vitro screening methods, and cell/animal models for the advancement of tumor-targeted therapy and immunotherapy.


2023 IUSM Postdoctral Travel Award.

2022 1st Place Award of poster presentation in translational research, Cancer Research Day, The Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis.

2022 Best Paper Award, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis.

2016 HCV 2016 Fellowship, 23rd International Symposium on HCV and Related Viruses, Kyoto.


Professional Organizations

Associate Member, American Association for Cancer Research

Key Publications

Achreja A, Yu T (co-first), Mittal A, Choppara S, Animasahun O, Nenwani M, Wuchu F, Meurs N, Mohan A, Jeon JH, Sarangi I, Jayaraman A, Owen S, Kulkarni R, Cusato M, Weinberg F, Kweon HK, Subramanian C, Wicha MS, Merajver SD, Nagrath S, Cho KR, DiFeo A, Lu X, Nagrath D. Metabolic collateral lethal target identification reveals MTHFD2 paralogue dependency in ovarian cancer. Nat Metab. 2022 Sep;4(9):1119-1137

Yu T, Dong T, Eyvani H, Fang Y, Wang X, Zhang X, Lu X. Metabolic interventions: a new insight into the cancer immunotherapy. Arch Biochem Biophys. 2021 Jan 15;697:108659

Yu T, Yang Q, Tian, F, Chang H, Hu Z, Yu B, Han L, Xing Y, Jiu Y, He Y, Zhong J. Glycometabolism regulates hepatitis C virus release. PLoS Pathog. 2021 Jul 23;17(7):e1009746

Van der Jeught K, Sun Y, Fang Y, Zhou Z, Jiang H, Yu T, Yang J, Kamocka MM, So KM, Li Y, Eyvani H, Sandusky GE, Frieden M, Braun H, Beyaert R, He X, Zhang X, Zhang C, Paczesny S, Lu X. ST2 as checkpoint target for colorectal cancer immunotherapy. JCI Insight. 2020 May 7;5(9):e136073

Cao L, Yu B, Kong D, Cong Q, Yu T, Chen Z, Hu Z, Chang H, Zhong J, Baker D, He Y. Functional expression and characterization of the envelope glycoprotein E1E2 heterodimer of hepatitis C virus. PLoS Pathog. 2019; 15:e1007759

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