Joshua R. Huot, PhD

Key Publications

Huot JR, Pin F, Chatterjee R, Bonetto A. PGC1α overexpression preserves muscle mass and function in cisplatin-induced cachexia. J Cachexia Sarcopenia Muscle. 2022 Jul 28;. doi: 10.1002/jcsm.13035. [Epub ahead of print] PubMed PMID: 35903870.

Pin F, Jones AJ, Huot JR, Narasimhan A, Zimmers TA, Bonewald LF, Bonetto A. RANKL Blockade Reduces Cachexia and Bone Loss Induced by Non-Metastatic Ovarian Cancer in Mice. J Bone Miner Res. 2022 Mar;37(3):381-396. doi: 10.1002/jbmr.4480. Epub 2021 Dec 13. PubMed PMID: 34904285; PubMed Central PMCID: PMC8940654.

Huot JR, Pin F, Bonetto A. Muscle weakness caused by cancer and chemotherapy is associated with loss of motor unit connectivity. Am J Cancer Res. 2021;11(6):2990-3001. eCollection 2021. PubMed PMID: 34249440; PubMed Central PMCID: PMC8263661.

Kim HG, Huot JR, Pin F, Guo B, Bonetto A, Nader GA. Reduced rDNA transcription diminishes skeletal muscle ribosomal capacity and protein synthesis in cancer cachexia. FASEB J. 2021 Feb;35(2):e21335. doi: 10.1096/fj.202002257R. PubMed PMID: 33527503; PubMed Central PMCID: PMC7863588.

Huot JR, Pin F, Narasimhan A, Novinger LJ, Keith AS, Zimmers TA, Willis MS, Bonetto A. ACVR2B antagonism as a countermeasure to multi-organ perturbations in metastatic colorectal cancer cachexia. J Cachexia Sarcopenia Muscle. 2020 Dec;11(6):1779-1798. doi: 10.1002/jcsm.12642. Epub 2020 Nov 16. PubMed PMID: 33200567; PubMed Central PMCID: PMC7749603.

Huot JR, Novinger LJ, Pin F, Narasimhan A, Zimmers TA, O'Connell TM, Bonetto A. Formation of colorectal liver metastases induces musculoskeletal and metabolic abnormalities consistent with exacerbated cachexia. JCI Insight. 2020 May 7;5(9). doi: 10.1172/jci.insight.136687. PubMed PMID: 32298240; PubMed Central PMCID: PMC7253026.