43219-Xuan, Yi

Yi Xuan, PhD

Assistant Professor of Surgery

Email xuan@iu.edu
Phone 317-278-3440
975 W. Walnut St.

Indianapolis, IN 46202


Dr. Xuan is an Assistant Professor of Surgery at Indiana University School of Medicine. He received his PhD in Material Science from Tokyo Institute of Technology, Japan. After graduation, he joined the National Institute of Advanced Industrial Science and Technology (AIST) in Tsukuba, where he worked on a national project to develop 45nm Si CMOS HKMG.

Currently, Dr. Xuan is an investigator with the Indiana Center for Regenerative Medicine and Engineering at the IU School of Medicine, where his research focuses on developing the next generation of tissue nanotransfection (TNT) devices, nanochips for exosome detection, and novel biochips for wound healing applications.

Prior to joining IU School of Medicine, he worked at Purdue University on various projects such as nanofabrication, nanoelectronics and nanophotonics. He has authored and co-authored in more than 100 publications including Science, Nature Nanotechnology, Nature Photonics and Nature Communications with 10,000+ citations.

Key Publications

  1. Xuan Y, Ghatak S, Clark A, Li Z, Khanna S, Pak D, Agarwal M, Roy S, Duda P, Sen CK. Fabrication and use of silicon hollow-needle arrays to achieve tissue nanotransfection in mouse tissue in vivo. Nature Protocols, 16, 5707-5738 (2021),https://doi.org/10.1038/s41596-021-00631-0
  2. Xuan Y, Liu Y, Varghese LT, Metcalf AJ, Xue X, Wang PH, Han K, Jaramillo-Villegas JA, Noman AA, Wang C, Kim S, Teng M, Lee YJ, Niu B, Fan L, Wang J, Leaird DE, Weiner AM, Qi M. High-Q silicon nitride microresonators exhibiting low-power frequency comb initiation. Optica, 3(11), 1171-1180 (2016), https://doi.org/10.1364/OPTICA.3.001171
  3. Xue X, Xuan Y, Liu Y, Wang PH, Chen S, Wang J, Leaird DE, Qi M, Weiner AM. Mode-locked dark pulse Kerr combs in normal-dispersion microresonators. Nature Photonics, 9, 594-600 (2015), https://doi.org/10.1038/nphoton.2015.137
  4. Gao H, Hu Y, Xuan Y, Li J, Yang Y, Martinez RV, Li C, Luo J, Qi M, Cheng GJ. Large-scale nanoshaping of ultrasmooth 3D crystalline metallic structures, Science, 346, 1352-1356 (2014) DOI: 10.1126/science.1260139
  5. Xuan Y, Wu YQ, Ye PD. High-Performance Inversion-Type Enhancement-Mode InGaAs MOSFET With Maximum Drain Current Exceeding 1 A/mm. IEEE Electron Device Letters, 29, 294-296 (2008) DOI: 10.1109/LED.2008.917817

Titles & Appointments

  • Assistant Professor of Surgery
  • Associate Director, Biomedical Engineering, Indiana Center for Regenerative Medicine and Engineering
  • Assistant Professor, Weldon School of Biomedical Engineering, Purdue University
  • Education
    2001 PhD Tokyo Institute of Technology
    1997 MS East China University of Science and Technology
    1994 BS East China University of Science and Technology
  • Research

    My lab is dedicated to the implementation of the evolving nanotechnology-based approach to design and fabricate biochips for health care applications.

    Tissue Nanotransfection (TNT): My lab uses computational simulation to investigate TNT mechanisms at the nanoscale, and we design and fabricate the next generation of TNT nanochips for pre-clinical and clinical applications.

    Exosome detection: My lab also designs and manufactures nanophotonics devices for detecting exosome biomarkers for point-of-care clinical applications in wound healing and regenerative medicine.

    Active Grants: 

    NIH/K25 GM143572 (PI)

    Google Scholar

  • Professional Organizations
    Institute of Electrical and Electronics Engineers
    The Optical Society

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