Bio
Dr. Singh currently serves as Assistant Professor of Surgery, Division of Plastic Surgery, Department of Surgery at Indiana University. Dr. Singh received his doctoral degree in Biotechnology from Banaras Hindu University, India. Prior to joining Indiana University, Dr. Singh completed his post-doctoral research at The Ohio State University. Dr. Singh’s research focus is on epigenetic mechanisms of gene expression during diabetic vasculopathy and includes single-cell transcriptomics and single-cell ATAC sequencing approaches to investigate the molecular pathways that are compromised. Dr. Singh served as contributor to more than 40 peer reviewed publications.
Key Publications
Singh K*, Rustagi Y, Abouhashem AS, Tabasum S, Verma P, Hernandez E, Pal D, Khona DK, Mohanty SK, Kumar M, Srivastava R, Guda PR, Verma SS, Mahajan S, Killian JA, Walker LA, Ghatak S, Mathew-Steiner SS, Wanczyk K, Liu S, Wan J, Yan P, Bundschuh R, Khanna S, Gordillo GM, Murphy MP, Roy S and Sen CK*. Genome-wide DNA hypermethylation opposes healing in chronic wound patients by impairing epithelial-to-mesenchymal transition. J Clin Invest. 2022;132(17):e157279. (*co-corresponding authors).
Rustagi Y, Abouhashem AS, Verma P, Verma SS, Hernandez E, Liu S, Kumar M, Guda PR, Srivastava R, Mohanty SK, Kacar S, Mahajan S, Wanczyk KE, Khanna S, Murphy MP, Gordillo GM, Roy S, Wan J, Sen CK, Singh K. Endothelial Phospholipase Cγ2 Improves Outcomes of Diabetic Ischemic Limb Rescue Following VEGF Therapy. Diabetes. 2022 May 1;71(5):1149-1165.
Singh K, Sinha M, Pal D, Tabasum S, Gnyawali SC, Kona D, Sarkar S, Mohanty SK, Soto-Gonzalez F, Khanna S, Roy S, Sen CK. Cutaneous epithelial to mesenchymal transition activator ZEB1 regulates wound angiogenesis and closure in a glycemic status dependent manner. Diabetes 2019, Nov;68(11):2175-2190.
Singh K, Pal D, Sinha M, Ghatak S, Gyawali S, Khanna S, Roy S, Sen CK. (2017) Epigenetic modification of microRNA-200b contributes to diabetic vasculopathy. Molecular Therapy. Molecular Therapy. 25 (12), 2689-2704.
Sinha M, Sen CK, Singh K, Das A, Ghatak S, Rhea B, Blackstone B, Powell H, Khanna S, Roy S. Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue. Nature Communications 2018; 9 (1): 936.
Gallego-Perez D, Pal D, Ghatak S, Malkoc V, Higuita-Castro N, Gnyawali S, Chang L, Liao WC, Shi J, Sinha M, Singh K, Steen E, Sunyecz A, Stewart R, Moore J, Ziebro T, Northcutt RG, Homsy M, Bertani P, Lu W, Roy S, Khanna S, Rink C, Sundaresan VB, Otero JJ, Lee LJ and Sen CK. Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue. Nat Nanotechnol. 2017;12:974-979.
Titles & Appointments
- Assistant Professor of Surgery
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Education
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Research
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Professional Organizations