43044-Moon, Younghye

Younghye Moon, PhD

Assistant Research Professor of Medical & Molecular Genetics

320 West 15th Street, NB 108C

Indianapolis, IN 46202


Dr. Moon received her MS and PhD in neuroscience from Seoul National University in South Korea. Her graduate work focused on understanding the selective cell death mechanisms of dopaminergic neurons in Parkinson’s disease and investigating the migration of adult neural progenitor cells within the neurogenic niche. During post-doctoral training at the University of Miami Miller School of Medicine, Dr. Moon studied the roles of nitric oxide signaling in skeletal muscle. After completing a postdoctoral fellowship in the Department of Neuroscience at the Mayo Clinic (Jacksonville, FL), Dr. Moon joined the Department of Medical and Molecular Genetics at the Indiana University School of Medicine in 2018, working in the laboratory of Dr. Jungsu Kim as research faculty. Dr. Moon’s research is centered on understanding the molecular mechanisms of aging-related neurodegenerative diseases such as Alzheimer’s disease and cell type-specific functions of microRNAs in the pathological condition of the brain.

Key Publications

Moon Y, Balke JE, Madorma D, Siegel MP, Knowels G, Brouckaert P, Buys ES, Marcinek DJ, Percival JM (2017). Nitric oxide regulates skeletal muscle fatigue, fiber type, microtubule organization and mitochondrial ATP synthesis efficiency through cGMP-dependent mechanisms. Antioxid Redox Signal. 26:966-985. http://www.ncbi.nlm.nih.gov/pubmed/27393340

Moon Y, Cao Y, Zhu J, Xu Y, Balkan W, Buys ES, Diaz F, Kerrick WG, Hare JM, Percival JM (2017). GSNOR deficiency enhances in situ skeletal muscle strength, fatigue resistance and RyR1 S-nitrosylation without impacting mitochondrial content and activity. Antioxid Redox Signal. 26:165-181. http://www.ncbi.nlm.nih.gov/pubmed/27412893

Moon Y, Kim JY, Kim WR, Kim HJ, Kim K, Kim H, Sun W (2013). Function of ezrin-radixin-moesin proteins in migration of subventricular zone-derived neuroblasts following traumatic brain injury.  Stem Cells. 31:1696-705. http://www.ncbi.nlm.nih.gov/pubmed/23649635

Moon Y, Kim JY, Choi SY, Cho HM, Kim H, Sun W (2012). Expression of ezrin in subventricular zone neural stem cells and their progeny in adult and developing mice. Histochem Cell Biol. 139:403-13. http://www.ncbi.nlm.nih.gov/pubmed/23229862

Moon Y, Kim H, Sun W (2012). Characterization of embryonic cortical neuronal death in prolonged cell suspension. Neurosci Lett. 531:155-9. http://www.ncbi.nlm.nih.gov/pubmed/23127849

Moon Y, Kim HJ, Kim JY, Kim H, Kim WR, Sun W (2011). Different expression of human GFAP promoter-derived GFP in different subsets of astrocytes in the mouse brain. Animal Cells Syst. 15:268-273. http://www.tandfonline.com/doi/full/10.1080/19768354.2011.611254.

Moon Y, Kim JY, Choi SY, Kim K, Kim H, Sun W (2011). Induction of ERM molecules following cryogenic traumatic brain injury of the mouse cortex. Neuroreport. 22:304-8. http://www.ncbi.nlm.nih.gov/pubmed/21451358

Sun W, Kim H, Moon Y (2010). Control of neuronal migration through rostral migratory stream in mice. Anat Cell Biol. 43:269-79. http://www.ncbi.nlm.nih.gov/pubmed/21267400

Moon Y, Choi SY, Kim K, Kim H, Sun W (2010). Expression of connexin29 and 32 in the penumbra region after traumatic brain injury of mice. Neuroreport. 21:1135-9. http://www.ncbi.nlm.nih.gov/pubmed/20926974

Lee SY*, Moon Y*, Choi DH, Choi HJ, Hwang O (2007). Particular vulnerability of rat
mesencephalic dopaminergic neurons to tetrahydrobiopterin: Relevance to Parkinson's disease.
NeurobiolDis. 25:112-20
(*: equal contributor). http://www.ncbi.nlm.nih.gov/pubmed/17049260

Moon Y, Lee KH, Park JH, Geum D, Kim K (2005). Mitochondrial membrane depolarization  and the selective death of dopaminergic neurons by rotenone: protective effect of coenzyme Q10. J Neurochem. 93:1199-208. http://www.ncbi.nlm.nih.gov/pubmed/15934940

Titles & Appointments

  • Assistant Research Professor of Medical & Molecular Genetics
  • Education
    2012 PhD Seoul National University
    2004 MS Seoul National University
    2002 BS Daejeon University

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