Bio
Dr. Ghatak currently serves as an Assistant Professor of Surgery at the Indiana Center for Regenerative Medicine and Engineering. Dr. Ghatak received his doctoral degree in Biochemistry from West Bengal University of Health Sciences, India, on the mechanisms of liver injury and repair in xenobiotic-induced toxicity.
Before joining Indiana University, Dr. Ghatak did his post-doctoral Research at The Ohio State University, Columbus on the mechanism of tissue plasticity and the role of microRNA that contributes to regenerative healing in adults. He was actively involved in the development of a novel non-invasive non-viral tissue nanotransfection platform that can reprogram skin fibroblasts to functional neural and endothelial-like cells.
Dr. Ghatak’s research focus is on the application of nanotechnology in regenerative medicine with specific interest in exosomes and tissue nanotransfection. He has served as principal investigator for an NIH-funded R56 grant. He has contributed to 30 peer-reviewed publications.
Grant Funding
NIH/NIDDK (1R56DK129592) Principal Investigator
IU-CTSI (TL1TR000162-05) Co-Investigator
Key Publications
- Zhou X, Brown BA, Siegel AP, El Masry MS, Zeng X, Song W, Das A, Khandelwal P, Clark A, Singh K, Guda PR, Gorain M, Timsina L, Xuan Y, Jacobson SC, Novotny MV, Roy S, Agarwal M, Lee RJ, Sen CK, Clemmer DE, Ghatak S.*. Exosome-mediated Crosstalk between Keratinocytes and Macrophages in Cutaneous Wound Healing. ACS Nano. 2020. 14(10):12732-12748.PMID: 32931251 (*co-corresponding author).
- Li J, Ghatak S†, El-Masry M, Das A, Liu Y, Roy S, Lee RJ, Sen CK. Topical Lyophilized Targeted Lipid-Nanoparticles in the Restoration of Skin Barrier Function Following Burn Wound. Mol Ther. 26(9):2178-2188. PMID: 29802017 († co-first author).
- Ahmed NS, Ghatak S†, El-Masry M, Gnyawali SC, Roy S, Amer M, Everts H, Sen CK, Khanna S. Epidermal E-cadherin dependent β-catenin pathway is phytochemical-inducible and accelerates anagen hair cycling. Mol Ther. 25(11):2502-2512. PMID: 28803863(† co-first author).
- Gallego-Perez D, Pal D, Ghatak S†, Malkoc V, Gnyawali S, Chang L, Liao WC, Shi J, Sinha M, Steen E, Sunyecz A, Stewart R, Homsy M, Lu W, Khanna S, Rink C, Otero JJ, Lee JL, Sen CK. Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue. Nat Nanotechnol. 12(10):974-979. PMID: 28785092(† co-first author).
- Ghatak S, Li J, Chan YC, Gnyawali SC, Steen E, Yung BC, Khanna S, Roy S, Lee RJ, Sen CK. AntihypoxamiR functionalized gramicidin lipid nanoparticles rescues against ischemic memory improving cutaneous wound healing. Nanomedicine. 2016; 12(7):1827-1831. PMID: 27033464
- Ghatak S, Chan YC, Khanna S, Banerjee J, Weist J, Roy S, Sen CK. Barrier function of the repaired skin is disrupted following arrest of dicer in keratinocytes. Mol Ther. 2015; 23(7):1201-10. PMID: 25896246
Titles & Appointments
- Assistant Professor of Surgery
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Education
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Research
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Professional Organizations