42920-Ghatak, Subhadip
Faculty

Subhadip Ghatak, PhD

Assistant Professor of Surgery

Phone 317-278-2711
Address
975 W Walnut St.
IB 444D

Indianapolis, IN 46202

Bio

Dr. Ghatak currently serves as an Assistant Professor of Surgery at the Indiana Center for Regenerative Medicine and Engineering. Dr. Ghatak received his doctoral degree in Biochemistry from West Bengal University of Health Sciences, India, on the mechanisms of liver injury and repair in xenobiotic-induced toxicity.

Before joining Indiana University, Dr. Ghatak did his post-doctoral Research at The Ohio State University, Columbus on the mechanism of tissue plasticity and the role of microRNA that contributes to regenerative healing in adults. He was actively involved in the development of a novel non-invasive non-viral tissue nanotransfection platform that can reprogram skin fibroblasts to functional neural and endothelial-like cells.

Dr. Ghatak’s research focus is on the application of nanotechnology in regenerative medicine with specific interest in exosomes and tissue nanotransfection. He has served as principal investigator for an NIH-funded R56 grant. He has contributed to 30 peer-reviewed publications.

Grant Funding 

NIH/NIDDK (1R56DK129592)   Principal Investigator

 

IU-CTSI (TL1TR000162-05)    Co-Investigator

Key Publications

  1. Zhou X, Brown BA, Siegel AP, El Masry MS, Zeng X, Song W, Das A, Khandelwal P, Clark A, Singh K, Guda PR, Gorain M, Timsina L, Xuan Y, Jacobson SC, Novotny MV, Roy S, Agarwal M, Lee RJ, Sen CK, Clemmer DE, Ghatak S.*. Exosome-mediated Crosstalk between Keratinocytes and Macrophages in Cutaneous Wound Healing. ACS Nano. 2020. 14(10):12732-12748.PMID: 32931251 (*co-corresponding author).
  2. Li J, Ghatak S, El-Masry M, Das A, Liu Y, Roy S, Lee RJ, Sen CK. Topical Lyophilized Targeted Lipid-Nanoparticles in the Restoration of Skin Barrier Function Following Burn Wound. Mol Ther. 26(9):2178-2188. PMID: 29802017 (co-first author).
  3. Ahmed NS, Ghatak S, El-Masry M, Gnyawali SC, Roy S, Amer M, Everts H, Sen CK, Khanna S. Epidermal E-cadherin dependent β-catenin pathway is phytochemical-inducible and accelerates anagen hair cycling. Mol Ther. 25(11):2502-2512. PMID: 28803863(co-first author).
  4. Gallego-Perez D, Pal D, Ghatak S, Malkoc V, Gnyawali S, Chang L, Liao WC, Shi J, Sinha M, Steen E, Sunyecz A, Stewart R, Homsy M, Lu W, Khanna S, Rink C, Otero JJ, Lee JL, Sen CK. Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue. Nat Nanotechnol. 12(10):974-979. PMID: 28785092(co-first author).
  5. Ghatak S, Li J, Chan YC, Gnyawali SC, Steen E, Yung BC, Khanna S, Roy S, Lee RJ, Sen CK. AntihypoxamiR functionalized gramicidin lipid nanoparticles rescues against ischemic memory improving cutaneous wound healing. Nanomedicine. 2016; 12(7):1827-1831. PMID: 27033464
  6. Ghatak S, Chan YC, Khanna S, Banerjee J, Weist J, Roy S, Sen CK. Barrier function of the repaired skin is disrupted following arrest of dicer in keratinocytes. Mol Ther. 2015; 23(7):1201-10. PMID: 25896246  

Titles & Appointments

  • Assistant Professor of Surgery
  • Education
    2018 FEL The Ohio State University, Department of Surgery
    2011 PhD West Bengal University of Health Sciences
    2003 MSC University of Calcutta
    2001 BS University of Calcutta
  • Research

    Dr. Ghatak’s laboratory at the Indiana Center for Regenerative Medicine and Engineering (ICRME) focuses on exosome-mediated cell-cell crosstalk in tissue regeneration and repair and the role of miRNA in wound healing.

    Exosome-mediated cell-cell crosstalk in tissue regeneration and repair. Dr. Ghatak’s laboratory is investigating the cellular crosstalk between the different cell types in cutaneous wound healing. Efficient wound healing and resolution of inflammation relies on successful crosstalk via exosomes between the resident keratinocytes and blood-borne wound-site macrophages. Dr. Ghatak developed specialized genetic tools for cell-specific labeling of exosomes to study the significance of cell-cell crosstalk in tissue regeneration and repair. Dr. Ghatak has active collaboration with Dr. David Clemmer of the Department of Chemistry at IU Bloomington. Dr. Ghatak’s collaboration with Dr. Clemmer has led to the first publication of the charge-detection mass spectrometry (CDMS) spectrum of keratinocyte-originated exosomes (in the 10 to 100 MDa regime).

    Role of miRNA in wound healing. Tissue repair and regeneration rely on the function of miRNA, molecular silencers that enact post-transcriptional gene silencing of coding genes. Dr. Ghatak’s work is primarily focused on understanding the significance of the microRNAs that are muted during fetal development. His work is mostly focused on miR-200b, miR-29, miR-107 and miR-210 (master hypoxamiR). For example, miR-210 abundance at the wound-edge impairs wound healing. Dr. Ghatak developed functionalized targeted lipid nanoparticles that can be used to sequester miR-210 to improve cutaneous wound healing.


    Google Scholar 

  • Professional Organizations
    American Association for Advancement of Science
    American Association of Extracellular Vesicles
    American Society for Exosomes and Microvesicles
    International Society for Extracellular Vesicles
    Wound Healing Society

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