42748-Sen, Chandan
Faculty

Chandan K. Sen, MS, PhD

Associate Vice President of Military & Applied Research

Email cksen@iu.edu
Address
975 W Walnut St.
IB Building, Suite 400

Indianapolis, IN 46202

Bio

Dr. Chandan K. Sen is a J. Stanley Battersby Chair and Professor of Surgery, Director of the Indiana Center for Regenerative Medicine and Engineering (ICRME), and Executive Director of the Comprehensive Wound Care Center at IU Methodist Hospital. At IU, he serves as Associate Vice President of Research. At the IU School of Medicine, he serves as Associate Dean of Research. At Indiana University Health, Dr. Sen is the Executive Director of the Comprehensive Wound Center.  Dr. Sen is recognized as a Lilly INCITE scholar.

After completing his Masters of Science in Human Physiology from the University of Calcutta, Dr. Sen received his PhD in Physiology from the University of Eastern Finland. Dr. Sen trained as a postdoctoral fellow at the University of California at Berkeley's Molecular and Cell Biology department. His first faculty appointment was in the Lawrence Berkeley National Laboratory.

In 2000, Dr. Sen moved to The Ohio State University where he was tenured John H & Mildred C Lumley Professor of Surgery, Executive Director of The Ohio State University Comprehensive Wound Center and Director of the Ohio State University's Center for Regenerative Medicine & Cell Based Therapies. Dr. Sen's primary areas of research interest include tissue injury, repair, regeneration, and infection. His group has pioneered the Tissue Nanotransfection (TNT) technology in regenerative medicine and received the 2018 Edison Award for Innovation. Dr. Sen's work has also led to electroceutical management of tissue infection. In 2016, this technology received the Frost & Sullivan award for new product innovation. In 2022, Dr. Sen was elected as Fellow of the National Academy of Inventors. Dr. Sen has published more than 300 peer reviewed publications and a dozen books which are currently cited more than 44,000 times in literature.

Key Publications

Titles & Appointments

  • Associate Vice President of Military & Applied Research
  • Associate Dean for Entrepreneurial Research
  • Distinguished Professor
  • J. Stanley Battersby Professor of Surgery
  • Adjunct Professor of Anatomy, Cell Biology & Physiology
  • Adjunct Professor, Community and Health Systems, School of Nursing
  • Director, Indiana Center for Regenerative Medicine and Engineering
  • Vice Chair of Research, Department of Surgery
  • Executive Director, IU Health Comprehensive Wound Center
  • Associate Director, Indiana Clinical and Translational Sciences Institute
  • Lilly Endowment INCITE Scholar
  • Education
    1996 FEL University of California, Berkley
    1994 PhD University of Eastern Finland
    1990 MS University of Calcutta
    1987 BS University of Calcutta
  • Research

    Tissue Nanotransfection Platform

    1. Singh K, Rustagi Y, Abouhashem AS, Tabasum S, Verma P, Hernandez E, Pal D, Khona DK, Mohanty SK, Kumar M, Srivastava R, Guda PR, Verma SS, Mahajan S, Killian JA, Walker LA, Ghatak S, Mathew-Steiner SS, Wanczyk KE, Liu S, Wan J, Yan P, Bundschuh R, Khanna S, Gordillo GM, Murphy MP, Roy S, Sen CK. Genome-wide DNA hypermethylation opposes healing in patients with chronic wounds by impairing epithelial-mesenchymal transition. J Clin Invest. 2022 Sep 1;132(17):e157279.
    2. Li Z,Xuan Y,Ghatak S,Guda PR, Roy S and Sen CK. Modeling the gene delivery process of the needle array-based tissue nanotransfection. Nano Research. 2022; 15,  3409–3421
    3. Xuan Y, Ghatak S, Clark A, Li Z, Khanna S, Pak D, Agarwal M, Roy S, Duda P, Sen CK. Fabrication and use of silicon hollow-needle arrays to achieve tissue nanotransfection in mouse tissue in vivo. Nat Protoc. 2021 Dec;16(12):5707-5738.
    4. Moore JT, Wier CG, Lemmerman LR, Ortega-Pineda L, Dodd DJ, Lawrence WR, Duarte-Sanmiguel S, Dathathreya K, Diaz-Starokozheva L, Harris HN, Sen CK, Valerio IL, Higuita-Castro N, Arnold WD, Kolb SJ, Gallego-Perez D. Nanochannel-Based Poration Drives Benign and Effective Nonviral Gene Delivery to Peripheral Nerve Tissue. Adv Biosyst. 2020 Nov;4(11):e2000157. 
    5. Gallego-Perez D, Pal D, Ghatak S, Malkoc V, Higuita-Castro N, Gnyawali S, Chang L, Liao WC, Shi J, Sinha M, Singh K, Steen E, Sunyecz A, Stewart R, Moore J, Ziebro T, Northcutt RG, Homsy M, Bertani P, Lu W, Roy S, Khanna S, Rink C, Sundaresan VB, Otero JJ, Lee LJ, Sen CK. Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue. Nat Nanotechnol. 2017 Oct;12(10):974-979. 

     

    Electroceutical Infection Management

    1. Ghatak S, Khona DK, Sen A, Huang K, Jagdale G, Singh K, Gopalakrishnan V, Cornetta KG, Roy S, Khanna S, Baker LA, Sen CK. Electroceutical fabric lowers zeta potential and eradicates coronavirus infectivity upon contact. Sci Rep. 2021 Nov 5;11(1):21723.
    2. Khona DK, Roy S, Ghatak S, Huang K, Jagdale G, Baker LA, Sen CK. Ketoconazole resistant Candida albicans is sensitive to a wireless electroceutical wound care dressing. 2021 Dec;142:107921.
    3. Barki KG, Das A, Dixith S, Ghatak PD, Mathew-Steiner S, Schwab E, Khanna S, Wozniak DJ, Roy S, Sen CK. Electric Field Based Dressing Disrupts Mixed-Species Bacterial Biofilm Infection and Restores Functional Wound Healing. Ann Surg. 2019 Apr;269(4):756-766. 
    4. Banerjee J, Das Ghatak P, Roy S, Khanna S, Hemann C, Deng B, Das A, Zweier JL, Wozniak D, Sen CK. Silver-zinc redox-coupled electroceutical wound dressing disrupts bacterial biofilm. PLoS One. 2015 Mar 24;10(3):e0119531. 

     

    Diabetic Wound Healing

    1. Singh K, Sinha M, Pal D, Tabasum S, Gnyawali SC, Khona D, Sarkar S, Mohanty SK, Soto-Gonzalez F, Khanna S, Roy S, Sen CK. Cutaneous Epithelial to Mesenchymal Transition Activator ZEB1 Regulates Wound Angiogenesis and Closure in a Glycemic Status Dependent Manner. Diabetes. 2019 Nov;68(11):2175-2190.
    2. Das A, Abas M, Biswas N, Banerjee P, Ghosh N, Rawat A, Khanna S, Roy S, Sen CK. A Modified Collagen Dressing Induces Transition of Inflammatory to Reparative Phenotype of Wound Macrophages. Sci Rep. 2019 9(1):14293.
    3. Singh K, Pal D, Sinha M, Ghatak S, Gnyawali SC, Khanna S, Roy S, Sen CK. Epigenetic Modification of MicroRNA-200b Contributes to Diabetic Vasculopathy. Mol Ther. 2017 25(12):2689-2704.
    4. Das A, Ghatak S, Sinha M, Chaffee S, Ahmed NS, Parinandi NL, Wohleb ES, Sheridan JF, Sen CK, Roy S. Correction of MFG-E8 Resolves Inflammation and Promotes Cutaneous Wound Healing in Diabetes. J Immunol. 2016. 196(12):5089-100.

     

    Multiomics and Bioinformatics

    1. Rustagi Y, Abouhashem AS, Verma P, Verma SS, Hernandez E, Liu S, Kumar M, Guda PR, Srivastava R, Mohanty SK, Kacar S, Mahajan S, Wanczyk KE, Khanna S, Murphy MP, Gordillo GM, Roy S, Wan J, Sen CK, Singh K. Endothelial Phospholipase Cg2 improves outcomes of diabetic ischemic limb rescue following VEGF therapy. 2022. May 1: 71(5):1149-1165.
    2. Abouhashem AS, Singh K, Azzazy HME, Sen CK. Is Low Alveolar Type II Cell SOD3in the Lungs of Elderly Linked to the Observed Severity of COVID-19? Antioxid Redox Signal. 2020 Jul 10;33(2):59-65.
    3. Roy S, Patel D, Khanna S, Gordillo GM, Biswas S, Friedman A, Sen CK. Transcriptome-wide analysis of blood vessels laser captured from human skin and chronic wound-edge tissue. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14472-7.
    4. Kuhn DE, Roy S, Radtke J, Khanna S, Sen CK. Laser microdissection and capture of pure cardiomyocytes and fibroblasts from infarcted heart regions: perceived hyperoxia induces p21 in peri-infarct myocytes. Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1245-53.

     Active Grants 

    NIH/NIDDK: U01DK119099 (state PI for Diabetic Foot Consortium)

    NIH/NIDDK: R01 DK128845 (PI)

    NIH/NIDDK: R01 DK125835 (PI)

    NIH/NIDDK: 1R01DK114718 (PI)

    NIH/NINDS: R01 NS042617 (PI)

    NIH/NIAID: R01 AI138981 (subaward co-PI)

    DoD/USAMRAA: W81XWH2110097 (PI)

    DoD/USAMRAA: W81XWH2110459 (co-I)

    NSF: DMR-2117629 (co-I)

  • Professional Organizations
    American Association for Advancement of Science
    American College of Nutrition
    American College of Sports Medicine
    American Heart Association (AHA)
    American Physiology Society
    Indian Science Congress Association
    International Society for Pathophysiology
    Physiological Society of India
    Scandinavian Physiological Society
    Society for Free Radical Biology & Medicine, USA
    Wound Healing Society
  • Awards
    Org: National Academy of Inventors
    Desc: Fellow
    Scope: International
    Date: 1905-07-15
    Org: Indiana University
    Desc: Bicentennial Medal
    Scope: University
    Date: 1905-07-14
    Org: Indiana University
    Desc: Distinguished Professor
    Scope: University
    Date: 1905-07-14

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