Yen-Chun (Charly) Lai, PhD
Assistant Professor of Medicine
Assistant Professor of Medicine
Adjunct Assistant Professor of Cellular &
Integrative Physiology
Bio
Dr. Lai’s research has been focused primarily on investigating pathogenesis and development of alternative therapies for effective treatment of cardiopulmonary diseases, with the particular emphasis of metabolic syndrome, pulmonary hypertension, and heart failure with preserved ejection fraction (PH-HFpEF). She has made several important contributions to the field of pulmonary hypertension research, which include publishing research articles on 1) the effects and mechanisms of nitrite and metformin in a newly developed rat model of PH-HFpEF; 2) establishing mouse model of PH-HFpEF; 3) developing tools for rapid and accurate measurement of pulmonary vascular remodeling; and 4) identifying candidate genes associated with high-fat diet-induced pulmonary hypertension with a genome-wide association study.
Currently, much of her effort is focused on unraveling the role of sirtuin-3 (SIRT3) in skeletal muscle and its modulation of endocrine signaling pathways in PH-HFpEF. In a recent work related to an ongoing collaboration with investigators at University of Pittsburgh, she observed an interesting link between skeletal muscle SIRT3 deficiency and remote pulmonary vascular remodeling. This is largely an unexplored area which may provide new mechanistic understanding of PH-HFpEF and potentially answer some key questions related to the treatment of cardiopulmonary diseases, as well as aging. Together with a team of collaborators, she is currently seeking to explore the nature of molecular regulation with respect to skeletal muscle SIRT3 deficiency and remote pulmonary vascular remodeling with a particular focus on lysyl oxidase homolog 2 (LOXL2) and gremlin-1 (Grem1).
Additionally, Dr. Lai studies effect of Remodulin (with Dr. Mark Gladwin; University of Pittsburgh), effect of Rapamycin (with Dr. Elena Goncharova; University of Pittsburgh), exercise effects (with Dr. Tim Lahm; Indiana University School of Medicine), and the role of NAMPT (with Dr. Roberto Machado; Indiana University School of Medicine) in PH-HFpEF. As there are no effective therapies for PH-HFpEF treatment available at present, these studies will provide new insight into the development of more specific and effective treatments.
Key Publications
Lai, YC, Tabima DM, Dube JJ, Hughan KS, Goncharov DA, St Croix CM, Garcia-Ocaña A, Goncharova EA, Tofovic SP, Mora AL, Gladwin MT. SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction. Circulation 2016 Feb 23; 133(8): 717-31. PMCID: PMC4766041.
Meng Q, Lai YC, Kelly NJ, Bueno M, Baust JJ, Bachman TN, Goncharova D, Vanderpool RR, Radder JE, Hu J, Goncharova E, Morris AM, Mora AL, Shapiro SD, Gladwin MT. Development of a Mouse Model of Metabolic Syndrome, Pulmonary Hypertension and Heart Failure with Preserved Ejection Fraction. American Journal of Respiratory Cell and Molecular Biology 2017 Apr; 56(4):497-505. PMCID: PMC5449511.
Dmitry A. Goncharov, Elena A. Goncharova, Stevan P. Tofovic, Jian Hu, Jeff J. Baust, Andressa Z. Pena, Arnab Ray, Analise Rode, Rebecca R. Vanderpool, Ana L. Mora, Mark T. Gladwin, Yen-Chun Lai. (2018) Metformin Therapy for Pulmonary Hypertension associated with HFpEF versus PAH. American Journal of Respiratory Critical Care Medicine 2018 Sep 1; 198(5): 681-684. PMCID: PMC6118018.
Year | Degree | Institution |
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2012 | PhD | National Defense Medical Center |
2004 | MS | Taipei Medical College |
• Metabolic syndrome associated pulmonary hypertension with heart failure with preserved ejection fraction (PH-HFpEF) • Skeletal muscle SIRT3-modulated endocrine signaling pathway in PH-HFpEF •
Thomas HIS; Chen YS; Hung CH; Sreerangaraja Urs DB; Liao TL; Lai YC; Komrskova K; Postlerová P; Lin YF; Kao SH; Oxidative medicine and cellular longevity 2021 Sep 4
Satoh T; Wang L; Espinosa-Diez C; Wang B; Hahn SA; Noda K; Rochon ER; Dent MR; Levine AR; Baust JJ; Wyman S; Wu YL; Triantafyllou GA; Tang Y; Reynolds M; Shiva S; Hilaire CS; Gomez D; Goncharov DA; Goncharova EA; Chan SY; Straub AC; Lai YC; McTiernan CF; Gladwin MT; Circulation 2021 Jun 23
Culley MK; Zhao J; Tai YY; Tang Y; Perk D; Negi V; Yu Q; Woodcock CC; Handen A; Speyer G; Kim S; Lai YC; Satoh T; Watson AM; Aaraj YA; Sembrat J; Rojas M; Goncharov D; Goncharova EA; Khan OF; Anderson DG; Dahlman JE; Gurkar AU; Lafyatis R; Fayyaz AU; Redfield MM; Gladwin MT; Rabinovitch M; Gu M; Bertero T; Chan SY; The Journal of clinical investigation 2021 Jun 1
Martin B; Vanderpool RR; Henry BL; Palma JB; Gabris B; Lai YC; Hu J; Tofovic SP; Reddy RP; Mora AL; Gladwin MT; Romero G; Salama G; Frontiers in cardiovascular medicine 2021 Jul 6
Potus F; Frump AL; Umar S; R Vanderpool R; Al Ghouleh I; Lai YC; Pulmonary circulation 2021 Aug 19
Todd N; Lai YC; Frontiers in medicine 2020 Oct 7
Nickel NP; Yuan K; Dorfmuller P; Provencher S; Lai YC; Bonnet S; Austin ED; Koch CD; Morris A; Perros F; Montani D; Zamanian RT; de Jesus Perez VA; American journal of respiratory and critical care medicine 2020 Jan 15
Thapa D; Zhang M; Manning JR; Guimarães DA; Stoner MW; Lai YC; Shiva S; Scott I; Physiological reports 2019 Apr
Goncharov DA; Goncharova EA; Tofovic SP; Hu J; Baust JJ; Pena AZ; Ray A; Rode A; Vanderpool RR; Mora AL; Gladwin MT; Lai YC; American journal of respiratory and critical care medicine 2018 Sep 1
Hensley MK; Levine A; Gladwin MT; Lai YC; American journal of physiology. Lung cellular and molecular physiology 2018 Feb 1
Lai YC; Provencher S; Goncharova EA; Thorax 2018 Dec 15
Lai YC; Wang L; Gladwin MT; The Journal of physiology 2018 Dec 13
Meng Q; Lai YC; Kelly NJ; Bueno M; Baust JJ; Bachman TN; Goncharov D; Vanderpool RR; Radder JE; Hu J; Goncharova E; Morris AM; Mora AL; Shapiro SD; Gladwin MT; American journal of respiratory cell and molecular biology 2017 Apr
Kelly NJ; Radder JE; Baust JJ; Burton CL; Lai YC; Potoka KC; Agostini BA; Wood JP; Bachman TN; Vanderpool RR; Dandachi N; Leme AS; Gregory AD; Morris A; Mora AL; Gladwin MT; Shapiro SD; American journal of respiratory cell and molecular biology 2017 Apr
Kelly NJ; Dandachi N; Goncharov DA; Pena AZ; Radder JE; Gregory AD; Lai YC; Leme AS; Gladwin MT; Goncharova EA; St Croix CM; Shapiro SD; Current protocols in cytometry 2016 Oct 10
Lai YC; Tabima DM; Dube JJ; Hughan KS; Vanderpool RR; Goncharov DA; St Croix CM; Garcia-Ocaña A; Goncharova EA; Tofovic SP; Mora AL; Gladwin MT; Circulation 2016 Jan 26
Lai YC; Gladwin MT; Circulation 2016 Aug 9
Hu J; Xu Q; McTiernan C; Lai YC; Osei-Hwedieh D; Gladwin M; American journal of cardiovascular drugs : drugs, devices, and other interventions 2015 Aug
Lai YC; Potoka KC; Champion HC; Mora AL; Gladwin MT; Circulation research 2014 Jun 20
Zhu X; Ng HP; Lai YC; Craigo JK; Nagilla PS; Raghani P; Nagarajan S; Journal of immunology (Baltimore, Md. : 1950) 2014 Jul 18
Bueno M; Lai YC; Romero Y; Brands J; St Croix CM; Kamga C; Corey C; Herazo-Maya JD; Sembrat J; Lee JS; Duncan SR; Rojas M; Shiva S; Chu CT; Mora AL; The Journal of clinical investigation 2014 Dec 22
Sparacino-Watkins CE; Lai YC; Gladwin MT; Circulation 2012 May 9
Lai YC; Pan KT; Chang GF; Hsu CH; Khoo KH; Hung CH; Jiang YJ; Ho FM; Meng TC; Circulation research 2011 Oct 20
Chen CS; Wu CH; Lai YC; Lee WS; Chen HM; Chen RJ; Chen LC; Ho YS; Wang YJ; Toxicology 2008 Jan 19
Ho YS; Chen CH; Wang YJ; Pestell RG; Albanese C; Chen RJ; Chang MC; Jeng JH; Lin SY; Liang YC; Tseng H; Lee WS; Lin JK; Chu JS; Chen LC; Lee CH; Tso WL; Lai YC; Wu CH; Toxicology and applied pharmacology 2005 Jan 8
Smith JW 2nd; Longo DL; Alvord WG; Janik JE; Sharfman WH; Gause BL; Curti BD; Creekmore SP; Holmlund JT; Fenton RG; The New England journal of medicine 1993 Mar 18
Desc: 2018 Jenesis Innovative Research Award
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Desc: 2017 3CPR Junior Investigator Travel Award
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Desc: 2016 Gilead Sciences Pulmonary Arterial Hypertension Research Scholars Award
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Desc: 2015 Munich International Lung Conference Excellence in Science Research Award
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Desc: 2014 3CPR Cournand and Comroe Young Investigator Award (Finalist)
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Desc: 2014 Pittsburgh-Munich International Lung Conference Poster Award
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Desc: 2014 Nitric Oxide-Nitrite/Nitrate Conference 2014 Poster Prize Winner
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Desc: 2013 Scholarship to Munich International Autumn School for Lung Research
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Desc: 2013 Pittsburgh International Lung Conference Poster Award
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Desc: 2013 University of Pittsburgh School of Medicine Research Day Award
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Desc: 2011 Nitrite Pathophysiology and Therapy Travel Award
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Desc: 2010 American Society for Cell Biology Travel Award
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Desc: 2008 FAOBMB International Conference Poster Award
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