4256-Xu, Huiping

Huiping Xu, PhD

Associate Professor of Biostatistics & Health Data Science

Adjunct Associate Professor, School of Public Health

(317) 278-6735
HS 3000
Indianapolis, IN
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I am a biostatistician with research focus on the development of novel statistical methodologies in the biomedical sciences. I have extensive experience in applying statistical models to areas such as gastroenterology, health services research, diagnostic test evaluation, and medical informatics. My methodological research interests include latent variable models, longitudinal analysis, and survival analysis. 

Key Publications

Methodological Research

Li, X., Xu, H., Shen, C., Grannis, S.J. (2018). Automated linkage of patient records from disparate sources. Statistical Methods in Medical Research 27(1): 172-184.

Shen, C., Liu, Z., Xu, H., Liu, H., Yue, C. (2016). Control of false positives in randomized phase III clinical trials. Journal of biopharmaceutical statistics, 1-13.

Lai, D., Xu, H., Koller, D., Foroud, T., Gao, S. (2016). A multivariate finite mixture latent trajectory model with application to dementia studies. Journal of Applied Statistics 43(14): 2503-2523.

Hass, Z., Levine, M., Sands, L.P., Ting, J., Xu, H. (2016). The modeling of medical expenditure data from a longitudinal survey using the generalized method of moments (GMM) approach. Statistics in Medicine 35(15): 2652-2664.

Daggy, J., Xu, H., Hui, S.L., Grannis, S.J. (2014). Evaluating latent class models with conditional dependence in record linkage. Statistics in Medicine 33(24): 4250-4265.

Xu, H., Hui, S.L., Grannis, S.J. (2014). Optimal two-phase sampling design for comparing accuracies of two binary classification rules. Statistics in Medicine 33(3): 500-513.

Xu, H., Black, M., Craig, B.A. (2013). Evaluating Accuracy of Diagnostic Tests with Intermediate Results in the Absence of a Gold Standard. Statistics in Medicine 32(15): 2571-2584.

Daggy, J., Xu, H., Hui, S.L., Gamache, R.E., Grannis, S.J. (2013). A practical approach for incorporating dependence among fields in probabilistic record linkage. BMC Medical Informatics and Decision Making 13(1).

Xu, H., Daggy, J., Yu, D., Craig, B.A., Sands, L.P. (2013). Joint modeling of medical cost and survival in complex sample surveys. Statistics in Medicine 32(9): 1509-1523.

Xu, H. and Craig, B.A. (2010). Likelihood analysis of multivariate probit models using a parameter expanded MCEM algorithm. Technometrics 52: 340-348.

Xu, H. and Craig, B.A. (2009). A probit latent class model with general correlation structures for evaluating accuracy of diagnostic tests. Biometrics 65(4): 1145-1155.


Collaborative Research

Suarez, A.L., Xu, H., Cotton, P.B., Elmunzer, B.J., Adams, D., Morgan, K.A., Sheafor, D., Cote, G.A. Trends in the timing of inpatient ERCP relative to cholecystectomy: A nationwide database studied longitudinally. Gastrointesinal Endoscopy, April 2018. Epub ahead of print.

Imler, T.D., Sherman, S., Imperiale, T.F., Xu, H., Ouyang, F., Beesley, C., Hilton, C., Cote, G.A. (2018). Provider-specific quality measurement for ERCP using natural language processing. Gastrointestinal Endoscopy 87(1): 164-173.

James-Stevenson, T., Xu, H., Heit, M., Shin, A. (2018). Age and dyssynergia subtypes associated with normal sphincter pressures in women with fecal incontinence. Female Pelvic Medicine and Reconstructive Surgery 24(3): 247-251.

Pisoni, D., Broadstock, A., Wucinich, T., Safdar, N., Miller, K., Hernandez, L., Vasil, K., Boyce, L., Davies, A., Castelanos, I., Xu, H., Kronenberger, W., Moberly, A. (2018). Verbal learning and memory after cochlear implantation in postlingually deaf adults: Some new findings with CVLT-II. Ear and Hearing, December 2017. Epub ahead of print.

Watson, D., Ray, B., Robison, L., Xu, H., Edwards, R., Salyers, M., Hill, J., Shue, S. (2017). Developing substance use programming for person-oriented recovery and treatment (SUPPORT): Protocol for a pilot randomized controlled trial. Pilot and Feasibility Studies 3:73.

Fischer, M., Kao, D., Kassam, Z., Smith, J., Louie, T., Sipe, B., Torbeck, M., Xu, H., Ouyang, F., Mozaffarian, D., Allegretti, J. Stool donor body mass index does not affect recipient weight after a single fecal microbiota transplantation for C. difficile infection. Clinical Gastroenterology and Hepatology, December 2017. Epub ahead of print.

Kao, D., Roach, B., Silva, M., Beck. P., Rioux, K., Kaplan, G., Chang, H., Goodman, K., Xu, H., Madsen, K., Mason, A., Wong, G.K., Jovel, J., Patterson, J., Louie, T. (2017). Effect of oral capsule vs colonoscopy delivered fecal microbiota transplantation on recurrent clostridium difficile infection: A randomized clinical trial. Journal of the American Medical Association 318(20): 1985-1993.

Allegretti, J., Phelps, E., Allegretti, A., Xu, H., Fischer, M., Kassam, Z. (2017). Classifying fecal microbiota transplantation failure: An observational study examining timing and characteristics of FMT failures. Clinical Gastroenterology and Hepatology, November, 2017. Epub ahead of print.

Allegretti, J., Allegretti, A., Phelps, E., Xu, H., Kassam, Z., Fischer, M. (2017). Asymptomatic clostridium difficile carriage rate post-fecal microbiota transplant is low: A prospective clinical and stool assessment. Clinical Microbiology and Infection, November 2017. Epub ahead of print.

Edwards, J., Xu, H., Clark, D., Lin, G., Lesley, R., Unverzagt, F. (2017). Speed of processing training results in lower risk of dementia. Alzheimer’s and Dementia 3(4): 603-611.

Liu, C.J, Xu, H., Keith, N., Clark, D.O. (2017). Promoting ADL independence in vulnerable, community-dwelling older adults: a pilot RCT comparing 3-step Workout for Life versus resistance exercise. Clinical Interventions in Aging 12, 1141-1149.

Fischer, M., Sipe, B., Cheng, Y. W., Phelps, E., Rogers, N. A., Sagi, S. V., Bohm, M. E., Xu, H., Kassam, Z. (2017). Fecal microbiota transplant in severe and severe-complicated Clostridium difficile: A promising treatment approach. Gut microbes 8(3), 289-302.

Fischer, M., Phelps, E., Kao, D., Xu, H., Kelly, C. (2017). Response to Bodiwala and Skole. The American Journal of Gastroenterology 112(2): 391-392.

Cote, G.A., Xu, H., Easler, J.J., Imler, T.D., Teal, E., Sherman, S., Korc, M. (2017). Informative patterns of health care utilization prior to the diagnosis of pancreatic ductal adenocarcinoma. American Journal of Epidemiology 186(8): 944-951.

Kasthurirathne, S.N., Dixon, B.E., Gichoya, J., Xu, H., Xia, Y., Mamlin, B., Grannis, S.J. (2017). Towards better public health reporting using existing off the shelf approaches: The value of medical dictionaries in automated cancer detection using plaintext medical data. Journal of Biomedical Informatics 69, 160-176.

Hass, Z., DePalma, G., Xu, H., Craig, B., Sands, L.P. (2017). Unmet needs for help with activities of daily living disabilities and emergency department use among older Medicare recipients. The Genrontologist 57(2): 206-210.

Clark, D.O., Xu, H., Unverzagt, F.W. (2016). Does body mass index modify memory, reasoning, and speed of processing training effects in older adults? Obesity 24(11): 2319-2326.

Keith, N. R., Xu, H., de Groot, M., Hemmerlein, K., Clark, D.O. (2016). Identifying contextual and emotional factors to explore weight disparities between obese black and white women. Clinical Medicine Insights: Women's Health 9(S1): 85-93.

Fischer, M., Kao, D., Kelly, C., Kuchipudi, A., Jafri, S., Blumenkehl, M., Rex, D., Mellow, M., Kaur, N., Sokol, H., Cook, G., Hamilton, M.J., Phelps, E., Sipe, B., Xu, H., Allegretti, J. (2016). Fecal microbiota transplantation is safe and efficacious for recurrent or refractory Clostridium Difficile infection in patients with inflammatory bowel disease. Inflammatory Bowel Disease 22(10): 2402-2409.

Clark, D.O., Xu, H., Unverzagt, F.W., Hendrie, H. (2016). Does targeted cognitive training reduce educational disparities in cognitive function among cognitively normal older adults? International Journal of Geriatric Psychiatry 31(7): 809-817.

Fischer, M., Kao, D., Mehta, S.R., Martin, T., Dimitry, J., Keshteli, A.H., Cook, G.K., Phelps, E., Sipe, B.W., Xu, H., Kelly, C.R. (2016). Predictors of early failure after fecal microbiota transplantation for the therapy of Clostridium Difficile infection: A multicenter study. The American Journal of Gastroenterology 111(7): 1024-1031.

Clark, D.O., Unroe, K.T., Xu, H., Keith, N.R., Callahan, C.M., Tu, W. (2016). Sex and race differences in the relationship between obesity and C-reactive protein. Ethnicity and Disease 26(2): 197-204.

Kasthurirathne, S.N., Dixon, B.E., Gichoya, J., Xu, H., Xia, Y., Mamlin, B., Grannis, S.J. (2016). Towards Better Public Health Reporting Using Existing Off the Shelf Approaches: A Comparison of Alternative Cancer Detection Approaches Using Plaintext Medical Data and Non-dictionary Based Feature Selection. Journal of Biomedical Informatics 60: 145-152.

Cote, G.A., Silvka, A., Tarnasky, P., Mullady, D.K., Elmunzer, J., Elta, G., Fogel, E., Lehman, G., McHenry, L., Romagnuolo, J., Menon, S., Siddiqui, U.D., Watkins, J., Lynch, S., Denski, C., Xu, H., Sherman, S. (2016). Effect of covered metallic stents compared with plastic stents on benign biliary stricture resolution: A randomized clinical trial. Journal of the American Medical Association 315(12): 1250-1257.

Wu, J., Grannis, S.J., Xu, H., Finnell, J.T. (2016). A practical method for predicting frequent use of emergency department care using routinely available electronic registration data. BMC Emergency Medicine 16:12.

Cote, G.A., Lynch, S., Easler, J., Keen, A., Vassel, P., Sherman, S., Hui, S., Xu, H. (2015). Development and validation of a prediction model for unplanned admission following Endoscopic Retrograde Cholangiopancreatography. Clinical Gastroenterology and Hepatology 13(13): 2323-2332.

Cote, GA, Gore, A., McElyea, S., Heather, L., Xu, H., Sherman, S., Korc, M. (2015). Response to Le Large et al. The American Journal of Gastroenterology 110(5): 769-770.

He, S., Craig, B., Xu, H., Covinsky, K., Stallard, E., Thomas III, J., Hass, Z., Sands, L. (2015). Unmet need for ADL assistance is associated with mortality among older adults with mild disability. Journal of Gerontology Series A: Biological Sciences and Medical Sciences 70(9): 1128-1132.

Imler, T.D., Ring, N., Johnson, C.S., Xu, H., Beesley, C., Hilton, C., Duke, J., Imperiale, T. (2015). Multi-center Colonoscopy Quality Measurement Utilizing Natural Language Processing. The American Journal of Gastroenterology 110(4): 543-552.

Kondaurova, M.V., Bergeson, T.R., Xu, H., Kitamura, C. (2015). Affective properties of mothers’ speech to hearing-impaired infants with cochlear implants. Journal of Speech, Language and Hearing Research 58: 590-600.

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