Yao-Ying Ma, MD, PhD
Associate Professor of Pharmacology & Toxicology
- ym9@iu.edu
- Phone
- 317-274-1536
- Address
-
VanNuys Medical Science Building MS-Room 350
635 Barnhill Drive
Indianapolis, IN 46202
Bio
Dr. Yao-Ying Ma, a M.D. & Ph.D., has been investigating the neurobiology mechanisms underlying substance abuse for 20 years and has successfully extended her expertise into neurodegenerative diseases research since she became an independent PI. After earning her Ph.D. of Neurobiology in 2006, Dr. Ma first started a research fellow position in the Department of Psychiatry, McLean Hospital, Harvard Medical School. From 2008 to 2011, she went on to work as a postdoctoral researcher with Drs. Christopher Evans and Michael Levin in the Department of Psychiatry and Biobehavioral Sciences at UCLA. After that, she continued her research training in addiction neurobiology as a postdoctoral associate with Dr. Yan Dong in the Department of Neuroscience, University of Pittsburgh.
In 2015, Dr. Ma was appointed as a Tenure-track Assistant Professor in the Behavioral Neuroscience Program, Department of Psychology, Binghamton University-SUNY. She joined the faculty of Department of Pharmacology and Toxicology at Indiana University School of Medicine and IU Stark Neurosciences Research Institute in July of 2018.
Key Publications
Huang D, Ma YY. Increased Excitability of Layer 2 Cortical Pyramidal Neurons in the Supplementary Motor Cortex Underlies High Cocaine Seeking Behaviors. Biological Psychiatry, 2023 Jun. PMID: 37330163
Guo C, Wen D, Zhang Y, Mustaklem R, Mustaklem B, Zhou M, Ma T, Ma YY. Amyloid-β oligomers in the nucleus accumbens decrease motivation via insertion of calcium-permeable AMPA receptors. Molecular Psychiatry. 2022 Feb 2. 27(4); 2146-2157. PMID: 35105968
Roselli V, Guo C, Huang D, Wen D, Zona D, Liang T, Ma YY. Prenatal alcohol exposure reduces posterior dorsomedial striatum excitability and motivation in a sex- and age-dependent fashion. Neuropharmacology. 2020 Dec 1; 180:108310. ; PMID: 32950559
Shan L, Galaj E, Ma YY. Nucleus accumbens shell small conductance potassium channels underlie adolescent ethanol exposure-induced anxiety. Neuropsychopharmacology. 2019 Oct; 44 (11):1886-1895. PMID: 31096263
Ma YY, Wang X, Huang Y, Marie H, Nestler EJ, Schlüter OM, Dong Y. Re-silencing of silent synapses unmasks anti-relapse effects of environmental enrichment. Proc Natl Acad Sci U S A. 2016 May 3;113(18):5089-94. PMID: 27091967
Ma YY, Lee BR, Wang X, Guo C, Liu L, Cui R, Lan Y, Balcita-Pedicino JJ, Wolf ME, Sesack SR, Shaham Y, Schlüter OM, Huang YH, Dong Y. Bidirectional modulation of incubation of cocaine craving by silent synapse-based remodeling of prefrontal cortex to accumbens projections. Neuron. 2014 Sep 17;83(6):1453-67. PMID: 25199705
Lee BR, Ma YY (Co-first Author), Huang YH, Wang X, Otaka M, Ishikawa M, Neumann PA, Graziane NM, Brown TE, Suska A, Guo C, Lobo MK, Sesack SR, Wolf ME, Nestler EJ, Shaham Y, Schlüter OM, Dong Y. Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving. Nat Neurosci. 2013 Nov;16 (11):1644-51. PMID: 24077564
| Year | Degree | Institution |
|---|---|---|
| 2006 | PhD | Peking University |
| 2001 | MD | Shanxi Medical University |
Dr. Ma's research goals are to explore the synaptic and cellular plasticity in the striatum in mental and neurological disorders, including substance abuse and neurodegenerative diseases, and to rescue or delay the pathological neuroadaptations. This will pave the way not only for understanding the neurobiology mechanism underlying these disorders, but also for providing precise neural targets for preventing and treating them.
Ongoing Project 1: Synaptic adaptations and behavioral changes induced by prenatal alcohol exposure and adolescent alcohol exposure.
Ongoing Project 2: Neural synatpic and circuitry plasticity underlying cocaine and opiate addiction.
Ongoing Project 3: Role of nucleus accumbens and calcium-permeable AMPA receptors in the pathophysiology of Alzheimer's and Huntington's diseases.
Guo C; Wen D; Zhang Y; Mustaklem R; Mustaklem B; Zhou M; Ma T; Ma YY; Molecular psychiatry 2022 Feb 2
Guo C; Ma YY; Frontiers in neural circuits 2021 Aug 17
Galaj E; Guo C; Huang D; Ranaldi R; Ma YY; Drug and alcohol dependence 2020 Sep 21
Roselli V; Guo C; Huang D; Wen D; Zona D; Liang T; Ma YY; Neuropharmacology 2020 Sep 17
Luo YX; Huang D; Guo C; Ma YY; CNS neuroscience & therapeutics 2020 Oct 29
Luo YX; Galaj E; Ma YY; Journal of neuroscience research 2020 Oct 22
Shan L; Galaj E; Ma YY; Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2019 May 16
Ma YY; Pharmacological research 2019 Feb 23
Ma YY; Wang X; Huang Y; Marie H; Nestler EJ; Schlüter OM; Dong Y; Proceedings of the National Academy of Sciences of the United States of America 2016 Apr 18
Ma YY; Lee BR; Wang X; Guo C; Liu L; Cui R; Lan Y; Balcita-Pedicino JJ; Wolf ME; Sesack SR; Shaham Y; Schlüter OM; Huang YH; Dong Y; Neuron 2014 Sep 4
Lee BR; Ma YY; Huang YH; Wang X; Otaka M; Ishikawa M; Neumann PA; Graziane NM; Brown TE; Suska A; Guo C; Lobo MK; Sesack SR; Wolf ME; Nestler EJ; Shaham Y; Schlüter OM; Dong Y; Nature neuroscience 2013 Sep 29
Ma YY; Henley SM; Toll J; Jentsch JD; Evans CJ; Levine MS; Cepeda C; ASN neuro 2013 Oct 2
Chen B; Ma YY; Wang Y; Wang X; Schlüter OM; Dong Y; Huang YH; Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2013 May 15
Ma YY; Cepeda C; Chatta P; Franklin L; Evans CJ; Levine MS; ASN neuro 2012 Mar 8
Ma YY; Meng L; Guo CY; Han JS; Lee DY; Cui CL; Behavioural brain research 2009 Jun 17
Ma YY; Cepeda C; Cui CL; International review of neurobiology 2009
Ma YY; Chu NN; Guo CY; Han JS; Cui CL; Experimental neurology 2006 Oct 2
Ma YY; Guo CY; Yu P; Lee DY; Han JS; Cui CL; Experimental neurology 2006 Apr 24
Desc: Integrative Artificial Intelligence (iAI) Seed Award
Scope: University
Date: 2022-02-01
Desc: NIH Research Grant (R01) Award
Scope: National
Date: 2021-09-01
Desc: Indiana State Traumatic Brain and Spinal Cord Injury Award
Scope: State
Date: 2020-09-01
Desc: NIH Research Grant (R21) Award
Scope: National
Date: 2018-09-30
Desc: NIH Research Grant (R01) Award
Scope: National
Date: 2017-07-20
Desc: ACNP Travel Award
Scope: National
Date:
Desc: Dean's Research Semester Award
Scope: School
Date:
Desc: NARSAD Young Investigator Award 2016
Scope: National
Date:
Desc: Binghamton University Career Champion 2016
Scope: University
Date: