41950-Willis, Monte

Monte S. Willis, MD, PhD

Professor of Pathology & Laboratory Medicine

635 Barnhill Drive
Van Nuys Medical Sciences Building 5067F

Indianapolis, IN 46202

Key Publications

In press

1. Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16. PLOS Genetics, in press.

2. Muscle-specific regulation of right ventricular transcriptional responses to chronic hypoxia-induced hypertrophy by the Muscle Ring Finger-1 (MuRF1)  ubiquitin ligase in vivo. BMC Med Genetics, in press.

3. Image-based methods for phase estimation, gating and temporal super-resolution of cardiac ultrasound. IEEE Trans Biomed Eng, in press.

Recently published

1.Adverse Effects of Fenofibrate in Mice Deficient in the Protein Quality Control Regulator, CHIP. J. Cardiovasc. Dev. Dis. 2018, 5(3), 43.

2. The Role of Heat Shock Proteins and Co-Chaperones in Heart Failure. Philos Trans R Soc Lond B Biol Sci. 2018;373(1738).

3. Leading Mindfully and Managing Compassionately: Strategies for Meeting Today’s Challenges in Pathology Academic Medicine. International Journal of Academic Medicine. 2018 4(1): 12-20.

4. Early Stages of the Cardiac Fuel Switch: Modeling the Transition from Physiological to Pathological Hypertrophy. J Am Heart Assoc. 2018;7(8).

5. Cardiovascular Health in African Americans: A Scientific Statement from the American Heart Association (endorsed by the American College of Cardiology). Circulation. 2017;136(21):e393-e423.


Titles & Appointments

  • Professor of Pathology & Laboratory Medicine
  • Professor of Medicine
  • Deputy Director, Indiana University Center for Musculoskeletal Health
  • Vice-Chair of Research, Department of Pathology &amp
  • Laboratory Medicine
  • Adjunct Professor, Krannert Cardiology Institute
  • Education
    2014 MBA University of North Carolina
    2001 PhD University of Nebraska
    2001 MD University of Nebraska
    1992 BS University of Nebraska-Lincoln
  • Research
    Our laboratory investigates the role of protein quality control in the pathogenesis of heart failure and myofibrillar myopathies, with three major themes:
    • Identifying the role of muscle-specific ubiquitin ligases (MuRF proteins) in regulating cell signaling and metabolism by regulating nuclear receptors
    • Determining how muscle-specific ubiquitin ligases degrade inherited mutant muscle proteins (e.g., cMyBP-C and BAG3 proteins) in the pathogenesis of heart failure
    • Discovery of mechanisms and therapies for Bag3 P209L myofibrillar myopathy (MFM).


    Research Program Links:

    Willis Laboratory Webpage / Personnel

    Google Scholar




    Indiana Center for Musculoskeletal Health

    The Indiana Center for Musculoskeletal Health harnesses the exceptional scientific talent already in place, in conjunction with new recruited talent, toward the discovery and development of new treatments, cures, preventative strategies, diagnostic tools, and technologies to address the increasing burden of bone, muscle and cartilage disorders among patients of all ages. The center aspires to be an international leader in basic and translational musculoskeletal disease research, clinical research, trials and treatment, and in musculoskeletal education.


    Indiana University Department of Pathology & Laboratory Medicine Research


  • Professional Organizations
    American Heart Association (Fellow, Council on Basic CV Sciences)
    American Physiological Society, Cardiovascular Section, Endocrinology & Metabolism Section
    American Society for Investigative Pathology (ASIP) (Council Member)
    American Society of Clinical Pathology (Fellow)
    Association for European Cardiovascular Pathology
    Association of Pathology Chairs (APC)
    College of American Pathologists (Fellow)
    International Society for Heart Research (North American Section Council Member)
    Society for Cardiovascular Pathology (Previous Council Member)
    United States & Canadian Academy of Pathology
  • Board Certifications
    American Board of Pathology - Pathology
  • Clinical Interests

    Metabolomics, metabolism, and biomarker discovery

    Alzheimer's Disease as a metastatic misfolded protein disease - Investigating cardiac and musculoskeletal involvement in human research studies

    Lean Six Sigma Methodology in the Clinical Laboratory (Yellow, Blue, Purple belt, Sponsor Experience)


  • Awards
    Org: American Society of Investigative Pathologists
    Desc: Cotran Early Career Investigator Award
    Scope: National
    Org: Jefferson-Pilot
    Desc: Jefferson-Pilot Fellowship in Academic Medicine
    Scope: State

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