Dr. Xiumei Huang is a tenure-track Assistant Professor in the Department of Radiation Oncology and full member of Indiana University Simon Comprehensive Cancer Center. Prior to her appointment at Indiana University, she received her Ph.D. training in neuroscience from Sanford Burnham Prebys Medical Discovery Institute (La Jolla, CA). Dr. Huang received her postdoctoral training in chemotherapy, radiotherapy and immunotherapy for cancer at UT Southwestern Medical Center/Simmons Comprehensive Cancer Center (Dallas, TX).
Overall, Dr. Huang lab has three broad areas of research ongoing. The first area focuses on understanding the mechanism of tumor-selective, radiosensitization of Non-Small Cell Lung Cancer (NSCLC), Triple Negative Breast Cancer (TNBC) or Pancreatic Ductal Adenocarcinoma (PDA) using a novel NQO1 bioactivatable drug. The second area focuses on screening novel NQO1 bioactivatable drugs and uncovering the mechanisms underlying the synergy between these drugs and PARP inhibitors. The third area focuses on investigating the mechanism by which NQO1 bioactivatable drugs stimulate innate and adaptive immunity.
Current Research Funding
NIH R01CA240952-01 (Huang, PI), Targeting NQO1+ tumor to trigger innate and adaptive immunity.
NIH 1R01CA224493-02 (Huang, PI), Tumor-selective radiosensitization of NSCLC using NQO1 bioactivatable drugs.
NIH 5R01CA221158-03 (Huang & Motea, MPI), Tumor-selective use of PARP inhibitors against NQO1+ non-small cell lung cancer.
Current Lab Members Related Link: Huang Lab
Postdoctoral fellow: Ph.D. student:
Lingxiang Jiang, Ph.D. Ye Zhao
Xiaolin Su, Ph.D. Hao Zhou
Jiangwei Wang, Ph.D. Colton L. Starcher