Bio
Dr. Hao is a physician-scientist who has been practicing clinical neuropathology and conducting laboratory research in the last 25 years. His research has been funded by National Institutes of Health (NIH), National Cancer Institute (NCI), Canadian Institutes of Health Research (CIHR), and other agencies. His research is focusing on protein ubiquitination and degradation and targeted anticancer and antiaging drug discovery. He has served several NCI study sections.
Dr. Hao received MD, MSc in pathology, PhD in cellular biology/Anatomy and neuropathology residency training. He is a certified neuropathologist and Fellow of Royal College of Physicians of Canada (FRCPC). He started his academic career at University of Alberta and then moved to Emory University and McGill University. In January 2018, he joined the Indiana University School of Medicine as the Bicentennial Chair, Professor of Pathology and Laboratory Medicine and Adjunct Professor of Neurological Surgery. He also serves a neuropathologist at Indiana University Health.
Key Publications
Bellail AC, Jin HR, Lo HY, Jung SH, Hamdouchi C, Kim D, Higgins RK, Blanck M, le Sage C, Cross BCS, Li J, Mosley AL, Wijeratne AB, Jiang W, Ghosh M, Zhao YQ, Hauck PM, Shekhar A, Hao C. Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors. Sci Transl Med. 2021 Oct 13;13(615):eabh1486. doi: 10.1126/ scitranslmed.abh1486. Epub 2021 Oct 13.PMID: 34644148.
Mirzaei R, Gordon A, Zemp FJ, Kumar M, Sarkar S, Luchman HA, Bellail AC, Hao C, Mahoney DJ, Dunn JF, Bose P, Yong VW. PD-1 independent of PD-L1 ligation promotes glioblastoma growth through the NFκB pathway. PD-1 inde. Sci Adv. 2021 Nov 5;7(45):eabh2148. doi: 10.1126/sciadv. abh2148. Epub 2021 Nov 5. PMID: 34739319 Free PMC article.
Bellail ACj, Olson JJ, Hao Cj. SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression. Nat Commun 2014 June 23; 5:4234. PMID: 24953629
Bellail AC, Olson J, Yang X, Chen Z, Hao Cj. A20 ubiquitin ligase-mediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastoma. Cancer Discov 2012 Feb; 2(2):140-155. Epub 2012 Jan 24. PMID: 22585859
Titles & Appointments
- Bicentennial Professor of Pathology & Laboratory Medicine
- Professor of Neurological Surgery
- Bicentennial Chair, Pathology and Laboratory Medicine
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Education
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Research
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Professional Organizations
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Clinical Interests
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Awards