Vijay Saxena, MBA, PhD, MSC

Bio

Dr. Vijay Saxena is a Research Assistant Professor of Pediatrics at Indiana University School of Medicine. He completed his PhD work at King George’s Medical College, Lucknow, India in the Dept. of Micobiology, followed by Post-Doctoral Fellowship at University of Cincinnati and Cincinnati Children’s Research Foundation, Cincinnati, USA. He then joined Nationwide Children’s Research Institute, Columbus, Ohio as Research Scientist in Prof. Andrew Schwaderer laboratory. His current research focus is on renal innate immune response to uropathogens.

Key Publications

Saxena V, Hains DS, Ketz J, Chanley M, Spencer JD, Becknell B, Pierce KR, Nelson RD, Purkerson JM, Schwartz GJ, Schwaderer AL. 2017. Cell specific qRT-PCR of renal epithelial cells reveals a novel innate immune signature in murine collecting duct. Article in Press. Am J Physiol Renal Physiol (May 3, 2017). doi:10.1152/ajprenal.00512.2016

Kusumi K, Barr-Beare E, Saxena V, Safedi F, Schwaderer AL. 2017. Renal Calcium Oxalate deposits induce a pro-atherosclerotic and Pro-Osteoporotic response in mice. J. Cell Biochem, doi:10.1002/jcb.25924

Kusumi, K, Barr-Beare E, Saxena, V, Schober MS, Clingenpeel MM, Schwaderer A.L. 2015. Pediatric Origins of Nephrolithiasis Associated Atherosclerosis. J. Pediatr. Sep 10. pii: S0022-3476(15)00870-7. doi: 10.1016/j.jpeds.2015.08.014.

Barr-Beare, E*, Saxena, V*, Hilt, EE, White, CT, Schober M, Li B, Becknell, B, Hains DS, Wolfe AJ, Schwaderer, AL. 2015. The Interaction between enterobacteriaceae and calcium oxalate deposits. PLoS ONE 10(10): e0139575. doi:10.1371/journal.pone.0139575 9 (*co-first author)

Hains DS, Chen X, Saxena V, Barr-Beare E, Flemming W, Easterling R, Becknell B, Schwartz GJ, Schwaderer AL. 2014. Carbonic anhydrase 2 deficiency leads to increased pyelonephritis susceptibility. Am J Physiol Renal Physiol,1;307(7):F869-80

Schwaderer, AL, Wang, H, Kim SH, Kline JM, Liang D, Brophy PD, Mchugh KM, Tseng GC, Saxena, V, Barr-Beare, E, Pierce KR, Shaikh N, Manak RJ, Cohen DM, Spencer JD, Baker PB, Yu CY, Hains DS. 2016. Polymorphisms in α-Defensin-Encoding DEFA1A3 associate with Urinary tract infection risk in children with Vesicoureteral reflux. J. Am. Soc. Nephrol. 27(10):3175-3186.Epub 2106 Mar 3.

Caterino JM, Hains DS, Camargo CA, Quraishi SA, Saxena V, Schwaderer AL. 2015. A prospective, observational pilot study for use of urinary antimicrobial peptides in diagnosing emergency department patients with positive urine culture. Acad Emerg Med. Oct;22(10):1226-30. doi: 10.1111/acem.12770. Epub 2015 Sep 16.

Saxena, V, Shivakumar, P, Sabla, G, Bezerra, JA. 2011. Dendritic cell regulate natural killer cell activation and epithelial injury in experimental biliary atresia. Science Translational Medicine 3, 102ra94

Meithke, A, Saxena, V, Shivakumar, P, Bezerra, JA. 2010. Paucity of regulatory T cells and lack of control of NK cell activation in experimental biliary atresia. Journal of Hepatology, 52: 718-726.

Kohli, R, Kirby, M, Xanthakos, SA, Saxena, V, Tang, PH, Miles, L, Miles, MV, Balistreri, WF, Woods, SC, Seeley, RJ. 2010. High- Fructose-Diet Induces Hepatic Fibrosis and Elevates Plasma Oxidized Coenzyme Q9 in a Novel Murine Model of Obesity and NASH. Hepatology. 52: 932-944.

Saxena, V, Lienesch, DW, Zhou, M, Bommireddi, R, Azhar, M, Doetschman, T, Singh, RR. 2008. Dual role of immunoregulatory cytokine TGFβ in the pathogenesis of autoimmune mediated organ damage. J. Immunol. 180: 1903-1912.

Saxena, V, Ondr, JK, Magnusen, AF, Katz, JD. 2007. The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes. J. Immunol. 179: 5041-5053.

Albuquerque, DA, Saxena V, Adams, DA, Boivin, GP, Brunner, H, Witte, DP, Singh, RR. 2004. An angiotensin converting enzyme inhibitor reduces systemic type 2 cytokine production and renal TGFβ expression: Implications for the treatment of chronic progressive lupus nephritis. Kidney International. 65:846-859.

Saxena, V, Yang, JQ, Chun, T, Xu, H, Wang, CR, Kaer, LV, Singh, RR. 2003. Repeated α-galactosylceramide administration results in expansion of NKT cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice. J. Immunol, 171:4439-4436.

Saxena, V, Singh, RR, Zhang, S, Li, L, Finkelman, FD, Witte, DP, Jacob, CO. 2003. Differential contribution of IL-4 and STAT6 versus STAT4 to the development of kidney disease in the NZM.2410 mice. J. Immunol, 170:4818-4825.

Titles & Appointments

Assistant Research Professor of Pediatrics

Education

2009 MBA University of Phoenix

1999 PhD Kanpur University

1993 MSC Kanpur University

1990 BSC Kanpur University
Research

Dr Saxena's research interest evolve around understanding the innate immune response to uropathogen and autoimmue diseases. Renal collecting duct of the kidney is uniquely positioned to respond to ascending uroptahogen. In collaboration with Prof. Andrew Schwaderer laboratory he generated two novel transgenic reporter mice to fluorescently label collecting duct, Intercalated (IC) and Principal cells (PC) comprising ~1-2% of the whole kidney cells. This allows the specific enrichment of these two cells to study their immune response to pathogen. In his preliminary work, he found novel innate immune gene expression in these cells. Overall goal of his research is to understand the mechanism of how renal cells maintain urinary tract sterlity to develop novel therapeutics for the treatment of urianry tract infections.
Clinical Interests

N/A

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