38988-Saxena, Vijay
Faculty

Vijay Saxena, PhD, MBA, MSC

Assistant Research Professor of Pediatrics

Address
RR 230
PNEF
IN
Indianapolis, IN

Bio

Dr. Vijay Saxena is a Research Assistant Professor of Pediatrics at Indiana University School of Medicine. He completed his PhD work at King George’s Medical College, Lucknow, India in the Dept. of Micobiology, followed by Post-Doctoral Fellowship at University of Cincinnati and Cincinnati Children’s Research Foundation, Cincinnati, USA. He then joined Nationwide Children’s Research Institute, Columbus, Ohio as Research Scientist in Prof. Andrew Schwaderer laboratory. His current research focus is on renal innate immune response to uropathogens.

 

Key Publications

Saxena V, Hains DS, Ketz J, Chanley M, Spencer JD, Becknell B, Pierce KR, Nelson RD, Purkerson JM, Schwartz GJ, Schwaderer AL. 2017. Cell specific qRT-PCR of renal epithelial cells reveals a novel innate immune signature in murine collecting duct. Article in Press. Am J Physiol Renal Physiol (May 3, 2017). doi:10.1152/ajprenal.00512.2016

 

Kusumi K, Barr-Beare E, Saxena V, Safedi F, Schwaderer AL. 2017. Renal Calcium Oxalate deposits induce a pro-atherosclerotic and Pro-Osteoporotic response in mice. J. Cell Biochem, doi:10.1002/jcb.25924

 

Kusumi, K, Barr-Beare E, Saxena, V, Schober MS, Clingenpeel MM, Schwaderer A.L. 2015. Pediatric Origins of Nephrolithiasis Associated Atherosclerosis. J. Pediatr. Sep 10. pii: S0022-3476(15)00870-7. doi: 10.1016/j.jpeds.2015.08.014.

 

Barr-Beare, E*, Saxena, V*, Hilt, EE, White, CT, Schober M, Li B, Becknell, B, Hains  DS, Wolfe  AJ, Schwaderer, AL. 2015. The Interaction between enterobacteriaceae  and calcium oxalate deposits. PLoS ONE 10(10): e0139575. doi:10.1371/journal.pone.0139575 9 (*co-first author)

 

Hains DS, Chen X, Saxena V, Barr-Beare E, Flemming W, Easterling R, Becknell B, Schwartz GJ, Schwaderer AL. 2014. Carbonic anhydrase 2 deficiency leads to increased pyelonephritis susceptibility. Am J Physiol Renal Physiol,1;307(7):F869-80

 Schwaderer, AL, Wang, H, Kim SH, Kline JM, Liang D, Brophy PD,   Mchugh KM, Tseng GC, Saxena, V, Barr-Beare, E, Pierce KR,   Shaikh N, Manak RJ, Cohen DM, Spencer JD, Baker PB, Yu CY,   Hains DS. 2016. Polymorphisms in α-Defensin-Encoding DEFA1A3   associate with Urinary tract infection risk in children with   Vesicoureteral reflux. J. Am. Soc. Nephrol. 27(10):3175-3186.Epub   2106 Mar 3.

 Caterino JM, Hains DS, Camargo CA, Quraishi SA, Saxena V,   Schwaderer AL. 2015. A  prospective, observational pilot study for   use of urinary antimicrobial peptides in diagnosing emergency   department patients with positive urine culture. Acad Emerg Med.   Oct;22(10):1226-30. doi: 10.1111/acem.12770. Epub 2015 Sep 16.

 Saxena, V, Shivakumar, P, Sabla, G, Bezerra, JA. 2011. Dendritic   cell regulate natural killer cell activation and epithelial injury in   experimental biliary atresia. Science Translational Medicine 3,   102ra94

 Meithke, A, Saxena, V, Shivakumar, P, Bezerra, JA. 2010. Paucity   of regulatory T cells and lack of control of NK cell activation in   experimental biliary atresia. Journal of Hepatology, 52: 718-726.

 Kohli, R, Kirby, M, Xanthakos, SA, Saxena, V, Tang, PH, Miles, L,   Miles, MV, Balistreri, WF, Woods, SC, Seeley, RJ. 2010. High-   Fructose-Diet Induces Hepatic Fibrosis and Elevates Plasma   Oxidized Coenzyme Q9 in a Novel Murine Model of Obesity and   NASH. Hepatology. 52: 932-944.

 Saxena, V, Lienesch, DW, Zhou, M, Bommireddi, R, Azhar, M,   Doetschman, T, Singh, RR. 2008. Dual role of immunoregulatory   cytokine TGFβ in the pathogenesis of autoimmune mediated organ   damage. J. Immunol. 180: 1903-1912. 

Saxena, V, Ondr, JK, Magnusen, AF, Katz, JD. 2007. The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes. J. Immunol. 179: 5041-5053. 

 Albuquerque, DA, Saxena V, Adams, DA, Boivin, GP, Brunner, H,   Witte, DP, Singh, RR. 2004. An angiotensin converting enzyme   inhibitor reduces systemic type 2 cytokine production and renal   TGFβ expression: Implications for the treatment of chronic   progressive lupus nephritis. Kidney International. 65:846-859.

 Saxena, V, Yang, JQ, Chun, T, Xu, H, Wang, CR, Kaer, LV, Singh,   RR. 2003. Repeated α-galactosylceramide administration results in   expansion of NKT cells and alleviates inflammatory dermatitis in   MRL-lpr/lpr mice. J. Immunol, 171:4439-4436

 Saxena, V, Singh, RR, Zhang, S, Li, L, Finkelman, FD, Witte, DP,   Jacob, CO. 2003. Differential contribution of IL-4 and STAT6 versus   STAT4 to the development of kidney disease in the NZM.2410   mice. J. Immunol, 170:4818-4825. 

Titles & Appointments

  • Assistant Research Professor of Pediatrics
  • Education
    2009 MBA University of Phoenix
    1999 PhD Kanpur University
    1993 MSC Kanpur University
    1990 BSC Kanpur University
  • Research

    Dr Saxena's research interest evolve around understanding the innate immune response to uropathogen and autoimmue diseases. Renal collecting duct of the kidney is uniquely positioned to respond to ascending uroptahogen. In collaboration with Prof. Andrew Schwaderer laboratory he generated two novel transgenic reporter mice to fluorescently label collecting duct, Intercalated (IC) and Principal cells (PC)  comprising ~1-2% of the whole kidney cells. This allows the specific enrichment of these two cells to study their immune response to pathogen. In his preliminary work, he found novel innate immune gene expression in these cells. Overall goal of his research is to understand the mechanism of how renal cells maintain urinary tract sterlity to develop novel therapeutics for the treatment of urianry tract infections. 

  • Clinical Interests

    N/A

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