
Roberto F. Machado, MD
Dr. Calvin H. English Professor
Bio
Dr. Machado received his MD from the Universidade Federal do Rio Grande do Sul, Brazil. He completed residency and chief residency in internal medicine at the University of Miami, pulmonary and critical care medicine fellowship at the Cleveland Clinic Foundation and post-doctoral research training at the National Heart Lung and Blood Institute.
Dr. Machado's laboratory focuses on the study of pulmonary hypertension and pulmonary complications of sickle cell disease. His research has contributed to the discovery of pulmonary hypertension as a major risk factor for death in adult patients with sickle cell disease. Using human oligonucleotide microarray platforms, genetics and bioinformatics tools, he currently seeks to develop novel diagnostic, prognostic and therapeutic biomarkers for patients with complex disorders such as pulmonary hypertension. His efforts have led to the identification of novel genetic modifiers and biochemical and molecular biomarkers in sickle cell disease and pulmonary hypertension. His laboratory also utilizes animal models of sickle cell disease and pulmonary hypertension to investigate the role of the pulmonary vascular endothelium in regulating vasomotor tone, permeability, vascular proliferation and apoptosis. By combining these approaches, Dr. Machado seeks to gain novel insights into the pathogenesis and treatment of these complex lung disorders, which would hopefully lead to an improvement in the morbidity and mortality associated with sickle cell disease and pulmonary hypertension.
Dr. Machado’s clinical interests include pulmonary hypertension and pulmonary complications of sickle cell disease.
Titles & Appointments
- Dr. Calvin H. English Professor
- Professor of Medicine
- Chief, Division of Pulmonary, Critical Care, Sleep, &
- Occupational Medicine
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Education2004 FEL Clinical Research Fellowship, Laboratory of Chemical Biology, National Institutes of Digestive Diabetes & Kidney Diseases, National Institutes of Health, Bethesda, MD2003 FEL Fellowship, Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, OH2000 RES Chief Medical Residency, Jackson Memorial Hospital/ VA Medical Center, University of Miami, Miami, FL1999 RES Residency, Jackson Memorial Hospital/ VA Medical Center, University of Miami, Miami, FL1993 MD Federal University of Rio Grande do Sul
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Research
Genetics, genomics and vascular biology of pulmonary hypertension and sickle cell disease
Precision Health
Lung health disparities
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PublicationsProgressive glomerular and tubular damage in sickle cell trait and sickle cell anemia mouse models.
Saraf SL; Sysol JR; Susma A; Setty S; Zhang X; Gudehithlu KP; Arruda JAL; Singh AK; Machado RF; Gordeuk VR; Translational research : the journal of laboratory and clinical medicine 2018 Feb 2Hemin Causes Lung Microvascular Endothelial Barrier Dysfunction by Necroptotic Cell Death.
Singla S; Sysol JR; Dille B; Jones N; Chen J; Machado RF; American journal of respiratory cell and molecular biology 2017 SepMicroRNA-1 Is Decreased by Hypoxia and Contributes to the Development of Pulmonary Vascular Remodeling via Regulation of Sphingosine Kinase 1.
Sysol JR; Chen J; Singla S; Zhao S; Comhair SAA; Natarajan V; Machado RF; American journal of physiology. Lung cellular and molecular physiology 2017 Nov 22Aberrant caveolin-1-mediated Smad signaling and proliferation identified by analysis of adenine 474 deletion mutation (c.474delA) in patient fibroblasts: a new perspective on the mechanism of pulmonary hypertension.
Marsboom G; Chen Z; Yuan Y; Zhang Y; Tiruppathi C; Loyd JE; Austin ED; Machado RF; Minshall RD; Rehman J; Malik AB; Molecular biology of the cell 2017 May 1Aberrant Caveolin-1-Mediated Smad Signaling and Proliferation Identified by Analysis of Adenine 474 Deletion Mutation (c.474delA) in Patient Fibroblasts: A New Perspective in the Mechanism of Pulmonary Hypertension.
Marsboom G; Chen Z; Yuan Y; Zhang Y; Tiruppathi C; Loyd JE; Austin ED; Machado RF; Minshall RD; Rehman J; Malik AB; Molecular biology of the cell 2017 Mar 15Loss of lung WWOX expression causes neutrophilic inflammation.
Singla S; Chen J; Sethuraman S; Sysol JR; Gampa A; Zhao S; Machado RF; American journal of physiology. Lung cellular and molecular physiology 2017 Mar 10Reply to Ruan X et al: "A comment on pattern of opioid use in sickle cell disease".
Han J; Saraf SL; Machado RF; Gordeuk VR; American journal of hematology 2017 Feb 7Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension.
Chen J; Sysol JR; Singla S; Zhao S; Yamamura A; Valdez-Jasso D; Abbasi T; Shioura KM; Sahni S; Reddy V; Sridhar A; Gao H; Torres J; Camp SM; Tang H; Ye SQ; Comhair S; Dweik R; Hassoun P; Yuan JX; Garcia JGN; Machado RF; Circulation 2017 Feb 15Inflammation-induced caveolin-1 and BMPRII depletion promotes endothelial dysfunction and TGF-ß-driven pulmonary vascular remodeling.
Oliveira SDS; Castellon M; Chen J; Bonini MG; Gu X; Elliott MH; Machado RF; Minshall RD; American journal of physiology. Lung cellular and molecular physiology 2017 Feb 10Association of circulating transcriptomic profiles with mortality in sickle cell disease.
Desai AA; Lei Z; Bahroos N; Maienschein-Cline M; Saraf SL; Zhang X; Shah BN; Nouraie SM; Abbasi T; Patel AR; Lang RM; Lussier Y; Garcia JGN; Gordeuk VR; Machado RF; Blood 2017 Apr 3Associations of a-thalassemia and BCL11A with stroke in Nigerian, United States, and United Kingdom sickle cell anemia cohorts.
Saraf SL; Akingbola TS; Shah BN; Ezekekwu CA; Sonubi O; Zhang X; Hsu LL; Gladwin MT; Machado RF; Cooper RS; Gordeuk VR; Tayo BO; Blood advances 2017 Apr 25APOL1, a-thalassemia, and BCL11A variants as a genetic risk profile for progression of chronic kidney disease in sickle cell anemia.
Saraf SL; Shah BN; Zhang X; Han J; Tayo BO; Abbasi T; Ostrower A; Guzman E; Molokie RE; Gowhari M; Hassan J; Jain S; Cooper RS; Machado RF; Lash JP; Gordeuk VR; Haematologica 2016 Sep 22Genome-Wide Analysis Identifies IL-18 and FUCA2 as Novel Genes Associated with Diastolic Function in African Americans with Sickle Cell Disease.
Duarte JD; Desai AA; Sysol JR; Abbasi T; Patel AR; Lang RM; Gupta A; Garcia JG; Gordeuk VR; Machado RF; PloS one 2016 Sep 16A genetic variation associated with plasma erythropoietin and a non-coding transcript of PRKAR1A in sickle cell disease.
Zhang X; Shah BN; Zhang W; Saraf SL; Miasnikova G; Sergueeva A; Ammosova T; Niu X; Nouraie M; Nekhai S; Castro O; Gladwin MT; Prchal JT; Garcia JG; Machado RF; Gordeuk VR; Human molecular genetics 2016 Oct 15Associations of Prolonged QTc in Sickle Cell Disease.
Indik JH; Nair V; Rafikov R; Nyotowidjojo IS; Bisla J; Kansal M; Parikh DS; Robinson M; Desai A; Oberoi M; Gupta A; Abbasi T; Khalpey Z; Patel AR; Lang RM; Dudley SC; Choi BR; Garcia JG; Machado RF; Desai AA; PloS one 2016 Oct 13Pulmonary hypertension associated with thalassemia syndromes.
Fraidenburg DR; Machado RF; Annals of the New York Academy of Sciences 2016 Mar 23Pathophysiology and treatment of pulmonary hypertension in sickle cell disease.
Gordeuk VR; Castro OL; Machado RF; Blood 2016 Jan 12Annexin A11 is associated with pulmonary fibrosis in African American patients with sarcoidosis.
Mirsaeidi M; Vu A; Zhang W; Arbieva Z; Zhang C; Abbasi T; Hakim A; Schraufnagel D; Sweiss N; Baughman R; Garcia JG; Machado RF; Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG 2016 Dec 23Expression profiling elucidates a molecular gene signature for pulmonary hypertension in sarcoidosis.
Singla S; Zhou T; Javaid K; Abbasi T; Casanova N; Zhang W; Ma SF; Wade MS; Noth I; Sweiss NJ; Garcia JG; Machado RF; Pulmonary circulation 2016 DecPulmonary vascular and ventricular dysfunction in the susceptible patient (2015 Grover Conference series).
Maron BA; Machado RF; Shimoda L; Pulmonary circulation 2016 DecPatterns of opioid use in sickle cell disease.
Han J; Saraf SL; Zhang X; Gowhari M; Molokie RE; Hassan J; Alhandalous C; Jain S; Younge J; Abbasi T; Machado RF; Gordeuk VR; American journal of hematology 2016 Aug 8Ten tips for managing critically ill patients with sickle cell disease.
Mekontso Dessap A; Fartoukh M; Machado RF; Intensive care medicine 2016 Aug 4PDGF induces SphK1 expression via Egr-1 to promote pulmonary artery smooth muscle cell proliferation.
Sysol JR; Natarajan V; Machado RF; American journal of physiology. Cell physiology 2016 Apr 20Conjunctival and pulmonary hemodynamic properties in sickle cell disease subjects with and without pulmonary hypertension.
Kord Valeshabad A; Wanek J; Molokie RE; Machado RF; Gordeuk VR; Shahidi M; Clinical case reports 2015 Nov 6Endothelial ß-Catenin Signaling Is Required for Maintaining Adult Blood-Brain Barrier Integrity and Central Nervous System Homeostasis.
Tran KA; Zhang X; Predescu D; Huang X; Machado RF; Göthert JR; Malik AB; Valyi-Nagy T; Zhao YY; Circulation 2015 Nov 4Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease.
Zhang X; Zhang W; Saraf SL; Nouraie M; Han J; Gowhari M; Hassan J; Miasnikova G; Sergueeva A; Nekhai S; Kittles R; Machado RF; Garcia JG; Gladwin MT; Steinberg MH; Sebastiani P; McClain DA; Gordeuk VR; Human genetics 2015 May 30The imitation game in pulmonary arterial hypertension. Sex, bone morphogenetic protein receptor, and the estrogen paradox.
Singla S; Machado RF; American journal of respiratory and critical care medicine 2015 Mar 15Genetic variants and cell-free hemoglobin processing in sickle cell nephropathy.
Saraf SL; Zhang X; Shah B; Kanias T; Gudehithlu KP; Kittles R; Machado RF; Arruda JA; Gladwin MT; Singh AK; Gordeuk VR; Haematologica 2015 Jul 23High sodium causes hypertension: evidence from clinical trials and animal experiments.
Reddy V; Sridhar A; Machado RF; Chen J; Journal of integrative medicine 2015 JanResponse.
Mirsaeidi M; Machado RF; Schraufnagel D; Sweiss NJ; Baughman RP; Chest 2015 FebRacial difference in sarcoidosis mortality in the United States.
Mirsaeidi M; Machado RF; Schraufnagel D; Sweiss NJ; Baughman RP; Chest 2015 FebIncreased consumption and vasodilatory effect of nitrite during exercise.
Hon YY; Lin EE; Tian X; Yang Y; Sun H; Swenson ER; Taveira-Dasilva AM; Gladwin MT; Machado RF; American journal of physiology. Lung cellular and molecular physiology 2015 Dec 18[Updated clinical classification of pulmonary hypertension].
Simonneau G; Gatzoulis MA; Adatia I; Celermajer D; Denton C; Ghofrani A; Gomez Sanchez MA; Kumar RK; Landzberg M; Machado RF; Olschewski H; Robbins IM; Souza R; Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 2014 OctDeficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension.
Tang H; Chen J; Fraidenburg DR; Song S; Sysol JR; Drennan AR; Offermanns S; Ye RD; Bonini MG; Minshall RD; Garcia JG; Machado RF; Makino A; Yuan JX; American journal of physiology. Lung cellular and molecular physiology 2014 Nov 21The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.
Chen J; Tang H; Sysol JR; Moreno-Vinasco L; Shioura KM; Chen T; Gorshkova I; Wang L; Huang LS; Usatyuk PV; Sammani S; Zhou G; Raj JU; Garcia JG; Berdyshev E; Yuan JX; Natarajan V; Machado RF; American journal of respiratory and critical care medicine 2014 Nov 1Pulmonary hypertension in sickle cell disease.
Hayes MM; Vedamurthy A; George G; Dweik R; Klings ES; Machado RF; Gladwin MT; Wilson KC; Thomson CC; American Thoracic Society Implementation Task Force.; Annals of the American Thoracic Society 2014 NovMechanistic insights and characterization of sickle cell disease-associated cardiomyopathy.
Desai AA; Patel AR; Ahmad H; Groth JV; Thiruvoipati T; Turner K; Yodwut C; Czobor P; Artz N; Machado RF; Garcia JGN; Lang RM; Circulation. Cardiovascular imaging 2014 Mar 27An official American Thoracic Society clinical practice guideline: diagnosis, risk stratification, and management of pulmonary hypertension of sickle cell disease.
Klings ES; Machado RF; Barst RJ; Morris CR; Mubarak KK; Gordeuk VR; Kato GJ; Ataga KI; Gibbs JS; Castro O; Rosenzweig EB; Sood N; Hsu L; Wilson KC; Telen MJ; Decastro LM; Krishnamurti L; Steinberg MH; Badesch DB; Gladwin MT; American Thoracic Society Ad Hoc Committee on Pulmonary Hypertension of Sickle Cell Disease.; American journal of respiratory and critical care medicine 2014 Mar 15Nontuberculous mycobacterial disease mortality in the United States, 1999-2010: a population-based comparative study.
Mirsaeidi M; Machado RF; Garcia JG; Schraufnagel DE; PloS one 2014 Mar 14Upregulated copper transporters in hypoxia-induced pulmonary hypertension.
Zimnicka AM; Tang H; Guo Q; Kuhr FK; Oh MJ; Wan J; Chen J; Smith KA; Fraidenburg DR; Choudhury MS; Levitan I; Machado RF; Kaplan JH; Yuan JX; PloS one 2014 Mar 10Computed tomography correlates with cardiopulmonary hemodynamics in pulmonary hypertension in adults with sickle cell disease.
Linguraru MG; Pura JA; Gladwin MT; Koroulakis AI; Minniti C; Machado RF; Kato GJ; Wood BJ; Pulmonary circulation 2014 JunRisk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom.
Gladwin MT; Barst RJ; Gibbs JS; Hildesheim M; Sachdev V; Nouraie M; Hassell KL; Little JA; Schraufnagel DE; Krishnamurti L; Novelli E; Girgis RE; Morris CR; Berman Rosenzweig E; Badesch DB; Lanzkron S; Castro OL; Taylor JG 6th; Goldsmith JC; Kato GJ; Gordeuk VR; Machado RF; walk-PHaSST Investigators and Patients.; PloS one 2014 Jul 2Reply: Practice guideline for pulmonary hypertension in sickle cell: direct evidence needed before universal adoption.
Klings ES; Machado RF; Morris CR; Gordeuk VR; Kato GJ; Ataga KI; Castro O; Hsu L; Telen MJ; Krishnamurti L; Steinberg MH; Gladwin MT; ATS Clinical Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension in Sickle Cell Disease Committee.; American journal of respiratory and critical care medicine 2014 Jul 15ARTS: automated randomization of multiple traits for study design.
Maienschein-Cline M; Lei Z; Gardeux V; Abbasi T; Machado RF; Gordeuk V; Desai AA; Saraf S; Bahroos N; Lussier Y; Bioinformatics (Oxford, England) 2014 Feb 3Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease.
Zhang X; Zhang W; Ma SF; Desai AA; Saraf S; Miasniakova G; Sergueeva A; Ammosova T; Xu M; Nekhai S; Abbasi T; Casanova NG; Steinberg MH; Baldwin CT; Sebastiani P; Prchal JT; Kittles R; Garcia JG; Machado RF; Gordeuk VR; Circulation 2014 Feb 10Nicotinamide phosphoribosyltransferase inhibitor is a novel therapeutic candidate in murine models of inflammatory lung injury.
Moreno-Vinasco L; Quijada H; Sammani S; Siegler J; Letsiou E; Deaton R; Saadat L; Zaidi RS; Messana J; Gann PH; Machado RF; Ma W; Camp SM; Wang T; Garcia JG; American journal of respiratory cell and molecular biology 2014 AugEfficacy Results of a 52-week Trial of Adalimumab in the Treatment of Refractory Sarcoidosis.
Sweiss NJ; Noth I; Mirsaeidi M; Zhang W; Naureckas ET; Hogarth DK; Strek M; Caligiuri P; Machado RF; Niewold TB; Garcia JG; Pangan AL; Baughman RP; Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG 2014 Apr 18Effect of extended-release niacin on serum lipids and on endothelial function in adults with sickle cell anemia and low high-density lipoprotein cholesterol levels.
Scoffone HM; Krajewski M; Zorca S; Bereal-Williams C; Littel P; Seamon C; Mendelsohn L; Footman E; Abi-Jaoudeh N; Sachdev V; Machado RF; Cuttica M; Shamburek R; Cannon RO 3rd; Remaley A; Minniti CP; Kato GJ; The American journal of cardiology 2013 Sep 13Pulmonary hypertension associated with chronic hemolytic anemia and other blood disorders.
Machado RF; Farber HW; Clinics in chest medicine 2013 Oct 17A reliable and effective method of DNA isolation from old human blood paper cards.
Song Y; Fahs A; Feldman C; Shah S; Gu Y; Wang Y; Machado RF; Wunderink RG; Chen J; SpringerPlus 2013 Nov 19Differences in the clinical and genotypic presentation of sickle cell disease around the world.
Saraf SL; Molokie RE; Nouraie M; Sable CA; Luchtman-Jones L; Ensing GJ; Campbell AD; Rana SR; Niu XM; Machado RF; Gladwin MT; Gordeuk VR; Paediatric respiratory reviews 2013 Nov 15Pharmacologic treatments for pulmonary hypertension: exploring pharmacogenomics.
Duarte JD; Hanson RL; Machado RF; Future cardiology 2013 MayHematologic and hemorheological determinants of resting and exercise-induced hemoglobin oxygen desaturation in children with sickle cell disease.
Waltz X; Romana M; Lalanne-Mistrih ML; Machado RF; Lamarre Y; Tarer V; Hardy-Dessources MD; Tressières B; Divialle-Doumdo L; Petras M; Maillard F; Etienne-Julan M; Connes P; Haematologica 2013 Mar 28Updated clinical classification of pulmonary hypertension.
Simonneau G; Gatzoulis MA; Adatia I; Celermajer D; Denton C; Ghofrani A; Gomez Sanchez MA; Krishna Kumar R; Landzberg M; Machado RF; Olschewski H; Robbins IM; Souza R; Journal of the American College of Cardiology 2013 Dec 24Haemoglobinuria is associated with chronic kidney disease and its progression in patients with sickle cell anaemia.
Saraf SL; Zhang X; Kanias T; Lash JP; Molokie RE; Oza B; Lai C; Rowe JH; Gowhari M; Hassan J; Desimone J; Machado RF; Gladwin MT; Little JA; Gordeuk VR; British journal of haematology 2013 Dec 12Iron deficiency modifies gene expression variation induced by augmented hypoxia sensing.
Zhang X; Zhang W; Ma SF; Miasniakova G; Sergueeva A; Ammosova T; Xu M; Nekhai S; Nourai M; Wade MS; Prchal JT; Garcia JGN; Machado RF; Gordeuk VR; Blood cells, molecules & diseases 2013 Aug 28MicroRNAs Implicated in Dysregulation of Gene Expression Following Human Lung Transplantation.
Zhang W; Zhou T; Ma SF; Machado RF; Bhorade SM; Garcia JG; Translational respiratory medicine 2013 Aug 1Transcriptional events during the recovery from MRSA lung infection: a mouse pneumonia model.
Chen J; Feng G; Guo Q; Wardenburg JB; Lin S; Inoshima I; Deaton R; Yuan JX; Garcia JG; Machado RF; Otto M; Wunderink RG; PloS one 2013 Aug 1Hemodynamic predictors of mortality in adults with sickle cell disease.
Mehari A; Alam S; Tian X; Cuttica MJ; Barnett CF; Miles G; Xu D; Seamon C; Adams-Graves P; Castro OL; Minniti CP; Sachdev V; Taylor JG 6th; Kato GJ; Machado RF; American journal of respiratory and critical care medicine 2013 Apr 15Circulating endothelial progenitor cells in adults with sickle cell disease.
Rodrigo M; Mendelsohn L; Bereal-Williams C; Hunter L; Dalby CK; McGowan V 2nd; Hunter CJ; Machado RF; McCoy JP; Cannon RO 3rd; Kato GJ; Pulmonary circulation 2013 AprOptimization of isolated perfused/ventilated mouse lung to study hypoxic pulmonary vasoconstriction.
Yoo HY; Zeifman A; Ko EA; Smith KA; Chen J; Machado RF; Zhao YY; Minshall RD; Yuan JX; Pulmonary circulation 2013 AprThe relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe.
Nouraie M; Lee JS; Zhang Y; Kanias T; Zhao X; Xiong Z; Oriss TB; Zeng Q; Kato GJ; Gibbs JS; Hildesheim ME; Sachdev V; Barst RJ; Machado RF; Hassell KL; Little JA; Schraufnagel DE; Krishnamurti L; Novelli E; Girgis RE; Morris CR; Rosenzweig EB; Badesch DB; Lanzkron S; Castro OL; Goldsmith JC; Gordeuk VR; Gladwin MT; Walk-PHASST Investigators and Patients.; Haematologica 2012 Sep 14Peripheral blood gene expression as a novel genomic biomarker in complicated sarcoidosis.
Zhou T; Zhang W; Sweiss NJ; Chen ES; Moller DR; Knox KS; Ma SF; Wade MS; Noth I; Machado RF; Garcia JG; PloS one 2012 Sep 12Reduced sensitivity of the ferroportin Q248H mutant to physiological concentrations of hepcidin.
Nekhai S; Xu M; Foster A; Kasvosve I; Diaz S; Machado RF; Castro OL; Kato GJ; Taylor JG 6th; Gordeuk VR; Haematologica 2012 Oct 12Mortality in adults with sickle cell disease and pulmonary hypertension.
Mehari A; Gladwin MT; Tian X; Machado RF; Kato GJ; JAMA 2012 Mar 28A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease.
Desai AA; Zhou T; Ahmad H; Zhang W; Mu W; Trevino S; Wade MS; Raghavachari N; Kato GJ; Peters-Lawrence MH; Thiruvoipati T; Turner K; Artz N; Huang Y; Patel AR; Yuan JX; Gordeuk VR; Lang RM; Garcia JG; Machado RF; American journal of respiratory and critical care medicine 2012 Jun 7Infrared imaging of nitric oxide-mediated blood flow in human sickle cell disease.
Gorbach AM; Ackerman HC; Liu WM; Meyer JM; Littel PL; Seamon C; Footman E; Chi A; Zorca S; Krajewski ML; Cuttica MJ; Machado RF; Cannon RO 3rd; Kato GJ; Microvascular research 2012 Jul 8Atorvastatin reduces serum cholesterol and triglycerides with limited improvement in vascular function in adults with sickle cell anemia.
Bereal-Williams C; Machado RF; McGowan V 2nd; Chi A; Hunter CJ; Kato GJ; Hunter L; Dalby CK; Hauser KP; Tailor A; Cannon RO 3rd; Haematologica 2012 Jul 6Sphingosine-1-phosphate receptor-3 is a novel biomarker in acute lung injury.
Sun X; Singleton PA; Letsiou E; Zhao J; Belvitch P; Sammani S; Chiang ET; Moreno-Vinasco L; Wade MS; Zhou T; Liu B; Parastatidis I; Thomson L; Ischiropoulos H; Natarajan V; Jacobson JR; Machado RF; Dudek SM; Garcia JG; American journal of respiratory cell and molecular biology 2012 Jul 5Evaluation of a reliable and cost-effective method of DNA isolation for mouse genotyping.
Sysol JR; Kempf C; Helton MN; Dong Y; Zhu D; Sun H; Garcia JG; Machado RF; Chen J; Biotechnology letters 2012 Dec 15Echocardiographic markers of elevated pulmonary pressure and left ventricular diastolic dysfunction are associated with exercise intolerance in adults and adolescents with homozygous sickle cell anemia in the United States and United Kingdom.
Sachdev V; Kato GJ; Gibbs JS; Barst RJ; Machado RF; Nouraie M; Hassell KL; Little JA; Schraufnagel DE; Krishnamurti L; Novelli EM; Girgis RE; Morris CR; Rosenzweig EB; Badesch DB; Lanzkron S; Castro OL; Taylor JG 6th; Hannoush H; Goldsmith JC; Gladwin MT; Gordeuk VR; Walk-PHASST Investigators.; Circulation 2011 Sep 6Pulmonary hypertension in sickle cell disease.
Gladwin MT; Machado RF; The New England journal of medicine 2011 Oct 27Influence of severity of the cutaneous manifestations and age on the prevalence of several cardiovascular risk factors in patients with psoriasis.
Rosa DJ; Machado RF; Matias FA; Cedrim SD; Noronha FL; Gaburri D; Gamonal A; Journal of the European Academy of Dermatology and Venereology : JEADV 2011 May 4NT-pro brain natriuretic peptide levels and the risk of death in the cooperative study of sickle cell disease.
Machado RF; Hildesheim M; Mendelsohn L; Remaley AT; Kato GJ; Gladwin MT; British journal of haematology 2011 Jun 21Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity.
Machado RF; Barst RJ; Yovetich NA; Hassell KL; Kato GJ; Gordeuk VR; Gibbs JS; Little JA; Schraufnagel DE; Krishnamurti L; Girgis RE; Morris CR; Rosenzweig EB; Badesch DB; Lanzkron S; Onyekwere O; Castro OL; Sachdev V; Waclawiw MA; Woolson R; Goldsmith JC; Gladwin MT; walk-PHaSST Investigators and Patients.; Blood 2011 Apr 28Perivascular T-cell infiltration leads to sustained pulmonary artery remodeling after endothelial cell damage.
Cuttica MJ; Langenickel T; Noguchi A; Machado RF; Gladwin MT; Boehm M; American journal of respiratory cell and molecular biology 2010 Sep 2Pulmonary complications of hemoglobinopathies.
Vij R; Machado RF; Chest 2010 OctCategorization and impact of pulmonary hypertension in patients with advanced COPD.
Cuttica MJ; Kalhan R; Shlobin OA; Ahmad S; Gladwin M; Machado RF; Barnett SD; Nathan SD; Respiratory medicine 2010 Jun 14Pulmonary hypertension in hemolytic disorders: pulmonary vascular disease: the global perspective.
Machado RF; Gladwin MT; Chest 2010 JunExercise capacity and haemodynamics in patients with sickle cell disease with pulmonary hypertension treated with bosentan: results of the ASSET studies.
Barst RJ; Mubarak KK; Machado RF; Ataga KI; Benza RL; Castro O; Naeije R; Sood N; Swerdlow PS; Hildesheim M; Gladwin MT; ASSET study group*.; British journal of haematology 2010 Feb 17Diagnosis and management of pulmonary hypertension in systemic sclerosis.
Sweiss NJ; Hushaw L; Thenappan T; Sawaqed R; Machado RF; Patel AR; Gomberg-Maitland M; Husain AN; Archer SL; Current rheumatology reports 2010 FebSegmentation and quantification of pulmonary artery for noninvasive CT assessment of sickle cell secondary pulmonary hypertension.
Linguraru MG; Pura JA; Van Uitert RL; Mukherjee N; Summers RM; Minniti C; Gladwin MT; Kato G; Machado RF; Wood BJ; Medical physics 2010 AprEndothelin receptor antagonists for pulmonary hypertension in adult patients with sickle cell disease.
Minniti CP; Machado RF; Coles WA; Sachdev V; Gladwin MT; Kato GJ; British journal of haematology 2009 Sep 22Identifying chronic obstructive pulmonary disease and asthma by exhaled breath analysis: does the (e)Nose know?
Machado RF; American journal of respiratory and critical care medicine 2009 Dec 1Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death.
Kato GJ; Wang Z; Machado RF; Blackwelder WC; Taylor JG 6th; Hazen SL; British journal of haematology 2008 Mar 17Sodium nitrite promotes regional blood flow in patients with sickle cell disease: a phase I/II study.
Mack AK; McGowan Ii VR; Tremonti CK; Ackah D; Barnett C; Machado RF; Gladwin MT; Kato GJ; British journal of haematology 2008 Jul 11Pulmonary hypertension in patients with bronchiolitis obliterans syndrome listed for retransplantation.
Nathan SD; Shlobin OA; Ahmad S; Barnett SD; Burton NA; Gladwin MT; Machado RF; American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2008 JulPulmonary hypertension: an increasingly recognized complication of hereditary hemolytic anemias and HIV infection.
Barnett CF; Hsue PY; Machado RF; JAMA 2008 Jan 23Pulmonary hypertension in chronic respiratory disorders: we need to learn more.
Machado RF; Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia 2008 FebCT and image processing non-invasive indicators of sickle cell secondary pulmonary hypertension.
Linguraru MG; Orandi BJ; Van Uitert RL; Mukherjee N; Summers RM; Gladwin MT; Machado RF; Wood BJ; Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2008Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin.
Villagra J; Shiva S; Hunter LA; Machado RF; Gladwin MT; Kato GJ; Blood 2007 May 29Hemodynamic and functional assessment of patients with sickle cell disease and pulmonary hypertension.
Anthi A; Machado RF; Jison ML; Taveira-Dasilva AM; Rubin LJ; Hunter L; Hunter CJ; Coles W; Nichols J; Avila NA; Sachdev V; Chen CC; Gladwin MT; American journal of respiratory and critical care medicine 2007 Mar 22Diastolic dysfunction is an independent risk factor for death in patients with sickle cell disease.
Sachdev V; Machado RF; Shizukuda Y; Rao YN; Sidenko S; Ernst I; St Peter M; Coles WA; Rosing DR; Blackwelder WC; Castro O; Kato GJ; Gladwin MT; Journal of the American College of Cardiology 2007 Jan 16Nitric oxide-based therapies in sickle cell disease: the evidence continues to mount.
Machado RF; Critical care medicine 2007 FebN-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease.
Machado RF; Anthi A; Steinberg MH; Bonds D; Sachdev V; Kato GJ; Taveira-DaSilva AM; Ballas SK; Blackwelder W; Xu X; Hunter L; Barton B; Waclawiw M; Castro O; Gladwin MT; MSH Investigators.; JAMA 2006 Jul 19Severity of pulmonary hypertension during vaso-occlusive pain crisis and exercise in patients with sickle cell disease.
Machado RF; Mack AK; Martyr S; Barnett C; Macarthur P; Sachdev V; Ernst I; Hunter LA; Coles WA; Nichols JP; Kato GJ; Gladwin MT; British journal of haematology 2006 Dec 8Combination erythropoietin-hydroxyurea therapy in sickle cell disease: experience from the National Institutes of Health and a literature review.
Little JA; McGowan VR; Kato GJ; Partovi KS; Feld JJ; Maric I; Martyr S; Taylor JG 6th; Machado RF; Heller T; Castro O; Gladwin MT; Haematologica 2006 AugSildenafil in the treatment of pulmonary hypertension.
Barnett CF; Machado RF; Vascular health and risk management 2006Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease.
Kato GJ; McGowan V; Machado RF; Little JA; Taylor J 6th; Morris CR; Nichols JS; Wang X; Poljakovic M; Morris SM Jr; Gladwin MT; Blood 2005 Nov 15Chronic sickle cell lung disease: new insights into the diagnosis, pathogenesis and treatment of pulmonary hypertension.
Machado RF; Gladwin MT; British journal of haematology 2005 MayDetection of lung cancer by sensor array analyses of exhaled breath.
Machado RF; Laskowski D; Deffenderfer O; Burch T; Zheng S; Mazzone PJ; Mekhail T; Jennings C; Stoller JK; Pyle J; Duncan J; Dweik RA; Erzurum SC; American journal of respiratory and critical care medicine 2005 Mar 4Erythrocytes are the major intravascular storage sites of nitrite in human blood.
Dejam A; Hunter CJ; Pelletier MM; Hsu LL; Machado RF; Shiva S; Power GG; Kelm M; Gladwin MT; Schechter AN; Blood 2005 Mar 17Sildenafil therapy in patients with sickle cell disease and pulmonary hypertension.
Machado RF; Martyr S; Kato GJ; Barst RJ; Anthi A; Robinson MR; Hunter L; Coles W; Nichols J; Hunter C; Sachdev V; Castro O; Gladwin MT; British journal of haematology 2005 AugPulmonary hypertension in patients with hemoglobinopathies: could a mechanism for dysfunction provide an avenue for novel therapeutics?
Lin EE; Gladwin MT; Machado RF; Haematologica 2005 AprInhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator.
Hunter CJ; Dejam A; Blood AB; Shields H; Kim-Shapiro DB; Machado RF; Tarekegn S; Mulla N; Hopper AO; Schechter AN; Power GG; Gladwin MT; Nature medicine 2004 Sep 12Nitric oxide and pulmonary arterial pressures in pulmonary hypertension.
Machado RF; Londhe Nerkar MV; Dweik RA; Hammel J; Janocha A; Pyle J; Laskowski D; Jennings C; Arroliga AC; Erzurum SC; Free radical biology & medicine 2004 Oct 1Low levels of nitric oxide and carbon monoxide in alpha 1-antitrypsin deficiency.
Machado RF; Stoller JK; Laskowski D; Zheng S; Lupica JA; Dweik RA; Erzurum SC; Journal of applied physiology (Bethesda, Md. : 1985) 2002 Aug 30Fragmentation-inactivation models with mass loss.
Machado RF; Kamphorst Leal da Silva J; Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics 1995 Dec -
Professional OrganizationsAmerican Society for Clinical InvestigationAmerican Thoracic SocietyPulmonary Hypertension Association
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Board CertificationsAmerican Board of Internal Medicine - Critical Care MedicineAmerican Board of Internal Medicine - Pulmonary DiseaseAmerican Board of Internal Medicine - Internal Medicine
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Clinical Interests
Pulmonary hypertension • Pulmonary complications of sickle cell disease
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AwardsOrg: The American Society for Clinical Investigation
Desc: Elected Member
Scope: National
Date: 1905-07-11