2937-Li, Wei

Wei Li, PhD

Assistant Research Professor of Microbiology & Immunology

MS 266
635 Barnhill Drive

Indianapolis, IN
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Dr. Li received her B.S. in Plant Genetics from Sichuan University, China, in 1983 and PhD in Molecular Genetics from University of Minnesota in 1992. She did her postdoctoral trainings in Virology and Immunology at the Biomedical Research Institute of Children’s Hospital of St. Paul from 1992-1994, University of Minnesota from 1994-1998, and Indiana University from 2003 to 2005. She became a Research Assistant Professor in the Department of Microbiology and Immunology in 2005. Her research interests include T cell biology (development, differentiation, and tolerance) and human and mouse immune responses in infectious and inflammatory diseases. To date, she has published 34 scientific papers.

Key Publications

Titles & Appointments

  • Assistant Research Professor of Microbiology & Immunology
  • Research Assistant Professor
  • Education
    1992 PhD University of Minnesota
    1983 BS Sichuan University
  • Research

    Summary of the focus of the research

    My research focuses on chronic immune activation, inflammation, and microbial translocation in patients with alcoholic hepatitis and HIV


    Description and summary of research focus of the laboratory

    Long-term heavy drinkers develop a spectrum of severe alcoholic liver disease, including alcoholic hepatitis, a severe and progressive liver inflammatory disease associated with significant morbidity and mortality. Excessive alcohol ingestion leads to increased intestinal permeability and microbial translocation from the gastrointestinal tract into the liver, which activates the immune system and plays a major role in the pathogenesis of alcoholic hepatitis. HIV infection also damages the gastrointestinal tract mucosal barrier, leading to microbial translocation and chronic immune activation and inflammation, which is not fully reversed by antiretroviral therapy. Alcohol abuse is prevalent among HIV-infected individuals. However it is not well known how excessive alcohol consumption and HIV infection interact to affect microbial translocation, immune activation, inflammation, and viral replication. I am interested in understanding the effect of alcohol on the immunological and virological features in HIV patients. As alcohol abstinence is the most important aspect for treating alcoholic liver diseases, I am examining whether alcohol abstinence could reverse immunological and virological impacts in HIV-infected heavy drinkers.

  • Publications
    Glucose level decline precedes dementia in elderly African Americans with diabetes.
    Hendrie HC; Zheng M; Li W; Lane K; Ambuehl R; Purnell C; Unverzagt FW; Torke A; Balasubramanyam A; Callahan CM; Gao S; Alzheimer's & dementia : the journal of the Alzheimer's Association 2016 Oct 25
    Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
    Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Acevedo Arozena A; Adachi H; Adams CM; Adams PD; Adeli K; Adhihetty PJ; Adler SG; Agam G; Agarwal R; Aghi MK; Agnello M; Agostinis P; Aguilar PV; Aguirre-Ghiso J; Airoldi EM; Ait-Si-Ali S; Akematsu T; Akporiaye ET; Al-Rubeai M; Albaiceta GM; Albanese C; Albani D; Albert ML; Aldudo J; Algül H; Alirezaei M; Alloza I; Almasan A; Almonte-Beceril M; Alnemri ES; Alonso C; Altan-Bonnet N; Altieri DC; Alvarez S; Alvarez-Erviti L; Alves S; Amadoro G; Amano A; Amantini C; Ambrosio S; Amelio I; Amer AO; Amessou M; Amon A; An Z; Anania FA; Andersen SU; Andley UP; Andreadi CK; Andrieu-Abadie N; Anel A; Ann DK; Anoopkumar-Dukie S; Antonioli M; Aoki H; Apostolova N; Aquila S; Aquilano K; Araki K; Arama E; Aranda A; Araya J; Arcaro A; Arias E; Arimoto H; Ariosa AR; Armstrong JL; Arnould T; Arsov I; Asanuma K; Askanas V; Asselin E; Atarashi R; Atherton SS; Atkin JD; Attardi LD; Auberger P; Auburger G; Aurelian L; Autelli R; Avagliano L; Avantaggiati ML; Avrahami L; Awale S; Azad N; Bachetti T; Backer JM; Bae DH; Bae JS; Bae ON; Bae SH; Baehrecke EH; Baek SH; Baghdiguian S; Bagniewska-Zadworna A; Bai H; Bai J; Bai XY; Bailly Y; Balaji KN; Balduini W; Ballabio A; Balzan R; Banerjee R; Bánhegyi G; Bao H; Barbeau B; Barrachina MD; Barreiro E; Bartel B; Bartolomé A; Bassham DC; Bassi MT; Bast RC Jr; Basu A; Batista MT; Batoko H; Battino M; Bauckman K; Baumgarner BL; Bayer KU; Beale R; Beaulieu JF; Beck GR Jr; Becker C; Beckham JD; Bédard PA; Bednarski PJ; Begley TJ; Behl C; Behrends C; Behrens GM; Behrns KE; Bejarano E; Belaid A; Belleudi F; Bénard G; Berchem G; Bergamaschi D; Bergami M; Berkhout B; Berliocchi L; Bernard A; Bernard M; Bernassola F; Bertolotti A; Bess AS; Besteiro S; Bettuzzi S; Bhalla S; Bhattacharyya S; Bhutia SK; Biagosch C; Bianchi MW; Biard-Piechaczyk M; Billes V; Bincoletto C; Bingol B; Bird SW; Bitoun M; Bjedov I; Blackstone C; Blanc L; Blanco GA; Blomhoff HK; Boada-Romero E; Böckler S; Boes M; Boesze-Batt Autophagy 2016
  • Professional Organizations
    American Association of Immunologists
  • Clinical Interests


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