27429-Hodge, Jennelle
Faculty

Jennelle C. Hodge, PhD

Professor of Clinical Medical & Molecular Genetics

Address
975 W. Walnut Street
IB-354

Indianapolis, IN 46202
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Bio


Jennelle C. Hodge, Ph.D., board certified in ABMGG Clinical Cytogenetics and Molecular Genetics and Genomics, is a director in the Cytogenetics, Molecular Genetics and Pharmacogenomics laboratories and a Professor in the Department of Medical and Molecular Genetics at Indiana University. Her translational research focuses on cancer genetics and mining of genomic data for genotype and phenotype correlation. Dr. Hodge is currently a Standing Editor for the WHO Classification of Tumours (WCT) and the Chair of the Genetics and Genomics Subcommittee. She is also the Editor-in-Chief for the Compendium of Cancer Genome Aberrations (CCGA.io); this wiki-style resource aims to provide up-to-date information on the genetic correlates to the WCT-based diseases for laboratory cancer case interpretation. Additionally, Dr. Hodge has had leadership roles in clinical genetics-focused organizations (American College of Medical Genetics and Genomics, Association for Molecular Pathology, and Cancer Genomics Consortium), and contributed to diverse academic endeavors including high-impact publications in journals such as Cell and Nature Genetics. Her goals are to support the next generation of clinical scientists and produce resources for the genetics community.

Key Publications

Hodge JC, Mitchell E, Pillalamarri V, Toler TL, Bartel F, Kearney HM, Zou YS, Tan W-H, Hanscom C, Kirmani S, Hanson RR, Skinner SA, Rogers C, Everman DB, Boyd E, Mullegama SV, Keelean-Fuller D, Powell CM, Elsea SH, Morton CC, Gusella JF, DuPont B, Chaubey A, Lin AE, Talkowski ME. Disruption of MBD5 contributes to a spectrum of psychopathology and neurodevelopmental abnormalities. Mol Psych. 19(3):368-379, 2014.

Hodge JC, Pearce KE, Wang X, Wiktor AE, Oliveria AM, Greipp, PR. Molecular cytogenetic analysis for TFE3 rearrangement in Xp11.2 renal cell carcinoma and alveolar soft part sarcoma: Validation and extensive clinical experience with 75 cases. Modern Pathol. 27(1):113-127, 2014.

Hodge JC, Pearce KE, Clayton AC, Taran FA, Stewart EA. Uterine cellular leiomyomata with chromosome 1p deletions represent a distinct entity. Am J Obstet Gynecol 210(6):572.e1-e7, 2014.

Hand J, Runke C, Hodge JC. The phenotype spectrum of X-linked ichthyosis identified by chromosomal microarray. J Am Acad Dermatol 72(4):617-627, 2015.

Hodge JC, Bedroske PB, Pearce KE, Sukov WR. Molecular cytogenetic analysis of JAZF1, PHF1 and YWHAE in endometrial stromal tumors: Discovery of genetic complexity by FISH. J Mol Diag 18(4):516-526, 2016.

Redin C, Brand H, Collins RL, Kammin T, Mitchell E, Hodge JC, et al. The Genomic Landscape of Balanced Cytogenetic Abnormalities Associated with Congenital Anomalies. Nat Genet 49(1):36-45, 2017.

Kanagal-Shamanna R, Hodge JC, et al. Assessing copy number alterations and copy neutral loss of heterozygosity across the genome as best practice: an evidence based review of clinical utility from the Cancer Genomics Consortium (CGC) working group for myelodysplastic syndrome, myelodysplastic/myeloproliferative and myeloproliferative neoplasms. Cancer Genetics 228-229:197-217, 2018.

Hodge JC, Bosler D, Rubinstein L, Shetty S. Molecular and pathologic characterization of AML with double inv(3)(q21q26.2). Cancer Genetics 230:28-36, 2019.

Khoury J, Solary E, Abla O, Akkari Y, Alaggio R, Apperley J, Bejar R, Berti E, Busque L, Chan JKC, Chen W, Chen X, Chng WJ, Choi J, Colmenero I, Coupland S, Cross N, de Jong D, Elghetany MT, Takahashi E, Emile J-F, Ferry J, Fogelstrand L, Fontenay M, Germing U, Gujral S, Haferlach T, Harrison C, Hodge JC, Hu S, Jansen J, Kanagal-Shamanna R, Kantarjian H, Kratz C, Li X, Lim M, Loeb K, Loghavi S, Marcogliese A, Meshinchi S, Michaels P, Naresh K, Natkunam Y, Nejati R, Ott G, Padron E, Patel K, Patkar N, Picarsic J, Platzbecker U, Roberts I, Schuh A, Sewell W, Siebert R, Tembhare P, Tyner J, Verstovsek S, Wang W, Wood B, Xiao W, Yeung C, Hochhaus A. Leukemia. The 5th Edition of The World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms. Leukemia. 36(7):1703-1719, 2022.

Collins RL, Glessner JT, Porcu E, Lepamets M, Brandon R, Lauricella C, Han L, Morely T, Niestroj L-M, Ulirsch J, Everett S, Howrigan DP, Boone1 PM, Fu1 J, Karczewski K, Kellaris G, Lowther C, Lucente D, Mohajeri K, Nõukas M, Nuttle X, Samocha KE, Trinh M,  Ullah F, Võsa U, Epi25 Consortium, Estonian Biobank Research Team, Hurles ME, Aradhya S, Davis EE, Finucane H, Gusella JF, Janze A, Katsanis N, Matyakhina L, Neal BM, Sanders D, Warren S, Hodge JC, Lal D, Ruderfer DM, Meck J, Mägi R, Esko T, Reymond A, Kutalik Z, Hakonarson H, Sunyaev S, Brand H, Talkowski ME. A cross-disorder dosage sensitivity map of the human genome. Cell. 185(16):3041-3055.e25, 2022.

Milman T, Grossniklaus HE, Goldman-Levy, G, Kivelä T, Coupland SE, White VA, Mudhahar H, Eberhart CG, Verdijk, RM, Heegaard S, Gill AJ, Jager MJ, Rodriguez AA, Esmaeli B, Hodge JC, Cree IA. The 5th edition of the World Health Organization Classification of Tumours of the Eye and Orbit. Ocular Oncology and Pathology.  In Press.

Landis BJ, Elmore LR, Geddes GC, Lin J-H, Yatsenko SA, Lo C, Border WL, Wechsler SB, Murali CN, Lalani SR, Hinton RB, Garg V, McBride KL, Hodge JC, Ware SM. A multicenter analysis of abnormal chromosomal microarray findings in congenital heart disease. Journal of the American Heart Association. 12(18):e029340, 2023.

Lowther C, Valkanas E, Giordano JL, Wang HZ, Currall BB O’Keefe K, Pierce-Hoffman E, Kurtas NE, Whelan CW, Hao SP, Weisburd BW, Jalili V, Fu J, Wong I, Collins RL, Zhao X, Austin-Tse CA, Evangelista E, Lemire G, Aggarwal VS, Lucente D, Gauthier LD, Tolonen C, Sahakian N, Stevens, C, An J-Y, Dong S, Norton ME, Mackenzie T, Devlin B, Gilmore K, Powell BC, Brandt A, Vetrini F, DiVito M, Sanders SJ, MacArthur DG, Hodge JC, O'Donnell-Luria AH, Rehm HL, Vora NL, Levy B, Brand H, Wapner R, Talkowski ME. Systematic evaluation of genome sequencing for the diagnostic assessment of autism spectrum disorder and fetal structural anomalies. Am J Hum Genet. 110(9):1454-1469, 2023.

Shugg T, Ly RC, Osei W, Rowe EJ, Granfield CA, Lynnes TC, Medeiros EB, Hodge JC, Breman AM, Schneider BP, Sahinalp SC, Numanagic I, Salisbury BA, Bray SM, Ratcliff R, Skaar TC. Computational pharmacogenotype extraction from clinical next-generations sequencing. Frontiers Oncology. 13:1199741, 2023.

Titles & Appointments

  • Professor of Clinical Medical & Molecular Genetics
  • Co-Director, Cytogenetics Laboratory
  • Associate Director, Molecular Genetics Diagnostic Laboratory
  • Education
    2014 Residency California State Department of Health Services
    2013 Residency California State Department of Health Services
    2009 Residency New York State Department of Health
    2007 Residency Brigham and Women's Hospital
    2006 Residency Harvard Medical School
    2005 Residency Harvard Medical School
    2003 PhD Medical College of Wisconsin
    1999 BS Rochester Institute of Technology
  • Research

    My research interests include development and implementation of innovative technologies for molecular and cytogenomic clinical diagnostics, mining of genomic data for genotype and phenotype correlation, exploring the genetics of cancer, and creating open-sourced resources for the genomics community.

  • Professional Organizations
    American Board of Medical Genetics and Genomics (ABMGG)
    American College of Medical Genetics and Genomics (ACMG)
    American Society of Human Genetics (ASHG)
    Association of Molecular Pathologists (AMP)
    Cancer Genomics Consortium (CGC)
  • Board Certifications
    American Board of Medical Genetics and Genomics - Clinical Cytogenetics and Genomics*
    American Board of Medical Genetics and Genomics - Clinical Molecular Genetics and Genomics*
  • Clinical Interests
    Dr. Hodge's clinical interests include molecular genetics, cytogenetics, and pharmacogenetics.
  • Awards
    Org:
    Desc: Trustee Teaching Award
    Scope: University
    Date: 2021-05-01

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