Dr. Landreth received his undergraduate degree in Chemistry and Biochemistry from the University of Kansas in 1972. He then completed a Ph.D. in the Neuroscience Program at the University of Michigan, including a year of study at the National Institute of Medical Research in London. He carried out postdoctoral work in the Department of Neurobiology at Stanford with Dr. Eric Shooter. Dr. Landreth was appointed to the faculty of the Medical University of South Carolina in 1980, where he worked for 9 years. He moved to Case Western Reserve University Department of Neurosciences and directed the Alzheimer Research Laboratory from 1989 until 2016. He is presently on the faculty of the University of Indiana School of Medicine and Stark Neurosciences Research Institute.
Dr. Landreth’s work over the past 20 years has focused the principal genetic risk factors for Alzheimer’s disease. The laboratory has focused on the biology of ApoE, its role in amyloid homeostasis and the regulation of its expression by nuclear receptors. The laboratory has also investigated inflammatory mechanisms in Alzheimer’s disease and the biology of microglia. Recent work has examined the mechanisms through which TREM2 influences disease pathogenesis. The laboratory maintains a focus on drug development for CNS disorders, including Alzheimer’s disease.