271-Philips, Santosh
Faculty

Santosh Philips, PHD

Assistant Scientist in Medicine

Bio

Dr. Philips works at the intersection of pharmacy, pharmacogenomics and informatics. His research experience spans multiple domains and he has been successful in identifying and validating novel drug interactions, drugs with the potential of being repurposed, variants that significantly impact gene activity, and genes that are crucial for cell survival by implementing machine learning algorithms. Dr. Philips has made significant contributions to several research projects and has over 30 peer reviewed publications. His current research is mainly focused on developing pipelines to discover informative biomarkers and building predictive tools to identify individuals who may be susceptible to severe adverse effects of chemotherapeutic drugs. Dr. Philips is passionate about using his diverse background and experience to develop innovative solutions that can address the challenges faced in precision medicine.

Key Publications

Philips, S., Wu, H.Y., and Li, L., Using machine learning algorithms to identify genes essential for cell survival. BMC Bioinformatics, 2017.

Hertz, D.L., Kidwell, K.M., Hilsenbeck, S.G., Oesterreich, S., Osborne, C.K., Philips, S., Chenault, C., Hartmaier, R.J., Skaar, T.C., Sikora, M.J., and Rae, J.M., CYP2D6 genotype is not associated with survival in breast cancer patients treated with tamoxifen: Results from a population-based study. Breast Cancer Res Treat, 2017.

Berlacher, M., Mastouri, R., Philips, S., Skaar, T.C., and Kreutz, R.P., Common genetic polymorphisms of adenosine A2A receptor do not influence response to regadenoson. Pharmacogenomics, 2017.

Santa-Maria, C.A., Blackford, A., Nguyen, A.T., Skaar, T.C., Philips, S., Oesterreich, S., Rae, J.M., Desta, Z., Robarge, J., Henry, N.L., Storniolo, A.M., Hayes, D.F., Blumenthal, R.S., Ouyang, P., Post, W.S., Flockhart, D.A., Stearns, V., and Consortium on Breast Cancer, P., Association of variants in candidate genes with lipid profiles in women with early breast cancer on adjuvant aromatase inhibitor therapy. Clin Cancer Res, 2016.

Saab, R., Zouk, A.N., Mastouri, R., Skaar, T.C., Philips, S., and Kreutz, R.P., AMPD1 polymorphism and response to regadenoson. Pharmacogenomics, 2015.

Philips, S., Zhou, J., Li, Z., Skaar, T.C., and Li, L., A translational bioinformatic approach in identifying and validating an interaction between vitamin A and CYP19A1. BMC Genomics, 2015.

Oesterreich, S., Henry, N.L., Kidwell, K.M., Van Poznak, C.H., Skaar, T.C., Dantzer, J., Li, L., Hangartner, T.N., Peacock, M., Nguyen, A.T., Rae, J.M., Desta, Z., Philips, S., Storniolo, A.M., Stearns, V., Hayes, D.F., and Flockhart, D.A., Associations between genetic variants and the effect of letrozole and exemestane on bone mass and bone turnover. Breast Cancer Res Treat, 2015.

Burgess, K.S., Philips, S., Benson, E.A., Desta, Z., Gaedigk, A., Gaedigk, R., Segar, M.W., Liu, Y., and Skaar, T.C., Age-related changes in microRNA expression and pharmacogenes in human liver. Clin Pharmacol Ther, 2015.

Wu, H.Y., Karnik, S., Subhadarshini, A., Wang, Z., Philips, S., Han, X., Chiang, C., Liu, L., Boustani, M., Rocha, L.M., Quinney, S.K., Flockhart, D., and Li, L., An integrated pharmacokinetics ontology and corpus for text mining. BMC Bioinformatics, 2013.

Weng, L., Ziliak, D., Im, H.K., Gamazon, E.R., Philips, S., Nguyen, A.T., Desta, Z., Skaar, T.C., Consortium on Breast Cancer, P., Flockhart, D.A., and Huang, R.S., Genome-wide discovery of genetic variants affecting tamoxifen sensitivity and their clinical and functional validation. Ann Oncol, 2013.

Ramamoorthy, A., Liu, Y., Philips, S., Desta, Z., Lin, H., Goswami, C., Gaedigk, A., Li, L., Flockhart, D.A., and Skaar, T.C., Regulation of microRNA expression by rifampin in human hepatocytes. Drug Metab Dispos, 2013.

Henry, N.L., Skaar, T.C., Dantzer, J., Li, L., Kidwell, K., Gersch, C., Nguyen, A.T., Rae, J.M., Desta, Z., Oesterreich, S., Philips, S., Carpenter, J.S., Storniolo, A.M., Stearns, V., Hayes, D.F., and Flockhart, D.A., Genetic associations with toxicity-related discontinuation of aromatase inhibitor therapy for breast cancer. Breast Cancer Res Treat, 2013.

Henry, N.L., Chan, H.P., Dantzer, J., Goswami, C.P., Li, L., Skaar, T.C., Rae, J.M., Desta, Z., Khouri, N., Pinsky, R., Oesterreich, S., Zhou, C., Hadjiiski, L., Philips, S., Robarge, J., Nguyen, A.T., Storniolo, A.M., Flockhart, D.A., Hayes, D.F., Helvie, M.A., and Stearns, V., Aromatase inhibitor-induced modulation of breast density: Clinical and genetic effects. Br J Cancer, 2013.

Haas, D.M., Dantzer, J., Lehmann, A.S., Philips, S., Skaar, T.C., McCormick, C.L., Hebbring, S.J., Jung, J., and Li, L., The impact of glucocorticoid polymorphisms on markers of neonatal respiratory disease after antenatal betamethasone administration. Am J Obstet Gynecol, 2013.

Philips, S., Richter, A., Oesterreich, S., Rae, J.M., Flockhart, D.A., Perumal, N.B., and Skaar, T.C., Functional characterization of a genetic polymorphism in the promoter of the esr2 gene. Horm Cancer, 2012.

Philips, S., Rae, J.M., Oesterreich, S., Hayes, D.F., Stearns, V., Henry, N.L., Storniolo, A.M., Flockhart, D.A., and Skaar, T.C., Whole genome amplification of DNA for genotyping pharmacogenetics candidate genes. Front Pharmacol, 2012.

Hartmaier, R.J., Richter, A.S., Gillihan, R.M., Sallit, J.Z., McGuire, S.E., Wang, J., Lee, A.V., Osborne, C.K., O'Malley, B.W., Brown, P.H., Xu, J., Skaar, T.C., Philips, S., Rae, J.M., Azzouz, F., Li, L., Hayden, J., Henry, N.L., Nguyen, A.T., Stearns, V., Hayes, D.F., Flockhart, D.A., and Oesterreich, S., A SNP in steroid receptor coactivator-1 disrupts a GSK3beta phosphorylation site and is associated with altered tamoxifen response in bone. Mol Endocrinol, 2012.

Haas, D.M., Lehmann, A.S., Skaar, T., Philips, S., McCormick, C.L., Beagle, K., Hebbring, S.J., Dantzer, J., Li, L., and Jung, J., The impact of drug metabolizing enzyme polymorphisms on outcomes after antenatal corticosteroid use. Am J Obstet Gynecol, 2012.

Yoon, H.H., Catalano, P.J., Murphy, K.M., Skaar, T.C., Philips, S., Powell, M., Montgomery, E.A., Hafez, M.J., Offer, S.M., Liu, G., Meltzer, S.J., Wu, X., Forastiere, A.A., Benson, A.B., Kleinberg, L.R., and Gibson, M.K., Genetic variation in DNA-repair pathways and response to radiochemotherapy in esophageal adenocarcinoma: A retrospective cohort study of the eastern cooperative oncology group. BMC Cancer, 2011.

Yoon, H.H., Catalano, P.J., Murphy, K.M., Skaar, T.C., Philips, S., Powell, M., Montgomery, E.A., Hafez, M.J., Offer, S.M., Liu, G., Meltzer, S.J., Wu, X., Forastiere, A.A., Benson, A.B., Kleinberg, L.R., and Gibson, M.K., Genetic variation in DNA-repair pathways and response to radiochemotherapy in esophageal adenocarcinoma: A retrospective cohort study of the eastern cooperative oncology group. BMC Cancer, 2011.

Yoon, H.H., Catalano, P., Gibson, M.K., Skaar, T.C., Philips, S., Montgomery, E.A., Hafez, M.J., Powell, M., Liu, G., Forastiere, A.A., Benson, A.B., Kleinberg, L.R., and Murphy, K.M., Genetic variation in radiation and platinum pathways predicts severe acute radiation toxicity in patients with esophageal adenocarcinoma treated with cisplatin-based preoperative radiochemotherapy: Results from the eastern cooperative oncology group. Cancer Chemother Pharmacol, 2011.

Haas, D.M., Daum, M., Skaar, T., Philips, S., Miracle, D., and Renbarger, J.L., Human breast milk as a source of DNA for amplification. J Clin Pharmacol, 2011.

Henry, N.L., Nguyen, A., Azzouz, F., Li, L., Robarge, J., Philips, S., Cao, D., Skaar, T.C., Rae, J.M., Storniolo, A.M., Flockhart, D.A., Hayes, D.F., and Stearns, V., Lack of association between oestrogen receptor polymorphisms and change in bone mineral density with tamoxifen therapy. Br J Cancer, 2010.

Hayes, D.F., Skaar, T.C., Rae, J.M., Henry, N.L., Nguyen, A.T., Stearns, V., Li, L., Philips, S., Desta, Z., Flockhart, D.A., and Consortium on Breast Cancer, P., Estrogen receptor genotypes, menopausal status, and the effects of tamoxifen on lipid levels: Revised and updated results. Clin Pharmacol Ther, 2010.

Borges, S., Desta, Z., Jin, Y., Faouzi, A., Robarge, J.D., Philips, S., Nguyen, A., Stearns, V., Hayes, D., Rae, J.M., Skaar, T.C., Flockhart, D.A., and Li, L., Composite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients. J Clin Pharmacol, 2010.

Henry, N.L., Rae, J.M., Li, L., Azzouz, F., Skaar, T.C., Desta, Z., Sikora, M.J., Philips, S., Nguyen, A.T., Storniolo, A.M., Hayes, D.F., Flockhart, D.A., Stearns, V., and Consortium on Breast Cancer Pharmacogenomics, I., Association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort. Breast Cancer Res Treat, 2009.

Carpenter, J.S., Yu, M., Wu, J., Von Ah, D., Milata, J., Otte, J.L., Johns, S., Schneider, B., Storniolo, A.M., Salomon, R., Desta, Z., Cao, D., Jin, Y., Philips, S., and Skaar, T.C., Evaluating the role of serotonin in hot flashes after breast cancer using acute tryptophan depletion. Menopause, 2009.

Arefayene, M., Philips, S., Cao, D., Mamidipalli, S., Desta, Z., Flockhart, D.A., Wilkes, D.S., and Skaar, T.C., Identification of genetic variants in the human indoleamine 2,3-dioxygenase (IDO1) gene, which have altered enzyme activity. Pharmacogenet Genomics, 2009.

Jin, Y., Hayes, D.F., Li, L., Robarge, J.D., Skaar, T.C., Philips, S., Nguyen, A., Schott, A., Hayden, J., Lemler, S., Storniolo, A.M., Flockhart, D.A., and Stearns, V., Estrogen receptor genotypes influence hot flash prevalence and composite score before and after tamoxifen therapy. J Clin Oncol, 2008.

Bharucha, A.E., Skaar, T., Andrews, C.N., Camilleri, M., Philips, S., Seide, B., Burton, D., Baxter, K., and Zinsmeister, A.R., Relationship of cytochrome p450 pharmacogenetics to the effects of yohimbine on gastrointestinal transit and catecholamines in healthy subjects. Neurogastroenterol Motil, 2008.

Jin, Y., Wang, Y.H., Miao, J., Li, L., Kovacs, R.J., Marunde, R., Hamman, M.A., Philips, S., Hilligoss, J., and Hall, S.D., Cytochrome p450 3A5 genotype is associated with verapamil response in healthy subjects. Clin Pharmacol Ther, 2007.

Titles & Appointments

  • Assistant Scientist in Medicine
  • Education
    2016 PhD Indiana University
    2016 PHD Indiana University
    2016 PHD Indiana University
    2004 MS Indiana University
    2004 MS Indiana University
    2004 MS Indiana University
    1999 BS Bangalore University
    1999 BS M.S. Ramaiah Medical College
    1999 BS M.S. Ramaiah Medical College
  • Research

    Identifying biomarkers and developing predictive tools to help guide personalized therapy

  • Professional Organizations
    American Medical Informatics Association
  • Clinical Interests

    Precision Oncology

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