26760-Liu, Shaohui
Faculty

Shaohui Liu, PhD, MD

Associate Professor of Clinical Ophthalmology

Address
Glick Eye Institute, Suite 213
1160 W Michigan St

Indianapolis, IN 46202

Bio

Dr. Shaohui Liu is a board certified ophthalmologist and corneal specialist. She obtained her medical degree and PhD degree from Medical College of Qingdao University in China.  She further pursued postdoctoral research fellowship at the Schepens Eye Research Institute, Harvard Medical School. She made significant achievements in research including a patent for dry eye syndrome which was licensed to a major pharmaceutical company.

She completed her ophthalmology residency training in Louisiana State University Health Science Center in Shreveport, Louisiana, followed by clinical fellowship in Cornea, Refractive Surgery and External Disease at the Massachusetts Eye & Ear Infirmary, Harvard Medical School.  

Key Publications

Liu S, Li J, Wang CF, Tan D, Beuerman R. Human Limbal Progenitor Cell Characteristics are maintained in Tissue Culture. Ann Acad Med Singapore, 2006; 35:80-6.

Liu S, Li J, Tan D, Beuerman R. The Eyelid Margin: A Transitional Zone for Two Epithelial Phenotypes. Arch Ophthalm. 2007 Apr;125(4):523-32.

Liu S, Li J, Tan D, Beuerman R. Expression and Function of Muscarinic Receptor Subtypes on Human Cornea and Conjunctiva. Invest Ophthalmol Vis Sci. 2007 Jul;48(7):2987-96. 

Suzuki T, Richards SM, Liu S, Jensen RV, Sullivan DA.  Influence of sex on gene expression in human epithelial cells. Mol Vis. 2009;15:2554-69.

Liu S, Hatton MP, Khandelwal P, Sullivan DA. Culture Immortalization and Characterization of Human Meibomian Gland Epithelial Cells. Invest Ophthalmol Vis Sci. 2010 Aug;51(8):3993-4005.

Liu S, Richards SM, Lo K, Hatton M, Fay A, Sullivan DA. Changes in gene expression in human meibomian gland dysfunction. Invest Ophthalmol Vis Sci. 2011 Apr 25;52(5):2727-40.

Khandelwal P, Liu S, Sullivan DA. Androgen regulation of gene expression in human meibomian gland and conjunctival epithelial cells. Mol Vis. 2012;18:1055-67.

Liu S, Pavan-Langston D, Colby KA. Pediatric herpes simplex of the anterior segment: characteristics, treatment, and outcomes. Ophthalmology. 2012 Oct;119(10):2003-8.

Darabad RR, Suzuki T, Richards SM, Jensen RV, Jakobiec FA, Zakka FR, Liu S, Sullivan DA. Influence of aromatase absence on the gene expression and histology of the mouse meibomian gland.  Invest Ophthalmol Vis Sci. 2013 Feb 5;54(2):987-98

Liu S, Kam WR, Ding J, Hatton MP, Sullivan DA. Effect of growth factors on the proliferation and gene expression of human meibomian gland epithelial cells. Invest Ophthalmol Vis Sci. 2013 Apr 5;54(4):2541-50

Schmidt TA, Sullivan DA, Knop E, Richards SM, Knop N, Liu S, Sahin A, Darabad RR, Morrison S, Kam WR, Sullivan BD. Transcription, Translation, and Function of Lubricin, a Boundary Lubricant, at the Ocular Surface. JAMA Ophthalmol. 2013 Apr 18:1-11

Liu S, Sun LL, Kavanaugh AS, Langford MP, Liang C. Recurrent annular peripheral choroidal detachment after trabeculectomy. Case Rep Ophthalmol. 2013 Oct 24;4(3):192-8.

Sullivan DA, Liu Y, Kam WR, Ding J, Green KM, Shaffer SR, Hatton MP, Liu S. Serum-induced differentiation of human meibomian gland epithelial cells. Invest Ophthalmol Vis Sci. 2014 May 27;55(6):3866-77.

Liu S, Veldman P. Evidence Based Endothelial Rehabilitation. Semin Ophthalmol. 2017;32(1):96-103.

Janbatian HY, Fadlallah A, Liu S, Chu T, Melki S. Femtosecond-assisted LASIK flaps resistant to lift secondary to corneal epithelial defects: case reports and ex vivo studies. J Cataract Refract Surg. 2018 Dec;44(12):1503-1506.

Isidan A, Liu S, Li P, Lashmet M, Smith LJ, Hara H, Cooper DKC, Ekser B. Decellularization methods for developing porcine corneal xenografts and future perspectives.  Xenotransplantation. 2019 Nov;26(6):e12564.

Chen X, Sullivan BD, Daradad RR, Liu S, Kim WR, Sullivan DA.  Are BALB/c mice relevant models for understanding sex-related differences in gene expression in the human meibomian gland? Cornea. 2019 Dec; 38 (12), 1554-1562.

Chuang K, MD, Vortmeyer A, MD, Liu S. Conjunctival Fungal Ball Mimicking Melanoma. Ophthalmology. 2020 Apr;127(4):534.

Fox A, Pineda R, Liu S. Spontaneously Regressed Corneal Intrastromal Cyst. Ophthalmology. 2020 Oct; 127(10):1383.  

Isidan A, Liu S, Chen AM, Zhang W, Li P, Smith LJ, Hara H, Cooper DKC, Ekser B. Comparison of porcine corneal decellularization methods and importance of preserving corneal limbus through decellularization. PLoS One. 2021 Mar 5;16(3):e0243682.  

Sugali CK, Rayana NP, Dai J, Peng M, Harris SL, Webber HC, Liu S, Dixon SG, Parekh PH, Martin EA, Cantor LB, Fellman RL, Godfrey DG, Butler MR, Emanuel ME, Grover DS, Smith OU, Clark AF, Raghunathan VK, Mao W. The canonical Wnt signaling pathway inhibits the glucocorticoid receptor signaling pathway in the trabecular meshwork. Am J Pathol. 2021 Jun;191(6):1020-1035.

 Rayana NP, Sugali CK, Dai J, Peng M, Liu S, Zhang Y, Wan J, Mao W. Using CRISPR Interference as a Therapeutic Approach to Treat TGFβ2-Induced Ocular Hypertension and Glaucoma. Invest Ophthalmol Vis Sci. 2021 Sep 2;62(12):7. doi: 10.1167/iovs.62.12.7.

Chuang K, Pineda R, Liu S. Belantamab Mafodotin Associated Corneal Microcyst-like Changes. Am J Ophthalmol Case Rep. 2022 Feb.2;25:101392.

Titles & Appointments

  • Associate Professor of Clinical Ophthalmology
  • Education
    2016 FEL Fellowship in Cornea, Refractive Surgery and External Disease, Massachusetts Eye and Ear Infirmary, Harvard Medical School
    2015 RES Residency in Opthalmology, Louisiana State University Health Science Center (Shreveport)
    2011 FEL Postdoctoral Research Fellowship, Schepens Eye Research Institute, Harvard Medical School
    2004 PhD Qingdao University Medical College
    2004 MD Qingdao University
    2001 MS Qingdao University
    1998 BMED Qingdao University
  • Research

    Dr. Shaohui Liu has clinical and research interests in corneal and ocular surface diseases, the underlying mechanisms and new treatment modalities.

  • Professional Organizations
    American Academy of Ophthalmology
  • Board Certifications
    American Board of Ophthalmology - Ophthalmology
  • Clinical Interests

    Cornea & Ocular Surface Diseases, Dry Eye Syndrome, Partial and Full-Thickness Corneal Transplantation, Cataract Surgery, Laser Vision Correction

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