26478-Ems-McClung, Stephanie

Stephanie C. Ems-McClung, PhD

Associate Research Professor of Biochemistry & Molecular Biology

Phone 812-855-6785

Bloomington, IN 47405
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Stephanie C. Ems-McClung, PhD, graduated from the Department of Medical and Molecular Genetics with a Ph.D. at the Indiana School of Medicine in Indianapolis in 1998. She joined Dr. Claire Walczak’s lab in 2001 and was promoted to Associate Research Professor in 2022. Her research interests are in the biochemical mechanisms that regulate cytoskeletal dynamics and motor function as it relates to the processes of cell division. She applies diverse biochemical, biophysical, and structural approaches to answer fundamental questions about the regulation of motor protein function. She is also the Research Supervisor for Dr. Walczak’s laboratory and mentors both undergraduate and graduate students.

Key Publications

  1. Ems-McClung SC, Hainline SG, Devare J, Zong H, Cai S, Carnes SK, Shaw SL and Walczak CE. Aurora B inhibits MCAK activity through a phospho-conformational switch that reduces microtubule association.  Curr. Biol. 23:2491-2499.
  2. Ems-McClung SC, Emch M, Zhang S, Mahnoor S, Weaver LN, Walczak CE. 2020. RanGTP induces an effector gradient of XCTK2 and importin α/β for spindle microtubule cross-linking. J. Cell Bio. 219.

Titles & Appointments

  • Associate Research Professor of Biochemistry & Molecular Biology
  • Associate Research Professor of Biochemistry &amp
  • Molecular Biology
  • Research Supervisor
  • Education
    1998 PhD Indiana University
    1991 BS Indiana University
  • Research

    Spindle assembly, molecular motor activity and how they organize microtubules within the spindle, kinetochore function, and protein structure function relationships

  • Publications
    The far C-terminus of MCAK regulates its conformation and spindle pole focusing.
    Zong H; Carnes SK; Moe C; Walczak CE; Ems-McClung SC; Molecular biology of the cell 2016 Mar 3
  • Professional Organizations
    American Society for Cell Biology
    Biophysical Society

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