25526-Meyer, Jason
Faculty

Jason Meyer, PhD

Associate Professor of Medical & Molecular Genetics

Address
NB 400B
Department of Medical and Molecular Genetics

Indianapolis, IN 46202

Bio

Dr. Meyer received his bachelor’s degree from Colgate University and his doctoral degree from the University of Missouri. He completed his postdoctoral training at the University of Wisconsin and was later promoted to the rank of assistant scientist, where he developed the foundational ability to differentiate human pluripotent stem cells into retinal neurons. He is currently an Associate Professor of Medical and Molecular Genetics at Indiana University School of Medicine, with adjunct appointments in Ophthalmology and the Stark Neurosciences Research Institute.  His research focuses upon the differentiation of retinal ganglion cells from human pluripotent stem cells, including the derivation of glaucoma models through iPS cell reprogramming as well as Crispr/Cas9 gene editing. Ongoing projects in his lab explore the use of these cells for studies of RGC development as well as mechanisms underlying glaucomatous neurodegeneration.

Key Publications

VanderWall KB, Huang KC, Pan Y, Lavekar SS, Fligor CM, Allsop AR, Lentsch KA, Dang P, Zhang C, Tseng HC, Cummins TR, Meyer JS (2020), Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived From Three-Dimensional Retinal Organoids, Stem Cell Reports, https://doi.org/10.1016/j.stemcr.2020.05.009

Artero-Castro A, Rodriguez-Jimenez FJ, Jendelova P, VanderWall KB, Meyer JS, Erceg S (2020), Glaucoma as a Neurodegenerative Disease Caused By Intrinsic Vulnerability Factors, Prog Neurobiol, doi: 10.1016/j.pneurobio.2020.101817

Wang Q, Zhuang P, Huang H, Li L, Liu L, Webber HC, Dalal R, Siew L, Fligor CM, Chang KC, Nahmou M, Kremerman A, Sun Y, Meyer JS, Goldberg JL, Hu Y (2020), Mouse γ-Synuclein Promoter-Mediated Gene Expression and Editing in Mammalian Retinal Ganglion Cells, J Neurosci, 40(20):3896-3914.

Fligor CM, Huang KC, Lavekar SS, VanderWall KB, and Meyer JS (2020), Differentiation of Retinal Organoids from Human Pluripotent Stem Cells, Methods in Cell Biology, in press.

Ohlemacher SK, Langer KB, Fligor CM, Feder EM, Edler MC, and Meyer JS (2019), Advances in the Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells, Adv Exp Med Biol, 1186:121-140.

Hamilton J, Brustovetsky T, Sridhar A, Pan Y, Cummins TR, Meyer JS, and Brustovetsky N (2019), Energy Metabolism and Mitochondrial Superoxide Anion Production in Pre-Symptomatic Striatal Neurons Derived from Human Induced Pluripotent Stem Cells Expressing Mutant Huntingtin, Molecular Neurobiology, https://doi.org/10.1007/sl12035-019-01734-2.

VanderWall KB, Vij R, Ohlemacher SK, Sridhar A, Feder EM, Edler MC, Baucum AJ, Cummins TR, and Meyer JS (2019), Astrocytes Regulate the Development and Maturation of Retinal Ganglion Cells Derived from Human Pluripotent Stem Cells, Stem Cell Reports, 12(2):201-12.

Sridhar A, Langer KB, Fligor CM, Steinhart M, Miller CA, Ho-A-Lim K, Ohlemacher SK, and Meyer JS (2018), Human Pluripotent Stem Cells as In Vitro Models of Retinal Development and Disease, within Regenerative Medicine and Stem Cell Therapy for the Eye, ed. Ballios and Young, Springer Nature, pp. 17-49.

Fligor CM, Langer KB, Sridhar A, Ren Y, Shields PK, Edler MC, Ohlemacher SK, Sluch VM, Zack DJ, Zhang C, Suter DM, and Meyer JS (2018), Three-Dimensional Retinal Organoids Facilitate the Investigation of Retinal Ganglion Cell Development, Organization, and Neurite Outgrowth from Human Pluripotent Stem Cells, Scientific Reports, 8(1):14520.

Langer KB, Ohlemacher SK, Phillips MJ, Fligor CM, Jiang P, Gamm DM, and Meyer JS (2018), Retinal Ganglion Cell Diversity and Subtype Specification from Human Pluripotent Stem Cells, Stem Cell Reports, 10(4):1282-93.

Ohlemacher SK, Sridhar A, Xiao Y, Hochstetler A, Sarfarazi M, Cummins TR, and Meyer JS (2016), Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Facilitates Analysis of Glaucomatous Neurodegeneration, Stem Cells, 34(6):1553-62.

Sridhar A, Ohlemacher SK, Langer KB, and Meyer JS (2016), Robust Differentiation of mRNA-Reprogrammed Human Induced Pluripotent Stem Cells to a Retinal Lineage, Stem Cells Trans Med, 5(4):417-426.

Cooke JA and Meyer JS (2015), Human Pluripotent Stem Cell-Derived Retinal Ganglion Cells: Applications for the Study and Treatment of Optic Neuropathies, Curr Ophth Reports 3(3):200-206.

Ohlemacher SK, Iglesias CL, Sridhar A, and Meyer JS (2015), Generation of Highly Enriched Populations of Optic Vesicle-Like Retinal Cells from Human Pluripotent Stem Cells, Curr Prot Stem Cell Biol, 32:1H.8.1-1H.8.20.

Capowski EE, Simonett JM, Clark EM, Wright LS, Howden SE, Wallace KA, Petelinsek AM, Pinilla I, Phillips MJ, Meyer JS, Schneider BL, Thomson JA, and Gamm DM (2014), Loss of MITF expression during human embryonic stem cell differentiation disrupts retinal pigment epithelium development and optic vesicle cell proliferation, Hum Mol Gen 23(23):6332-44.

Zhong X, Gutierrez C, Xue T, Hampton C, Vergara MN, Cao LH, Peters A, Park TS, Zambidis ET, Meyer JS, Gamm DM, Yau KW, and Canto-Soler MV (2014), Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs, Nature Comm 5:4047.

Cassidy L, Choi M, Meyer J, Chang R, and Seigel GM (2013), Immunoreactivity of pluripotent markers SSEA-5 and L1CAM in human tumors, teratomas, and induced pluripotent stem cells, J Biomarkers, Article ID 960862, doi:10.1155/2013/960862.

Sridhar A, Steward MM, and Meyer JS (2013), Non-Xenogeneic Growth and Retinal Differentiation of Human Induced Pluripotent Stem Cells, Stem Cells Translational Medicine, 2(4):255-64.

Steward MM, Sridhar A, and Meyer JS (2013), Neural Regeneration, Curr Top Microbiol Immunol, 367:163-91.

Meyer JS, Howden S, Wallace KA, Verhoeven A, Wright LS, Capowski EE, Pinilla I, Martin JM, Stewart R, Pattnaik B, Thomson JA, and Gamm DM (2011), Optic Vesicle Structures Derived from Human Pluripotent Stem Cells Facilitate a Customized Approach to Retinal Disease Treatment, Stem Cells, 29(8):1206-18.

Gamm DM and Meyer JS (2010), Directed Differentiation of Human Induced Pluripotent Stem Cells: A Retina Perspective, Regen Med, 5(3):315-7.

Meyer JS, Shearer RL, Capowski E, Wright LS, Wallace KA, McMillan EL, Zhang SC, and Gamm DM (2009), Modeling Early Retinal Development with Human Embryonic and Induced Pluripotent Stem Cells, Proc Natl Acad Sci,106(39): 16698-703.

Meyer JS, Tullis GT, Pierret CK, and Kirk MD (2009), Detection of Calcium Transients in Embryonic Stem Cells and Their Differentiated Progeny, Cell Mol Neurobiol, Cell Mol Neurobiol, 29(8):1191-203.

Gamm D, Wright LS, Capowski EE, Shearer RL, Meyer JS, Kim HJ, Schneider B, Melvan JN, and Svendsen CN (2008), Regulation of Prenatal Human Retinal Neurosphere Growth and Cell Fate Potential by Retinal Pigment Epithelium and Mash1, Stem Cells 26(12): 3182-93.

Zhang ZJ, Meyer JS, and Zhang SC (2007), hES differentiation: Neural cell lineages, within Human Embryonic Stem Cells, Ed. by J. Masters, B. Palsson, and J. Thomson.

Meyer JS, Katz ML, Maruniak JA, and Kirk MD (2006), Embryonic stem cell derived neural precursors incorporate into the degenerating retina and enhance survival of host photoreceptors, Stem Cells 24(2): 274-283.

Meyer JS, Katz ML, and Kirk MD (2005), Stem Cells for Retinal Degenerative Disorders, Ann NY Acad Sci 1049:135-145.

Meyer JS, Katz ML, Maruniak JA, and Kirk MD (2004), Neural differenation of mouse embryonic stem cells in vitro and after transplantation into eyes of mutant mice with rapid retinal degeneration, Brain Res 1014(1):131-144.

Kirk MD, Meyer JS, Miller MW, and Govind CK (2001), Dichotomy in Phasic-Tonic Neuromuscular Structure of Crayfish Inhibitory Axons, J Comp Neurol 435: 283-90.

Titles & Appointments

  • Associate Professor of Medical & Molecular Genetics
  • Adjunct Associate Professor of Ophthalmology
  • Education
    2004 PhD University of Missouri
    1998 BA Colgate University
  • Research

    Induced pluripotent stem (iPS) cells are derived through the genetic reprogramming of somatic cells to yield a population of stem cells capable of giving rise to all cell types of the body. As such, they can be utilized to study some of the earliest events underlying the generationof specific cell types of the nervous system. Current research in the lab focuses upon the differentiation of iPS cells into retinal neurons, with important implications for the study of blinding neurodegenerative diseases.  Through the derivation of iPS cells from the somatic cells of patients with known genetic mutations underlying neurodegenerative diseases, it is possible to study the onset and progression of these diseases in the particular cell types affected by the disorder. Such an approach also allows for the development of personalized medicine approaches to treating diseases, as well as pharmacological screening with the goal of identifying novel compounds capable of treating these diseases.

  • Professional Organizations
    Association for Research in Vision and Ophthalmology
    International Society for Eye Research
    International Society for Stem Cell Research (ISSCR)
    Society for Neuroscience
  • Awards
    Org: IUPUI Graduate Mentoring Center
    Desc: Outstanding Graduate and Professional Student Mentoring
    Scope: Campus
    Date: 2018-04-01
    Org: Indiana University
    Desc: Trustees Teaching Award
    Scope: University
    Date: 2018-04-01
    Org: Association for Research in Vision and Ophthalmology (ARVO)
    Desc: ARVO-AFER/Merck Innovative Ophthalmology Award
    Scope: International
    Date: 2011-05-01

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