Jason Meyer, PhD
A. Donald Merritt Professor of Medical & Molecular Genetics
Adjunct Professor of Pharmacology & Toxicology
Adjunct Professor of Ophthalmology
- Phone
- (317) 274-1040
- Address
-
NB 400B
Department of Medical and Molecular Genetics
Indianapolis, IN 46202 - PubMed:
-
Bio
Dr. Meyer received his bachelor’s degree from Colgate University and his doctoral degree from the University of Missouri. He completed his postdoctoral training at the University of Wisconsin and was later promoted to the rank of assistant scientist, where he developed the foundational ability to differentiate human pluripotent stem cells into retinal neurons. He is currently an Associate Professor of Medical and Molecular Genetics at Indiana University School of Medicine and a Primary Investiagator at the Stark Neurosciences Research Institute, with adjunct appointments in Pharmacology and Toxicology, as well as Ophthalmology. His research focuses upon the use of human pluripotent stem cells as in vitro model of neurodegeneration, including iPS cell reprogramming as well as Crispr/Cas9 gene editing. Ongoing projects in his lab explore the use of these cells for studies of neurodegeneration associated with either glaucoma or Alzheimer's disease, as well as neuron/glia interactions and how glial cells such as astrocytes and microglia mediate neurodegeneration of neurons.
Key Publications
Harkin J, Peña KH, Gomes C, Hernandez M, Lavekar SS, So K, Lentsch K, Feder EM, Morrow S, Huang KC, Tutrow KD, Morris A, Zhang C, Meyer JS (2024), A highly reproducible and efficient method for retinal organoid differentiation from human pluripotent stem cells, Proceedings of the National Academy of Sciences, 121(25):e2317285121.
Screven LA, Pantazis CB, Andersh KM, Hong S, Vitale D, Lara E, Ku RY, Heutink P, Meyer JS, Faber K, Nho K, Saykin AJ, Foroud TM, Nalls MA, Blauwendraat C, Singleton A, Narayan PS (2024), Harnessing diversity to study Alzheimer's disease: A new iPSC resource from the NIH CARD and ADNI, Neuron, 112(5):694-697.
Lavekar SS, Harkin J, Hernandez M, Gomes C, Patil S, Huang KC, Puntambekar SS, Lamb BT, Meyer JS (2023), Development of a three-dimensional organoid model to explore early retinal phenotypes associated with Alzheimer's disease, Scientific Reports, 13(1):13827.
Gomes C*, VanderWall KB*, Pan Y, Lu X, Lavekar SS, Huang KC, Fligor CM, Harkin J, Zhang C, Cummins TR, Meyer JS (2022), Astrocytes modulate neurodegenerative phenotypes associated with glaucoma in OPTN(E50K) human stem cell-derived retinal ganglion cells, Stem Cell Reports, 17(7): 1636-1649.
Fligor CM, Lavekar SS, Harkin J, Shields PK, VanderWall KB, Huang KC, Gomes C, Meyer JS (2021), Extension of retinofugal projections in an assembled model of human pluripotent stem cell-derived organoids, Stem Cell Reports, 16(9): 2228-2241.
VanderWall KB, Huang KC, Pan Y, Lavekar SS, Fligor CM, Allsop AR, Lentsch KA, Dang P, Zhang C, Tseng HC, Cummins TR, Meyer JS (2020), Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived From Three-Dimensional Retinal Organoids, Stem Cell Reports, 15(1):52-66.
VanderWall KB, Vij R, Ohlemacher SK, Sridhar A, Feder EM, Edler MC, Baucum AJ, Cummins TR, and Meyer JS (2019), Astrocytes Regulate the Development and Maturation of Retinal Ganglion Cells Derived from Human Pluripotent Stem Cells, Stem Cell Reports, 12(2):201-12.
Fligor CM, Langer KB, Sridhar A, Ren Y, Shields PK, Edler MC, Ohlemacher SK, Sluch VM, Zack DJ, Zhang C, Suter DM, and Meyer JS (2018), Three-Dimensional Retinal Organoids Facilitate the Investigation of Retinal Ganglion Cell Development, Organization, and Neurite Outgrowth from Human Pluripotent Stem Cells, Scientific Reports, 8(1):14520.
Langer KB, Ohlemacher SK, Phillips MJ, Fligor CM, Jiang P, Gamm DM, and Meyer JS (2018), Retinal Ganglion Cell Diversity and Subtype Specification from Human Pluripotent Stem Cells, Stem Cell Reports, 10(4):1282-93.
Ohlemacher SK, Sridhar A, Xiao Y, Hochstetler A, Sarfarazi M, Cummins TR, and Meyer JS (2016), Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Facilitates Analysis of Glaucomatous Neurodegeneration, Stem Cells, 34(6):1553-62.
Zhong X, Gutierrez C, Xue T, Hampton C, Vergara MN, Cao LH, Peters A, Park TS, Zambidis ET, Meyer JS, Gamm DM, Yau KW, and Canto-Soler MV (2014), Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs, Nature Comm 5:4047.
Meyer JS, Howden S, Wallace KA, Verhoeven A, Wright LS, Capowski EE, Pinilla I, Martin JM, Stewart R, Pattnaik B, Thomson JA, and Gamm DM (2011), Optic Vesicle Structures Derived from Human Pluripotent Stem Cells Facilitate a Customized Approach to Retinal Disease Treatment, Stem Cells, 29(8):1206-18.
Meyer JS, Shearer RL, Capowski E, Wright LS, Wallace KA, McMillan EL, Zhang SC, and Gamm DM (2009), Modeling Early Retinal Development with Human Embryonic and Induced Pluripotent Stem Cells, Proc Natl Acad Sci,106(39): 16698-703.
| Year | Degree | Institution |
|---|---|---|
| 2004 | PhD | University of Missouri |
| 1998 | BA | Colgate University |
Induced pluripotent stem (iPS) cells are derived through the genetic reprogramming of somatic cells to yield a population of stem cells capable of giving rise to all cell types of the body. As such, they can be utilized to study some of the earliest events underlying the generationof specific cell types of the nervous system. Current research in the lab focuses upon the differentiation of iPS cells into neurons and glia, with important implications for the study of neurodegenerative diseases. Through the derivation of iPS cells from the somatic cells of patients with known genetic mutations underlying neurodegenerative diseases, it is possible to study the onset and progression of these diseases in the particular cell types affected by the disorder. Such an approach also allows for the development of personalized medicine approaches to treating diseases, as well as pharmacological screening with the goal of identifying novel compounds capable of treating these diseases.
Harkin J; Peña KH; Gomes C; Hernandez M; Lavekar SS; So K; Lentsch K; Feder EM; Morrow S; Huang KC; Tutrow KD; Morris A; Zhang C; Meyer JS; Proceedings of the National Academy of Sciences of the United States of America 2024 Jun 13
Screven LA; Pantazis CB; Andersh KM; Hong S; Vitale D; Lara E; Ku RY; Heutink P; Meyer J; Faber K; Nho K; Saykin AJ; Foroud TM; Nalls MA; Blauwendraat C; Singleton A; Narayan PS; Neuron 2024 Feb 21
Lavekar SS; Harkin J; Hernandez M; Gomes C; Patil S; Huang KC; Puntambekar SS; Lamb BT; Meyer JS; Scientific reports 2023 Aug 24
Gomes C; VanderWall KB; Pan Y; Lu X; Lavekar SS; Huang KC; Fligor CM; Harkin J; Zhang C; Cummins TR; Meyer JS; Stem cell reports 2022 Jun 16
Fligor CM; Lavekar SS; Harkin J; Shields PK; VanderWall KB; Huang KC; Gomes C; Meyer JS; Stem cell reports 2021 Jun 10
VanderWall KB; Lu B; Alfaro JS; Allsop AR; Carr AS; Wang S; Meyer JS; Scientific reports 2020 Oct 15
Fligor CM; Huang KC; Lavekar SS; VanderWall KB; Meyer JS; Methods in cell biology 2020 Mar 11
VanderWall KB; Huang KC; Pan Y; Lavekar SS; Fligor CM; Allsop AR; Lentsch KA; Dang P; Zhang C; Tseng HC; Cummins TR; Meyer JS; Stem cell reports 2020 Jun 11
Wang Q; Zhuang P; Huang H; Li L; Liu L; Webber HC; Dalal R; Siew L; Fligor CM; Chang KC; Nahmou M; Kreymerman A; Sun Y; Meyer JS; Goldberg JL; Hu Y; The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Apr 16
VanderWall KB; Vij R; Ohlemacher SK; Sridhar A; Fligor CM; Feder EM; Edler MC; Baucum AJ 2nd; Cummins TR; Meyer JS; Stem cell reports 2019 Jan 10
Hamilton J; Brustovetsky T; Sridhar A; Pan Y; Cummins TR; Meyer JS; Brustovetsky N; Molecular neurobiology 2019 Aug 21
Ohlemacher SK; Langer KB; Fligor CM; Feder EM; Edler MC; Meyer JS; Advances in experimental medicine and biology 2019
Fligor CM; Langer KB; Sridhar A; Ren Y; Shields PK; Edler MC; Ohlemacher SK; Sluch VM; Zack DJ; Zhang C; Suter DM; Meyer JS; Scientific reports 2018 Sep 28
Langer KB; Ohlemacher SK; Phillips MJ; Fligor CM; Jiang P; Gamm DM; Meyer JS; Stem cell reports 2018 Mar 22
Ohlemacher SK; Sridhar A; Xiao Y; Hochstetler AE; Sarfarazi M; Cummins TR; Meyer JS; Stem cells (Dayton, Ohio) 2016 Mar 21
Sridhar A; Ohlemacher SK; Langer KB; Meyer JS; Stem cells translational medicine 2016 Mar 1
Weick JP; Meyer JS; Ladewig J; Guo W; Liu Y; Stem cells international 2016 Aug 24
Ohlemacher SK; Iglesias CL; Sridhar A; Gamm DM; Meyer JS; Current protocols in stem cell biology 2015 Feb 2
Cooke JA; Meyer JS; Current ophthalmology reports 2015 Aug 7
Zhong X; Gutierrez C; Xue T; Hampton C; Vergara MN; Cao LH; Peters A; Park TS; Zambidis ET; Meyer JS; Gamm DM; Yau KW; Canto-Soler MV; Nature communications 2014 Jun 10
Capowski EE; Simonett JM; Clark EM; Wright LS; Howden SE; Wallace KA; Petelinsek AM; Pinilla I; Phillips MJ; Meyer JS; Schneider BL; Thomson JA; Gamm DM; Human molecular genetics 2014 Jul 9
Sridhar A; Steward MM; Meyer JS; Stem cells translational medicine 2013 Mar 19
Steward MM; Sridhar A; Meyer JS; Current topics in microbiology and immunology 2013
Meyer JS; Howden SE; Wallace KA; Verhoeven AD; Wright LS; Capowski EE; Pinilla I; Martin JM; Tian S; Stewart R; Pattnaik B; Thomson JA; Gamm DM; Stem cells (Dayton, Ohio) 2011 Aug
Meyer JS; Tullis G; Pierret C; Spears KM; Morrison JA; Kirk MD; Cellular and molecular neurobiology 2009 Dec
Meyer JS; Shearer RL; Capowski EE; Wright LS; Wallace KA; McMillan EL; Zhang SC; Gamm DM; Proceedings of the National Academy of Sciences of the United States of America 2009 Aug 25
Gamm DM; Wright LS; Capowski EE; Shearer RL; Meyer JS; Kim HJ; Schneider BL; Melvan JN; Svendsen CN; Stem cells (Dayton, Ohio) 2008 Sep 18
Meyer JS; Katz ML; Kirk MD; Annals of the New York Academy of Sciences 2005 May
Meyer JS; Katz ML; Maruniak JA; Kirk MD; Stem cells (Dayton, Ohio) 2005 Aug 25
Meyer JS; Katz ML; Maruniak JA; Kirk MD; Brain research 2004 Jul 16
Kirk MD; Meyer JS; Miller MW; Govind CK; The Journal of comparative neurology 2001 Jul 2
Desc: Outstanding Postdoctoral Mentor Award
Scope: University
Date: 2020-11-01
Desc: Outstanding Graduate and Professional Student Mentoring
Scope: Campus
Date: 2018-04-01
Desc: Trustees Teaching Award
Scope: University
Date: 2018-04-01
Desc: ARVO-AFER/Merck Innovative Ophthalmology Award
Scope: International
Date: 2011-05-01