22816-Ware, Stephanie

Stephanie Ware, MD, PhD

Professor of Pediatrics

Herman B Wells Center for Pediatric Research
1044 W. Walnut St., R4-227

Indianapolis, IN 46202


Stephanie M. Ware, MD, PhD, is a Professor of Pediatrics and Medical and Molecular Genetics, Vice Chair of Clinical Affairs in Medical and Molecular Genetics, and Program Leader in Cardiovascular Genetics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine.  Dr. Ware graduated Summa cum laude with highest honors in Zoology from Butler University. She earned her MD and PhD degrees at the University of Cincinnati College of Medicine where she was elected to Alpha Omega Alpha Honor Society. She completed her pediatric residency and clinical genetics fellowship at Baylor College of Medicine in Houston, Texas.  Dr. Ware’s research interests include the genetic and developmental basis of disorders of cardiac structure and function. Her research laboratory has made significant contributions in the areas of congenital heart defects and cardiomyopathy. Dr. Ware is a member of the American Heart Association, the American Society for Human Genetics, the Society for Pediatric Research, the American Society for Clinical Investigation, and is Faculty of the American College of Medical Genetics and Genomics. She has received a number of scholarly awards for her research. Dr. WAre has a longstanding track record of independent funding from the NIH and multiple foundations for basic and translational research. In addition, she participates in multi-site initiatives including serving as PI of the Genetic Coordinating Center for the NHLBI funded study to identify genotype-phenotype correlations in pediatric cardiomyopathy and serving as PI for the Cytogenomics of Cardiovascular Malformations Consortium. The long term goals of the clinical, translational, and basic research approaches are to identify causes and potential management of disorders of cardiac structure and function.  Clinically, she evaluates and manages patients with genetic disorders and has specific expertise in cardiomyopathy and syndromes with cardiovascular disease. She was recruited to IUSM in March, 2014 to initiate a cardiovascular genetics program that would encompass clinical cardiovascular genetics services and basic and translational cardiovascular genetics research. 

Titles & Appointments

  • Professor of Pediatrics
  • Professor of Medical & Molecular Genetics
  • Education
    2004 FEL Baylor College of Medicine
    1997 MD University of Cincinnati
    1995 PhD University of Cincinnati
    1989 BS Butler University
  • Research

    Dr. Ware has research programs that focus on the genetic and developmental basis of pediatric heart disease. The two main areas of interest are disorders of cardiac function (cardiomyopathies) and structure (congenital heart disease). The laboratory utilizes animal models to investigate the developmental mechanisms and pathobiology of these disorders. The lab is specifically interested in developmental pathways important for normal left-right patterning and cardiac looping during embryogenesis. Translational research on congenital heart defects aims to investigate and identify novel genes underlying cardiovascular malformations using genome-wide analyses. High priority candidate genes identified by this approach are validated using high throughput screens in Xenopus, with novel candidates being further evaluated in mouse models of disease. Dr. Ware also coordinates the Cytogenomics of Cardiovascular Malformations Consortium, a highly collaborative alliance of outstanding academic pediatric cardiovascular genetic centers that have developed a clinical cytogenetic registry with deep cardiac phenotyping. Research efforts in cardiomyopathy are focused on identifying novel causes of pediatric cardiomyopathy, delineating genetic modifiers utilizing genomic technologies for functional annotation and validation of genetic variants.

  • Professional Organizations
    American Board of Medical Genetics
    American College of Medical Genetics and Genomics (ACMG)
    American Heart Association
    American Society for Clinical Investigation
    American Society of Human Genetics (ASHG)
    Society for Pediatric Research
    Society of Developmental Biology/FASEB
    Society of Genetics and Birth Defects
  • Board Certifications
    American Board of Medical Genetics and Genomics
    American Board of Pediatrics - Pediatrics
  • Clinical Interests

    As the Program Leader in Cardiovascular Genetics, Dr. Ware coordinates clinical genetic services for patients with cardiomyopathy, genetic syndromic conditions, aortopathy and vascular disorders, and inherited arrhythmias.


  • Awards
    Org: Aubrey Rose Foundation
    Desc: Doctor of the Year Award
    Scope: National
    Org: American Society for Clinical Investigation
    Desc: Elected Member
    Scope: National
    Org: American Heart Association
    Desc: Established Investigator Award
    Scope: National

Looking for patient care?

To schedule an appointment with a faculty member physician of IU School of Medicine, contact Indiana University Health at 888-484-3258 or use the physician finder by clicking the button below.

Find a doctor