22419-Kloepfer, Kirsten
Faculty

Kirsten M. Kloepfer, MD

Assistant Professor of Pediatrics

Bio

Dr. Kloepfer is an assistant professor of pediatrics at Indiana University School of Medicine. She is a graduate of St. George’s University. Dr. Kloepfer completed her pediatric residency at University of Arkansas for Medical Sciences and an allergy and immunology fellowship at the University of Wisconsin.  Dr. Kloepfer holds membership in numerous national professional societies including the American Academy of Allergy, Asthma and Immunology (AAAAI), the American Thoracic Society (ATS), and the Indiana Allergy Society. Her Research focuses on the development of the upper airway microbiome and its association with local inflammatory cytokine expression and airway obstruction.

 

Titles & Appointments

  • Assistant Professor of Pediatrics
  • Education
    2013 FEL University of Wisconsin
    2013 FEL University of Wisconsin
    2012 MS University of Wisconsin (Madison)
    2012 MS University of Wisconsin-Madison
    2012 MS University of Wisconsin-Madison
    2009 RES University of Arkansas for Medical Sciences
    2009 RES University of Arkansas for Medical Sciences
    2006 MD St. George's University
    2006 MD St. George's University
    2006 MD St. George's University
    1998 BS Texas A & M University
    1998 BS Texas A&M University
    1998 BS Texas A&M University
  • Research

    While investigating the association between pathogens and asthma exacerbations, Dr. Kloepfer became interested in the influence of airway bacteria on airway development. Culture detection of S. pneumoniae, H. influenzae or M. catarrhalis in infancy is associated with early wheeze and asthma, as well as increased expression of pro-inflammatory cytokines IL-4 and IL-13. Furthermore, Dr. Kloepfer’s preliminary data demonstrates that decreased bacterial diversity in the airway at three months of age is associated with increased expression of IL-33 and IL-5, and wheeze by six months of age, suggesting that decreased bacterial diversity contributes to airway reactivity during early airway development. While an association has been established between cultured bacteria and the expression of pro-inflammatory cytokines; 16S rRNA sequencing that detects more bacteria than older culture techniques (97% vs. 5%), has not been utilized to investigate if decreased diversity of airway bacteria during infancy is linked with 1) an increase in pro-inflammatory cytokine expression and 2) airway obstruction. Because the prevalence of asthma continues to increase every year (currently 10% of the population), the etiology of asthma development needs further delineation, particularly in the developing airway prior to an asthma diagnosis. Therefore, to address the above questions, Dr. Kloepfer is currently investigating if airway dysbiosis is associated with an increase in pro-inflammatory cytokine expression and airway obstruction characterized by a decrease pulmonary function values and early episodes of wheeze.

  • Publications
    Community-acquired rhinovirus infection is associated with changes in the airway microbiome.
    Kloepfer KM; Sarsani VK; Poroyko V; Lee WM; Pappas TE; Kang T; Grindle KA; Bochkov YA; Janga SC; Lemanske RF Jr; Gern JE; The Journal of allergy and clinical immunology 2017 Mar 19
    Variations in pollen counts between Indianapolis, IN, and Dayton, OH, in spring 2013 and 2014.
    Vitalpur G; Padgett S; Kloepfer KM; Slaven J; Leickly FE; Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2016 Jul 25
    Multisystem reactions during egg oral food challenges may be associated with less severe reactions on initial presentation.
    Vitalpur G; Esquivel A; Kloepfer KM; Slaven JE; Leickly FE; Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2016 Apr 28
    Detection of pathogenic bacteria during rhinovirus infection is associated with increased respiratory symptoms and asthma exacerbations.
    Kloepfer KM; Lee WM; Pappas TE; Kang TJ; Vrtis RF; Evans MD; Gangnon RE; Bochkov YA; Jackson DJ; Lemanske RF Jr; Gern JE; The Journal of allergy and clinical immunology 2014 Apr 1
    Increased H1N1 infection rate in children with asthma.
    Kloepfer KM; Olenec JP; Lee WM; Liu G; Vrtis RF; Roberg KA; Evans MD; Gangnon RE; Lemanske RF Jr; Gern JE; American journal of respiratory and critical care medicine 2012 Feb 23
    Effects of montelukast on patients with asthma after experimental inoculation with human rhinovirus 16.
    Kloepfer KM; DeMore JP; Vrtis RF; Swenson CA; Gaworski KL; Bork JA; Evans MD; Gern JE; Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2011 Jan 13
  • Professional Organizations
    American Academy of Allergy, Asthma, and Immunology
    American Academy of Pediatrics
    American Thoracic Society
    European Academy of Allergy and Clinical Immunology
    Indiana Allergy Society
  • Board Certifications
    American Board of Allergy and Immunology - Allergy and Immunology
    American Board of Pediatrics - Pediatrics
  • Clinical Interests

    As a member of the high risk asthma team, I am interested in identifying environmental factors that may prevent their asthma from being well controlled, and working with families to help change these environmental exposures. I also enjoy caring for children with hereditary angioedema, seasonal allergies and food allergies.

  • Awards
    Org: National Institute of Health
    Desc: National Institute of Health Loan Repayment Program (LRP) Award
    Scope: National
    Date: 2019-01-01
    Org: National Institute of Health
    Desc: National Institute of Health Loan Repayment Program (LRP) Award
    Scope: National
    Date: 2018-01-01
    Org: National Institute of Allergy and Infectious Disease
    Desc: K23 Career Development Award
    Scope: National
    Date: 2017-11-01
    Org:
    Desc: Showalter Trust Award
    Scope: National
    Date: 2017-07-01
    Org: American Academy of Allergy, Asthma and Immunology Foundation
    Desc: Faculty Development Award
    Scope: National
    Date: 2017-02-01
    Org: National Institute of Health
    Desc: National Institute of Health Loan Repayment Program (LRP) Award
    Scope: National
    Date: 2017-01-01
    Org: National Institute of Health
    Desc: National Institute of Health Loan Repayment Program (LRP) Award
    Scope: National
    Date: 2016-01-01
    Org: National Institute of Health
    Desc: National Institute of Health Loan Repayment Program (LRP) Award
    Scope: National
    Date: 2015-01-01
    Org: Ninth Annual Respiratory Disease Young Investigators’ Forum
    Desc: Third Place Clinical Research
    Scope: National
    Date: 2013-10-01
    Org: National Institute of Health
    Desc: National Institute of Health Loan Repayment Program (LRP) Award
    Scope: National
    Date: 2013-01-01
    Org: National Institute of Health
    Desc: National Institute of Health Loan Repayment Program (LRP) Award
    Scope: National
    Date: 2012-01-01
    Org: American Academy of Allergy, Asthma and Immunology
    Desc: Fellow-in-training Interest Section Award for Environmental and Occupational Respiratory Diseases
    Scope: National
    Date: 2011-03-01
    Org: National Institute of Health
    Desc: National Institute of Health Loan Repayment Program (LRP) Award
    Scope: National
    Date: 2011-01-01
    Org: Southern Society for Pediatric Research
    Desc: Young Investigator of the Year
    Scope: Regional
    Date: 2007-02-01

Looking for patient care?

To schedule an appointment with a faculty member physician of IU School of Medicine, contact Indiana University Health at 888-484-3258 or use the physician finder by clicking the button below.

Find a doctor