22257-McKinley, Todd

Todd O. McKinley, MD

Professor of Orthopaedic Surgery

MPC1 #535
Indianapolis, IN
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Dr. McKinley attended medical school with a Bachelor of Science in Aeronaut/Aerospace Engineering Technology from the University of Minnesota. He completed a two-week rotation in orthopaedic surgery during his senior year of medical school at the University of Minnesota, and the experience rooted him in the subspecialty.

Following his residency, he did two orthopaedic fellowships – the first was a research fellowship, the second a trauma fellowship.  He was faculty at the University of Iowa for 13 years.

A job offer years later brought him to Indiana University School of Medicine, where he now serves as a professor of orthopaedic surgery.

Helping mold young medical minds is a rewarding venture, especially seeing how residents and fellows mature emotionally and academically over time. He hopes his students learn from him how important it is to get to know their patients, to understand them on all levels, and not see them as simply clinical cases.

McKinley's clinical interests include polytrauma, pelvic and acetabular surgery, infection and young-adult hip deformity. He has performed more than 400 periacetabular osteotomies.

He has been the principal investigator on six peer-reviewed grants, including three major grants from the Centers for Disease Control and Prevention, National Institutes of Health and the Department of Defense. He was appointed chairman of the Orthopaedic Trauma Association Research Committee and is a member of the Orthopaedic Research Society.

Key Publications

Computational Immunologic Orchestration Discriminates Between Multiply Injured Patients Who are Tolerant or Sensitive to Hemorrhage.    McKinley TO, Gaski GE, Zamora R, Namas RA, Shen L, Sun Q, Billiar TR and Vodovotz Y.   Journal of Trauma and Acute Care Surgery.  in press 2020.

Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis.   Coleman MC, Goetz JE, Brouillette MJ, Seol D, Willey MC, Petersen EB, Anderson HD, Hendrickson NR, Compton J, Khorsand B, Morris AS, Salem AK, Fredericks DC, McKinley TO, Martin JA.Coleman MC, et al. Among authors: mckinley to. Sci Transl Med. 2018 Feb 7;10(427):

Blood purification by nonselective hemoadsorption prevents death after traumatic brain injury and hemorrhagic shock in rats.
McKinley TO, Lei Z, Kalbas Y, White FA, Shi Z, Wu F, Xu ZC, Rodgers RB.McKinley TO, et al. J Trauma Acute Care Surg. 2018 Dec;85(6):1063-1071.
Shock volume: Patient-specific cumulative hypoperfusion predicts organ dysfunction in a prospective cohort of multiply injured patients.
McKinley TO, McCarroll T, Metzger C, Zarzaur BL, Savage SA, Bell TM, Gaski GE.McKinley TO, et al. J Trauma Acute Care Surg. 2018 Jul;85(1S Suppl 2):S84-S91

Titles & Appointments

  • Professor of Orthopaedic Surgery
  • Adjunct Professor of Anatomy, Cell Biology & Physiology
  • Education
    1992 MD University of Minnesota
    1986 BS University of Minnesota
  • Research

    Dr. McKinley is an orthopaedic surgeon that has a lineage of trauma research with experiments that have investigated foundational response of cartilage to injury.  In addition, he has been involved in developing new experimental treatments for acutely damaged cartilage.  These investigations explore the core of mechanobiology in osteochondral tissue and have been conducted at the cellular, tissue, small animal and pre-clinical levels.

    He is a leader in polytrauma research in Orthopaedics.  His research focuses on precision approaches to the response to major injury and shock.  He is funded by the Department of Defense for these investigations

  • Board Certifications
    American Board of Orthopaedic Surgery - Orthopaedic Surgery
  • Clinical Interests

    multiply injured patients

    pelvic surgery

    adult hip dysplasia

Research Labs

Faculty research at IU School of Medicine is transforming health. Details about the medical research being conducted in faculty labs throughout IU School of Medicine are available in the Research section of this site.

Faculty Labs