21752-Prosperi, Jeni

Jeni Prosperi, PhD

Associate Professor of Biochemistry & Molecular Biology

1234 N Notre Dame Ave
A134 Harper Hall

South Bend, IN 46617
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  • Assistant Professor, Biochemistry and Molecular Biology, Indiana University School of Medicine 2012- Present
  • Adjunct Assistant Professor, Biological Sciences, University of Notre Dame 2013-Present
  • Post-doctoral Fellow at University of Chicago (K. Goss Lab) 2007-2012
  • Post-doctoral Fellow at University of Cincinnati (K. Goss Lab) 2007
  • PhD Integrated Biomedical Science, The Ohio State University 2006
  • BA Microbiology, Miami University, Oxford, Ohio 2000

Key Publications

  • VanKlompenberg, M.K., Bedalov, C., Fernandez Soto, K., and Prosperi, J.R. (2015) APC selectively mediates response to chemotherapeutic agents in breast cancer. BMC Cancer, Jun 7;15:457. PMCID: PMC4458029.
  • Lesko, A.C., Goss, K.H., Yang, F., Schwertner, A., Hulur, I., Onel, K., and Prosperi, J.R. (2015). The APC tumor suppressor is required for epithelial cell polarization and three-dimensional morphogenesis. BBA - Molecular Cell Research (ELS) 1853(3), 711-723.
  • Lesko, A.C., Goss, K.H., and Prosperi, J.R. (2014). Exploiting APC Function as a Novel Cancer Therapy. Curr Drug Targets 15(1), 90-102.
  • Odenwald, M.A.*, Prosperi, J.R.*, and Goss, K.H. (2013) Localization of the APC tumor suppressor at cell protrusions is required for breast cancer cell migration and invasion. BMC Cancer, 13:12. PMCID: PMC3556124 *These authors contributed equally to this work.
  • Prosperi, J.R., and Goss, K.H. (2012) Wnt signaling in lactation. In: Lactation: Natural Processes, Physiological Responses and Role in Maternity, Nova Science Publishers. Eds: Lisa M. Reyes Cruz and Douglas C. Ortiz Gutierrez.
  • Prosperi, J.R., Khramtsova, G.F., Khramtosov, A.I., and Goss, K.H. (2011) Loss of APC promotes PyMT-mediated mammary tumorigenesis. PLoS ONE, 6(12):e29339.
  • Prosperi, J.R. and Goss, K.H. (2011) Wnt Pathway-independent Activities of the APC Tumor Suppressor. In: Tumor Suppressors, Ed: Susan D. Nguyen, Nova Science Publishers, pp. 105-132.
  • Prosperi, J.R., Lue, H.H., and Goss. K.H. (2011) Dysregulation of the Wnt Pathway in Solid Tumors. In: Targeting the Wnt Pathway in Cancer. Eds: Kathleen Goss and Michael Kahn, Springer, New York, pp. 81-128.
  • Prosperi, J.R., and Goss, K.H. (2010) A Wnt-ow of Opportunity: Targeting the Wnt/b-catenin Pathway in Breast Cancer. Curr Drug Targets, Sep;11(9):1074-88.
  • Prosperi, J.R.*, Becher, K.R.*, Willson, T.A., Collins, M.H., Witte, D.P., and Goss, K.H. (2009) The APC tumor suppressor is required for epithelial integrity in the mouse mammary gland. J. Cell Phys, Aug;220(2):319-31. *These authors contributed equally to this work.
  • Robertson, F.M., Mallery, S.R., Bergdall-Costell, V.K., Cheng, M, Pei, P, Prosperi, J.R., Ferrari, M. (2007) Cyclooxygenase-2 directly induces MCF-7 breast tumor cells to develop into exponentially growing, highly angiogenic and regionally invasive human ductal carcinoma xenografts. Anticancer Res. Mar-Apr; 27(2): 719-27.
  • Prosperi, J.R., and Robertson, F.M. (2006) Cyclooxygenase-2 Directly Regulates Gene Expression of P450 Cyp19 Aromatase Promoter Regions pII, pI.3, and pI.7, and Estradiol Production in Human Breast Tumor Cells. Prostaglandins Other Lipid Mediat, Oct;81(1-2):55-70.
  • Prosperi, J.R., Mallery, S.R, Kigerl, K.A., Erfurt, A.A., and Robertson, F.M. (2004) Invasive and Angiogenic Phenotype of MCF-7 Human Breast Tumor Cells Expressing Human Cyclooxygenase-2. Prostaglandins Other Lipid Mediat, Apr;73(3-4):249-64.

Titles & Appointments

  • Associate Professor of Biochemistry & Molecular Biology

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