Tao Lu

Tao Lu, PhD

Assistant Professor of Pharmacology & Toxicology

Bio

I have an extensive background in signaling transduction, molecular and cellular biology, biochemistry, genetics, and pharmacology with specific expertise in NF-kB signaling, post-translational modification, cancer epigenetics, and drug discovery. Born in a physician and medical professor’s family, I was fascinated by medical science from a very young age. I studied signaling transduction in cell death during my graduate study with Dr. Ronald L. Mellgren. My postdoctoral training was with the world renowned cancer biologist and geneticist Dr. George R. Stark, who famously contributed to the development of both Western Blot and Northern Blot techniques that are widely used by the scientists all over the world. Dr. Stark also discovered interferon/JAK/Stat pathway. I was an Assistant Professor at Lerner College of Medicine at Case Western Reserve University (CWRU) before I relocated to Indianapolis.   

Positions

 

2012-present 

Assistant Professor (tenure track), Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN

2012-present

Adjunct Assistant Professor, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN

2012-present

Adjunct Assistant Professor, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN

2009-2011

Assistant Professor  in Molecular Medicine, Lerner College of Medicine at Case Western Reserve University (CWRU), Cleveland, OH

2006-2011

Project Scientist, Department of Molecular Genetics, Cleveland Clinic, Cleveland, OH

2003-2011

Research Associate, Department of Molecular Genetics, Cleveland Clinic, Cleveland, OH

 

Honor

 

2018

Keynote Speaker, "Cancer-2018", International Conference on Cancer Research

2017

Faculty Member of the Year, Indiana University School of Medicine, Indianapolis, IN

2016

Trustees’ Teaching Award, Indiana University School of Medicine, Indianapolis, IN

2015

Honorary Keynote Speaker, The Larry Gentry Research Forum, University of Toledo School of Medicine, Toledo, OH

2015

Elwert Award in Medicine, Indiana University School of Medicine, Indianapolis, IN

2015

GlaxoSmithKline's Discovery Fast Track Challenge Nominee, Indiana University, Indianapolis, IN

2014

National Pew Scholar Nominee in Cancer Research, Indiana University, Indianapolis, IN

2014

Young Investigator Travel Award, International Cytokine and Interferon Society Conference 

2013

Fellow, Leadership in Academic Medicine Program (LAMP), Indiana University, Indianapolis, IN

2013

F1000 Prime for High Impact Publication,  twice

2012

Walther Scholar, Indiana University Walther Oncology Center, Indianapolis, IN

2009

ICS Young Investigator Award, Tri-Society [Society of Leukocyte Biology (SLB) & ICS & ISICR] Conference 

2008

Seymour and Vivian Milstein Young Investigator Award, International Society of Interferon & Cytokine Research (ISICR) & ICS Conference 

2007

Innovator Award, Cleveland Clinic, Cleveland, OH 

2007

Young Investigator Travel Award, International Cytokine Society (ICS) Conference 

2004

Young Investigator Travel Award, International Society of Interferon & Cytokine Research (ISICR) Conference 

2004

Innovator Award, Cleveland Clinic, Cleveland, OH

2000

Liberato J.A. DiDio Graduate Research Award, University of Toledo School of Medicine, Toledo, OH 

International Professional Activities

Reviewer           

(selected from over 20 journals): Molecular Cellular Biology (MCB), Proc Natl Acad Sci (PNAS), Oncogene, Cancer Research, FASEB J, Scientific Report, Cancer Letter, J Virology, European Journal of Cell Biology  (EJCB)

Member   

Advisory Board, International BIT Annual World Congress of Molecular and Cellular Biology

Reviewer           

Medical Research Council (MRC), England

Co-Chair           

2nd International Summit on Integrative Biology

Session Chair    

International Conference on Retroviruses and Novel Drugs

Reviewer           

Austrian Science Fund (FWF), Austrian Special Research Program (SFB)

Member             

Editorial Board, Journal of Clinical Pharmacology and Toxicology (JCPT)

Reviewer           

The Welcome Trust/DBT India Alliance, Biomedical Fellowship Program

Member             

Editorial Board, Journal of Pharmacology Research and Toxicology

Member              

Editorial Board, Clinical Cancer Drugs

Member              

Editorial Board, The Journal of Gastroenterology & Digestive Systems

Member             

Editorial Board, SM Journal of Carcinogenesis & Mutagenesis

Member             

Editorial Board, Journal of Gastroenterology, Hepatology, and Endoscopy

Member             

Editorial Board, The Scientific Pages of Drug Design and Development

Session Chair     

International Conference for Biomarkers and Clinical Research

 

Patent Applications

Lu, T and Prabhu, L. Small molecule protein arginine methyltransferase 5 (PRMT5) inhibitors and methods of treatment. International Patent Application PCT/US2017/058572, filed on October 26, 2017

Lu, T and Prabhu, L. Small molecule protein arginine methyltransferase 5 (PRMT5) inhibitors and methods of treatment. U.S. Provisional Patent Application 62/534,969, filed on July 20, 2017

Lu, T and Prabhu, L. Small molecule protein arginine methyltransferase 5 (PRMT5) inhibitors and methods of treatment. U.S. Provisional Patent Application 62/413,341, filed on October 26, 2016

Lu, T and Stark GR. Discovery of the FBXL11 as the negative regulator of NFkB. Filed to the Cleveland Clinic Invention Disclosure in July, 2007, in the process of provisional patent application.

Lu, T, Burdelya, LG, Stark GR and Gudkov AV. Methods of inhibiting apoptosis using latent TGFb.  U.S. provisional Patent No. 60/526,667, filed December 2, 2004.

 

 

Key Publications

Selected from 50 publications, Complete list of published work can be found at:

http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/48581694/?sort=date&direction=descending

1. Prabhu, L, Wei, H, Chen, L, Ozlem, D, Amero, A, Sandusky, G, Sun, E, Wang, J, Mo, J, Safa, A, Korc, M, Zhang, Z, and Lu, T*. Innovative AlphaLISA discovers a novel small-molecule inhibitor targeting PRMT5 in pancreatic and colon cancers. Oncotarget 8(25): 39963-39977, 2017. * Corresponding author. - 1) Selected for Cover Page, Priority Paper, 2) Honorable Mention Award, Cancer Research Day, 3) Honorable Mention, Erica M. Daniel Kepner Award for Scientific Achievement

2. Martin, M, Hua, L, Wang, B, Wei, H, Prabhu, L, Hartley, AV, Jiang, G, Liu, Y, and Lu, T*. Novel serine 176 phosphorylation of YBX1 activates NF-kB in colon cancer. J Biol Chem 292 (8): 3433-3444, 2017. * Corresponding author

3. Wang, B, Wei, H, Prabhu, L, Zhao, W, Martin, M, Hartley, A, and Lu, T*. Role of novel serine 316 phosphorylation of the p65 subunit of NF-kB in differential gene regulation. J Biol Chem 290 (33): 20336-20347, 2015 * Corresponding author - Selected for Donald Bowman Award

4. Lu, T* and Stark, GR*. NF-kB, regulation by methylation. Cancer Res 75 (18): 3692-3695, 2015. * Corresponding authors

5. Wei, H, Wang, B, She, Y, Gopalan, B, Miyagi, M, Stark, GR, and Lu, T*. PRMT5 dimethylates R30 of the p65 subunit to activate NF-kB. Proc Natl Acad Sci USA 110:13516-13521, 2013. *Corresponding Author. -1) Selected for F1000 Prime, 2) Hal Broxymeyer & Victoria Champion Outstanding Publication Award, 3) 2nd Place Award, Cancer Research Day

6. Lu, T*, Yang, M, Huang, D, Ghosh, G, and Stark GR. Role of lysine methyaltion of NF-kB in differential gene regulation. Proc Natl Acad Sci USA 110: 13510-13515, 2013. *Corresponding author - Selected for F1000 Prime

7. Zhang, T, Park, KA, Li, Y, Byun, HS, Jeon, J, Lee, Y, Hong, JH, Kim, JM, Huang, SM, Choi, SW, Kim, SH, Sohn, KC, Ro, H, Lee, JH, Lu, T, Stark, GR, Shen, HM, Liu, ZG, Park, J, and Hur, GM. PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65. Nat Commun 4:2062-2074, 2013. 

8. Stark, GR, Wang, Y, and Lu, T. Lysine methylation of promoter-bound transcription factors and relevance to cancer. Cell Res 21(3):375-380, 2011.

9. Lu, T*, Jackson, MW, Wang, B, Yang, M, Chance, M, Miyagi, M, Gudkov, AV, and Stark, GR*. Regulation of NF-kB by NSD1/FBXL11-dependent reversible lysine methyaltion of p65. Proc Natl Acad Sci USA 107: 46-51, 2010 *Corresponding authors

10. Lu, T and Stark, GR. Use of forward genetics to discover novel regulators of NF-kB. Book Chapter in Book "NF-kB". Editors: Michael Karin and Lou Staudt, Cold Spring Harbor Press, p253-264, 2010.

 

 

Connect


lut@iupui.edu 


(317) 278-0520 


PHARMACOLOGY & TOXICOLOGY
635 Barnhill Drive, MS 521 PHTX Indiana University School of Medicine
Indianapolis, IN 46202


  

Cancer

Titles & Appointments

  • Adjunct Assistant Professor of Biochemistry & Molecular Biology
  • Adjunct Assistant Professor of Medical & Molecular Genetics