21185-Du, Hong

Hong Du, PhD

Professor of Pathology & Laboratory Medicine

975 W. Walnut St.
Room IB 424E
Indianapolis, IN 46202
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 B.Sc., Wuhan University, Virology, Wuhan, China

 Ph.D., City University of  New York, Biochemistry, New York, NY

 Post Doctoral., The Rockefeller University, Molecular Biology and  Biochemistry, New York,  NY

Key Publications

1.         Ding, X., Lee, C., Du, H., and Yan, C. (2021) Lysosomal Acid Lipase Deficiency Controls Treg and Breg Homeostasis in the Lymph Nodes of Mice with Human Cancer Xenotransplants. Am J Pathol. 191:353-367. https://doi.org/10.1016/j.ajpath.2020.10.007. 

2.    Nguyen, H. D., Ticer, T., Bastian, D., Kuril, S., Li, H., Du, H., Yan, C., Yu, X. Z. (2020) Lysosomal Acid Lipase is required for Donor T Cells to Induce Graft-versus-Host Disease. Cell Reports. 33(4):108316. doi: 10.1016/j.celrep.2020.108316. PMID: 33113360

3.    Lee, C., Ding, X., Zhao, T., Wu, L., Du, H., Perkins, S., and Yan, C. (2019) Transthyretin Stimulates Tumor Growth through Regulation of Tumor, Immune and Endothelial Cells. J Immuol. 202: 991-1002.

       Zhao, T. Ding, X., Yan, C., and Du, H. (2017) Endothelial Rab7 GTPase in Tumor Growth and Metastasis. J Biol. Chem. 292:19198-19208. doi: 10.1074/jbc.M116.773093. PMID: 28924047.

5.    Ding, X., Zhang, W., Zhao, T., Du, H., and Yan, C. (2017) Rab7 GTPase controls lipid metabolic signaling in myeloid-derived suppressor cells. Oncotarget. In press.

6.    Du, H., Ding, X., and Yan, C (2017) Metabolic reprogramming of myeloid-derived suppressive cells. Oncoscience. In press.

7.    Zhao, T., Du, H., Blum J. S., and Yan, C. (2016) Lysosomal acid lipase is involved in mesenchyme stem cells’ stimulation of tumor growth and metastasis. Oncotarget. 7(38):61121-61135. doi: 10.18632/oncotarget.11244. PMID: 27531897

8.    Grumet, L., Eichmann, T.O., Taschler, U., Zierler, K. A., Leopold, C., Moustafa, T., Radovic, B., Romauch, M., Yan, C., Du, H., Haemmerle, G., Zechner, R., Fickert, P., Kratky, D., Zimmermann, R., and Lass, A. (2016) Lysosomal acid lipase hydrolyzes retinyl ester and affects retinoid turnover. J Biol Chem. 291(34):17977-87. doi: 10.1074/jbc.M116.724054.

9.    Radovic, B., Vujic, N., Leopold, C., Schlager, S., Goeritzer, M., Jay V. Patankar, J.V., Kolb, D., Reindl, J., Wegscheider, M., Birner-Grünberger, R., Schittmayer-Schantl, M., Groschner, L., Magnes, C., Diwoky, C., Sasa Frank, S., Steyrer, E., Zimmermann, R., Graier, W., Du, H. and Kratky, D. (2016) Hepatic regulation of increased insulin sensitivity in LAL-deficient mice. Diabetologia. 59:1743-52. doi: 10.1007/s00125-016-3968-6. Epub 2016 May 6.

10.    Zhao, T., Ding , X., Du, H., and Yan, C. (2016) Lung Epithelial Cell-Specific Expression of Human Lysosome Acid Lipase Corrects Lung Inflammation and Tumor Metastasis in lal−/− Mice. Am J Pathol. 186(8):2183-92. doi: 10.1016/j.ajpath.2016.04.014. PMID: 27461363

11.    Kumar, V., Cheng, P. Y., Condamine, T., McCaffrey, J.C., Hockstein, N., Witt, R., Masters, G., Bauer, T., Skrzypczynska, K., Weiss, A., Du, H., Yan C., and Gabrilovich, D.I. (2016) CD45 phosphotase regulates the fate of myeloid cells in tumor microenvironment by inhibiting STAT3 activity” Immunity 44(2):303-15. doi: 10.1016/j.immuni.2016.01.014.

12.    Zhao, T., Du, H., Blum J. S., and Yan, C (2016) Critical Role of PPARγ in Myeloid-Derived Suppressor Cell-Stimulated Cancer Cell Proliferation and Metastasis. Oncotarget. 12;7(2):1529-43. doi: 10.18632/oncotarget.6414

13.    Du, H., Zhao, T., Ding, X., and Yan, C. (2015) Hepatocyte-specific expression of human lysosomal acid lipase corrects liver inflammation and tumor metastasis in lal-/- mice. Am J Pathol. 185:2379-2389.

14. Zhao, T., Du, H., Ding, X., Walls, K., and Yan, C. (2015): Activation of mTOR Pathway in Myeloid-derived Suppressor Cells Stimulates Cancer Cell Proliferation and Metastasis in lal-/- Mice. Oncogene. 34:1938-48. Highlighted by Immune Regulation News 6.20.

15. Yan, C., Zhao, T. and Du, H. (2015) Lysosomal acid lipase in cancer. Editorial. Oncoscience, Invited Review. 2 (9):727-728

16. Ding, X., Wu, L., Yan, C. and Du, H. (2015): Establishment of lal-/- Myeloid Lineage Cell Line That Resembles Myeloid-derived Suppressive Cells. PLoS ONE. doi: 10.1371/journal.pone.0121001.

17. Huang, S. C., Everts, B., Ivanova, Y., O’Sullivan, D., Nascimento, M., Smith, A. M., Beatty, W., Love-Gregory, L., Lam, W. Y., O’Neill, C. M., Yan, C., Du, H., Abumrad, N. A., Urban, J. F., Artyomov, M., Pearce, E. L., Pearce, E. J. (2014) Cell-intrinsic lysosomal lipolysis is essential for macrophage alternative activation. Nature Immunology, 15:846-55.  

18. Zhao, T., Ding, X., Du, H., and Yan, C. (2014): Myeloid-derived Suppressor Cells Are Involved in Lysosomal Acid Lipase Deficiency-Induced Endothelial Cell Dysfunction.  J Immunol. 193:1942-53.

19. Sun, Y., Xu, Y. H., Du, H., Quinn, B., Liou, B., Stanton, L., Inskeep, V., Ran, H., Phillip Jakubowitz, P., Grilliot. N. and Grabowski, G.A. (2014) Reversal of advanced disease in lysosomal acid lipase deficient mice: a model for lysosomal acid lipase deficiency diseases. Molecular Genetics and Metabolism. 112:229-41.

20. Ferreira, A. E., Sisti, F., Sônego, F., Moreira, A. P., Filgueiras, L., Du, H., Cunha, F. Q., Alves-Filho, J. C., and Serezani, H. C. (2014) PPAR-g/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis.  J Immunol. 192:2357-65.

21. Ding, X., Du, H., Yoder, M. C., and Yan, C. (2014) Critical Role of the mTOR pathway in Development and Function of Myeloid-derived Suppressor Cells in lal-/- Mice. Am J. Pathol  184:397-408.

22. Yan, C., and Du, H. (2014) Functional role of lysosomal acid lipase in myeloid derived suppressive cell development and homeostasis. World J Immunol, Invited Review. 4: 42-51.

23. Yan, C., Ding, X., Wu, L., Yu, M., Qu, P., and Du, H. (2013): Stat3 Downstream Gene Product Chitinase 3-Like 1 Is a Potential Biomarker of Inflammation-induced Lung Cancer in Multiple Mouse Lung Tumor Models and Humans. PLoS ONE. 22;8(4):e61984. PMID:23613996.

24. Yan, C., Qu, P., and Du, H. (2012) Myeloid-Specific Expression of Stat3C Results in Conversion of Bone Marrow Stem Cells into Alveolar Type II Epithelial Cells in the Lung.  Sci China Life Sci. 55:576-590.

25. Wu, L.Y., Yan, C., Czader, M.B., Foreman, O., Blum J. S., Kapur, R., and Du, H.  (2012) Inhibition of peroxisome proliferator-activated receptor-g in myeloid lineage cells induces systemic inflammation, immunosuppression and tumorigenesis. Blood. 119:115-126.

26. Yan, C., Ding, X. C., Dasgupta, N., Qu, P., Wu, L.Y., and Du, H. (2012) Gene profile of myeloid-derived suppressive cells from the bone marrow of lysosomal acid lipase knock-out mice. PLoS ONE 7 (2): e30701.

27. Wu, L.Y., Du, H., Li, Y., Qu, P., and Yan, C (2011) Signal Transducers and activators of the transcription3 promotes myeloid derived suppressor cell expansion and immune suppression during lung tumorigenesis. Am. J. Pathol. 179:2131-2141.

28. Qu, P., Yan, C., Blum, J. S., Kapur, R., and Du, H. (2011) Myeloid-specific expression of human lysosomal acid lipase corrects malformation and malfunction of myeloid-derived suppressive cells in lal-/- mice. J. Immunol. 187:3854-3866.

29. Bowden, K.L., Bilbey, N. J., Bilawchuk, L.M., Boadu, E., Ory, D.S., Hegele, R.A., Du, H., Chan, T., and Francis, G.A. (2011) Lysosomal acid lipase deficiency impairs regulation of ABCA1 and formation of high density lipoproteins in cholesteryl ester storage disease. J. Biol. Chem. 286:30624-30635.

30. Li, Y., Qu, P., Wu, L.Y., Li, B. L., Du, H., and Yan, C. (2011) Api6/AIM/Spa overexpression in alveolar type II epithelial cells induces spontaneous lung adenocarcinoma. Cancer Res. 71:5488-5499.

31. Wu, L.Y, Wang, G.X., Qu, P., Yan, C., and Du, H. (2011) Overexpression of Dominant Negative Peroxisome Proliferator-Activated Receptor-gamma (PPARg) in Alveolar Type II Epithelial Cells Causes Inflammation and T-Cell Suppression in the Lung. Am. J. Pathol. 178: 2191-2204.

32. Qu, P., Yan, C., and Du, H. (2011) Matrix Metalloproteinase 12 overexpression in myeloid lineage cells plays a key role in modulating hepatopoiesis, myelopoiesis, immune suppression and lung tumorigenesis. Blood. 117: 4476-4489.

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