20845-Naidu, Samisubbu
Faculty

Samisubbu R. Naidu, PhD

Assistant Research Professor of Medicine

Address
950 West Walnut St, R2 E351


Indianapolis, IN 46202
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Bio

Dr. Naidu received PhD from University of Pune in India. He came to the United States as a Rockefeller Pre-doctoral Fellow to conduct PhD dissertation work at Washington State University, Pullman. His post-doctoral training was at University of Texas and University of Massachusetts Medical School. He joined Indiana University to start his independent research on metabolic pathways in mammalial cells.

Key Publications

Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth. Lakhter AJ, Hamilton J, Konger RL, Brustovetsky N, Broxmeyer HE, Naidu SR. J Biol Chem. 2016 Oct 14;291(42):21869-21879. Epub 2016 Aug 18. Highlighted by JBC virtual issue on Cancer: https://www.jbc.org/cancer

Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2. Shankar Babu M, Mahanta S, Lakhter AJ, Hato T, Paul S, Naidu SR. PLoS One. February 2, 2018 https://doi.org/10.1371/journal.pone.0191419

Ferroxitosis: a cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma. Lakhter AJ, Hamilton J, Dagher PC, Mukkamala S, Hato T, Dong XC, Mayo LD, Harris RA, Shekhar A, Ivan M, Brustovetsky N, Naidu SR. Oncotarget. 2014 Dec 30;5(24):12694-703.

Chloroquine promotes apoptosis in melanoma cells by inhibiting BH3 domain-mediated PUMA degradation. Lakhter AJ, Sahu RP, Sun Y, Kaufmann WK, Androphy EJ, Travers JB, Naidu SR. J Invest Dermatol. 2013 Sep;133(9):2247-54. doi: 10.1038/jid.2013.56. Epub 2013 Jan 31. Commentary: J Invest Dermatol. 2013. 133(9): p. 2133-5

Chromatin remodeling subunit BRM and valine regulate hematopoietic stem/progenitor cell function and self-renewal via intrinsic and extrinsic effects.
Naidu SR.* Capitano M, Ropa J, Cooper S, Huang X, Broxmeyer HE.* Leukemia. Oct., 2021
 *Corresponding author. 

Titles & Appointments

  • Assistant Research Professor of Medicine
  • Education
    2000 PhD University of Pune
    1991 MS Madurai Kamaraj University
    1989 BS Madurai Kamaraj University
  • Research

    Our research focus is to disect the metaboic pathways in endothelial cells to improve our understanding of angiogenesis.  

     

  • Publications
    Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth.
    Lakhter AJ; Hamilton J; Konger RL; Brustovetsky N; Broxmeyer HE; Naidu SR; The Journal of biological chemistry 2016 Aug 18
    Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
    Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Acevedo Arozena A; Adachi H; Adams CM; Adams PD; Adeli K; Adhihetty PJ; Adler SG; Agam G; Agarwal R; Aghi MK; Agnello M; Agostinis P; Aguilar PV; Aguirre-Ghiso J; Airoldi EM; Ait-Si-Ali S; Akematsu T; Akporiaye ET; Al-Rubeai M; Albaiceta GM; Albanese C; Albani D; Albert ML; Aldudo J; Algül H; Alirezaei M; Alloza I; Almasan A; Almonte-Beceril M; Alnemri ES; Alonso C; Altan-Bonnet N; Altieri DC; Alvarez S; Alvarez-Erviti L; Alves S; Amadoro G; Amano A; Amantini C; Ambrosio S; Amelio I; Amer AO; Amessou M; Amon A; An Z; Anania FA; Andersen SU; Andley UP; Andreadi CK; Andrieu-Abadie N; Anel A; Ann DK; Anoopkumar-Dukie S; Antonioli M; Aoki H; Apostolova N; Aquila S; Aquilano K; Araki K; Arama E; Aranda A; Araya J; Arcaro A; Arias E; Arimoto H; Ariosa AR; Armstrong JL; Arnould T; Arsov I; Asanuma K; Askanas V; Asselin E; Atarashi R; Atherton SS; Atkin JD; Attardi LD; Auberger P; Auburger G; Aurelian L; Autelli R; Avagliano L; Avantaggiati ML; Avrahami L; Awale S; Azad N; Bachetti T; Backer JM; Bae DH; Bae JS; Bae ON; Bae SH; Baehrecke EH; Baek SH; Baghdiguian S; Bagniewska-Zadworna A; Bai H; Bai J; Bai XY; Bailly Y; Balaji KN; Balduini W; Ballabio A; Balzan R; Banerjee R; Bánhegyi G; Bao H; Barbeau B; Barrachina MD; Barreiro E; Bartel B; Bartolomé A; Bassham DC; Bassi MT; Bast RC Jr; Basu A; Batista MT; Batoko H; Battino M; Bauckman K; Baumgarner BL; Bayer KU; Beale R; Beaulieu JF; Beck GR Jr; Becker C; Beckham JD; Bédard PA; Bednarski PJ; Begley TJ; Behl C; Behrends C; Behrens GM; Behrns KE; Bejarano E; Belaid A; Belleudi F; Bénard G; Berchem G; Bergamaschi D; Bergami M; Berkhout B; Berliocchi L; Bernard A; Bernard M; Bernassola F; Bertolotti A; Bess AS; Besteiro S; Bettuzzi S; Bhalla S; Bhattacharyya S; Bhutia SK; Biagosch C; Bianchi MW; Biard-Piechaczyk M; Billes V; Bincoletto C; Bingol B; Bird SW; Bitoun M; Bjedov I; Blackstone C; Blanc L; Blanco GA; Blomhoff HK; Boada-Romero E; Böckler S; Boes M; Boesze-Batt Autophagy 2016
  • Awards
    Org: The Rockefeller Foundation
    Desc: Rockefeller Predoctoral Fellowship
    Scope: International
    Date: 1996-06-01

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