20845-Naidu, Samisubbu
Faculty

Samisubbu R. Naidu, PHD

Assistant Research Professor of Medicine

Bio

Dr. Naidu received PhD from the University of Pune in India. He first visited the United States as a Rockefeller Pre-doctoral Fellow to conduct PhD dissertation work at the Washington State University, Pullman. He undertook post-doctoral training at the University of Texas and University of Massachusetts Medical School. He joined the Indiana University school of Medicine in late 2010 and his primary focus is metabolic plasticity in melanoma. 

 

Key Publications

Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth. Lakhter AJ, Hamilton J, Konger RL, Brustovetsky N, Broxmeyer HE, Naidu SR. J Biol Chem. 2016 Oct 14;291(42):21869-21879. Epub 2016 Aug 18.

Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2. Shankar Babu M, Mahanta S, Lakhter AJ, Hato T, Paul S, Naidu SR. PLoS One. February 2, 2018 https://doi.org/10.1371/journal.pone.0191419

Ferroxitosis: a cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma. Lakhter AJ, Hamilton J, Dagher PC, Mukkamala S, Hato T, Dong XC, Mayo LD, Harris RA, Shekhar A, Ivan M, Brustovetsky N, Naidu SR. Oncotarget. 2014 Dec 30;5(24):12694-703.

Chloroquine promotes apoptosis in melanoma cells by inhibiting BH3 domain-mediated PUMA degradation. Lakhter AJ, Sahu RP, Sun Y, Kaufmann WK, Androphy EJ, Travers JB, Naidu SR.J Invest Dermatol. 2013 Sep;133(9):2247-54. doi: 10.1038/jid.2013.56. Epub 2013 Jan 31. Commentary: J Invest Dermatol. 2013. 133(9): p. 2133-5 

 

 

 

 

 

 

 



Titles & Appointments

  • Assistant Research Professor of Medicine
  • Education
    2010 PhD University of Pune & Washington State University
    2000 PHD University of Pune
    2000 PHD University of Pune
    1991 MS Madurai Kamaraj University
    1991 MS Madurai Kamaraj University
    1991 MS Madurai Kamaraj University
    1989 BS Madurai Kamaraj University
    1989 BS Madurai Kamaraj University
    1989 BS Madurai Kamaraj University
  • Research

    My research focus is to define the metabolic vulnerabilities that can be exploited to develop an effective therapy for melanoma.  

    Although I began my independent research program to understand cell death mechanisms in melanoma, our investigations led us to the understanding that metabolic plasticity enable melanoma to resist cell death mechanisms. We are focusing on the following projects with a long-term goal of developing an effective therapy for melanoma.

    1. Define the mechanism of ferroxitosis: We reported a novel iron and oxygen dependent cell death called ferroxitosis. Redox cycling agent menadione promotes ferroxitosis in cells cultured under normoxic condition, yet activation of ferroxitosis under hypoxia is contingent upon depletion or inhibition of glycolytic enzyme PKM2. We are investigating the role of nuclear and/or cytosolic functions of PKM2 as well as mitochondrial Complexes in activation of ferroxitosis.

    2. Dissect the mechanism of acetate metabolism in melanoma: We reported that acetate metabolism synergizes with glutamine to support melanoma cell survival and tumor growth in a glucose-independent manner. BRAF mutant melanomas rapidly adapt to acetate metabolism in the absence of glucose. Because resistance to BRAF inhibitor therapy involves gain of mitochondrial metabolism, we are currently investigating the mechanism of mitochondrial acetate metabolism.

    3. Define the metabolic check points in hematopoietic stem cells: We are closely working with Dr. Broxmeyer to define the metabolic determinants that control hematopoietic stem cell self-renewal and expansion. My goal is to utilize the knowledge gained in melanoma metabolism to promote expansion of hematopoietic stem cell.  

     

  • Publications
    Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth.
    Lakhter AJ; Hamilton J; Konger RL; Brustovetsky N; Broxmeyer HE; Naidu SR; The Journal of biological chemistry 2016 Aug 18
    Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
    Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Acevedo Arozena A; Adachi H; Adams CM; Adams PD; Adeli K; Adhihetty PJ; Adler SG; Agam G; Agarwal R; Aghi MK; Agnello M; Agostinis P; Aguilar PV; Aguirre-Ghiso J; Airoldi EM; Ait-Si-Ali S; Akematsu T; Akporiaye ET; Al-Rubeai M; Albaiceta GM; Albanese C; Albani D; Albert ML; Aldudo J; Algül H; Alirezaei M; Alloza I; Almasan A; Almonte-Beceril M; Alnemri ES; Alonso C; Altan-Bonnet N; Altieri DC; Alvarez S; Alvarez-Erviti L; Alves S; Amadoro G; Amano A; Amantini C; Ambrosio S; Amelio I; Amer AO; Amessou M; Amon A; An Z; Anania FA; Andersen SU; Andley UP; Andreadi CK; Andrieu-Abadie N; Anel A; Ann DK; Anoopkumar-Dukie S; Antonioli M; Aoki H; Apostolova N; Aquila S; Aquilano K; Araki K; Arama E; Aranda A; Araya J; Arcaro A; Arias E; Arimoto H; Ariosa AR; Armstrong JL; Arnould T; Arsov I; Asanuma K; Askanas V; Asselin E; Atarashi R; Atherton SS; Atkin JD; Attardi LD; Auberger P; Auburger G; Aurelian L; Autelli R; Avagliano L; Avantaggiati ML; Avrahami L; Awale S; Azad N; Bachetti T; Backer JM; Bae DH; Bae JS; Bae ON; Bae SH; Baehrecke EH; Baek SH; Baghdiguian S; Bagniewska-Zadworna A; Bai H; Bai J; Bai XY; Bailly Y; Balaji KN; Balduini W; Ballabio A; Balzan R; Banerjee R; Bánhegyi G; Bao H; Barbeau B; Barrachina MD; Barreiro E; Bartel B; Bartolomé A; Bassham DC; Bassi MT; Bast RC Jr; Basu A; Batista MT; Batoko H; Battino M; Bauckman K; Baumgarner BL; Bayer KU; Beale R; Beaulieu JF; Beck GR Jr; Becker C; Beckham JD; Bédard PA; Bednarski PJ; Begley TJ; Behl C; Behrends C; Behrens GM; Behrns KE; Bejarano E; Belaid A; Belleudi F; Bénard G; Berchem G; Bergamaschi D; Bergami M; Berkhout B; Berliocchi L; Bernard A; Bernard M; Bernassola F; Bertolotti A; Bess AS; Besteiro S; Bettuzzi S; Bhalla S; Bhattacharyya S; Bhutia SK; Biagosch C; Bianchi MW; Biard-Piechaczyk M; Billes V; Bincoletto C; Bingol B; Bird SW; Bitoun M; Bjedov I; Blackstone C; Blanc L; Blanco GA; Blomhoff HK; Boada-Romero E; Böckler S; Boes M; Boesze-Batt Autophagy 2016
  • Awards
    Org: The Rockefeller Foundation
    Desc: Rockefeller Predoctoral Fellowship
    Scope: International
    Date: 1996-06-01

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