Fletcher A. White, MS, PhD
Vergil K. Stoelting Professor of Anesthesia
Professional: I am a medically-trained neuroscientist involved in both pre-clinical and clinical research studies for nearly 30 years. My experience in medical/graduate education and university leadership positions at two nationally recognized medical schools (Loyola University, Chicago and Indiana University) provides me with a multitude of resources for conducting basic and translational research.
Hobbies: Hiking, travel, reading, ACDs, social issues.
Chen X, Liu D, Zhou D, Si Y, Xu D, Stamatkin CW, Ghozayel MK, Ripsch MS, Obukhov AG, White FA, Meroueh SO.
Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10566-E10575. doi: 10.1073/pnas.1813157115. Epub 2018 Oct 24.
Allette YM, Kim Y, Randolph AL, Smith JA, Ripsch MS, White FA.
Sci Rep. 2017 Jun 16;7(1):3741. doi: 10.1038/s41598-017-03447-9.
Weber DJ, Allette YM, Wilkes DS, White FA.
Antioxid Redox Signal. 2015 Dec 10;23(17):1316-28. doi: 10.1089/ars.2015.6299. Epub 2015 May 14. Review.
White FA, Sun J, Waters SM, Ma C, Ren D, Ripsch M, Steflik J, Cortright DN, Lamotte RH, Miller RJ.
Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14092-7. Epub 2005 Sep 20.
NB 514D, Neuroscience Research Bldg.
Titles & Appointments
- Professor of Pharmacology & Toxicology
- Professor of Ophthalmology
- Research Career Scientist, Roudebusch Veterans Administration Medical Center
A large proportion of my research has been directed at the influence of tissue-derived factors on the nervous system during development and following disease/trauma. The body of this work includes the role of neurotrophins during neurodevelopment/apoptosis(NGF/TrkA & NT3/TrkC), axon guidance molecules during development (semaphorins), the role of chemokines/receptors in adult rodent injury models (CCL2/CCR2 and CXCL12/CXCR4), the influence of toll-like receptor-4 (TLR4) in the peripheral nervous system, study of drug-induced changes in voltage-gated sodium channels such as NaV1.7, and the influence of damage-associated molecular patterns (DAMPs) and their cognate receptors in both neuropathic pain syndromes and following traumatic brain injury.
As PI or co-investigator on several university-, state-, NIH-, and DOD-funded grants, I have established productive intramural and extramural research collaborations allowing me to utilize a variety of injury models including a newly developed closed head injury in mice. We have numerous molecular biological techniques, transgenic mice (CRISPR knockouts, Cre-lox tissue-specific knockout, optogenetic and GCamp3 lines), neuroanatomical tract tracing, electrophysiology (current and voltage clamp), telemetry, immunocytochemistry, stimulus dependent and independent measures of rodent behavior and access to both clinical databases and specimens. A most recent addition to the laboratory is the pre-clinical and clinical use of electroacupuncture to treat the effects of trauma on both the peripheral and central nervous system.
IU researchers isolate inflammatory process that damages lungs of donors with traumatic brain injury2014-09-03
Association for Clinical & Translational Sciences
International Association for the Study of Pain
National Neurotrauma Society
Society for Neuroscience
National Neurotrauma Society Conference
Peripheral Organ Involvement in CNS Trauma
The effects of TBI on peripheral immune cell responses