1972-Blum, Janice
Faculty

Janice S. Blum, PHD

Interim Vice Chancellor for Research and Graduate Education, IUPUI

Titles & Appointments

  • Interim Vice Chancellor for Research and Graduate Education, IUPUI
  • Associate Vice Chancellor for Graduate Education, IUPUI
  • Associate Dean, University Graduate School
  • Chancellor's Professor, IUPUI
  • Professor of Microbiology & Immunology
  • Education
    1984 PhD Duke University
    1984 PHD Duke University
    1984 PHD Duke University
    1979 BS The Pennsylvania State University
    1979 BS Pennsylvania State University
    1979 BS Pennsylvania State University
  • Research

    Immune responsiveness in humans and its role in protective immunity to tumors and pathogens as well as predisposition to autoimmune disease.

    Immune responsiveness in humans and the importance of immunological recognition pathways in protective immunity against tumors and pathogens as well as predisposition to autoimmune disease such as type I diabetes and arthritis. Distinguishing self and foreign antigens is a key step in the development of host immunity. Studies in Dr. Blum's laboratory are directed at understanding how protein antigens are processed for recognition by the immune system, and the events which regulate immune responses to foreign and self proteins.  Studies by Dr. Blum's group focus on cell biology and molecular approaches to examine the pathways guiding protein antigen trafficking, antigen processing and the selection of epitopes for presentation by MHC molecules. Discoveries by the Blum laboratory include work demonstrating the importance a novel thiol reductase GILT and NADPH oxidase MHC-restricted immune recognition, and a role for heat shock proteins and lysosomal membrane proteins in immune recognition by MHC class II molecules.  Studies by the Blum laboratory also have demonstrated endosomal recycling and autophagy are important pathways guiding immune responses.   Studies are on-going to understand how immune deficiency as well as hyper-responsiveness are regulated by these pathways.  These investigators have implications in terms of developing more efficient vaccine reagents specific for pathogens as well as tumors.  Studies by the Blum laboratory also strongly support a role for these pathways in regulating immune responses to autoantigens linked to the development of arthritis and diabetes in humans. Information from these studies is being applied identify new biomarkers for autoimmunity and inflammation, to design and test novel vaccines for promoting immunity to pathogens and tumors, and identify new targets for gene therapy to control immune responsiveness.

  • Awards
    Org: Indiana University Purdue Univesity at Indianapolis
    Desc: Outstanding Woman Leader - Faculty Award
    Scope: Campus
    Date: 2017-03-01
    Org: Indiana University School of Medicine - Department of Microbiology and Immunology
    Desc: Randy S. Rosenthal Graduate Student Advocacy Award
    Scope: Department
    Date: 2013-04-01
    Org: Indiana University Purdue Univesity at Indianapolis, Department Microbiology and Immunology
    Desc: Most Supportive Faculty
    Scope: Campus
    Date: 2012-06-01
    Org: Indiana University School of Medicine - Department of Microbiology and Immunology
    Desc: Randy S. Rosenthal Graduate Student Advocacy Award
    Scope: Department
    Date: 2011-04-01
    Org: Indiana University Purdue Univesity at Indianapolis, Department Microbiology and Immunology
    Desc: Most Supportive Faculty
    Scope: Campus
    Date: 2010-06-01
    Org: Indiana University School of Medicine
    Desc: Trustee Teaching Award
    Scope: School
    Date: 2008-05-01
    Org: Alliance of Distinguished and Titled Professors, Indiana University
    Desc:
    Scope: University
    Date: 2008-04-01
    Org: Indiana University Purdue Univesity at Indianapolis
    Desc: Chancellor's Professor
    Scope: Campus
    Date: 2008-04-01
    Org: Indiana University School of Medicine - Department of Microbiology and Immunology
    Desc: Randy S. Rosenthal Graduate Student Advocacy Award
    Scope: Department
    Date: 2008-04-01
    Org: Indiana University School of Medicine - Department of Microbiology and Immunology
    Desc: Randy S. Rosenthal Graduate Student Advocacy Award
    Scope: Department
    Date: 2005-04-01
    Org: University of Oklahoma
    Desc: Juneann Murphy Award for Excellence in Research and Mentoring
    Scope: International
    Date:

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