Kenneth E. White, PhD
Dr. White received a PhD in Pharmacology and Toxicology from Dartmouth Medical School, then studied the molecular genetics of metabolic bone diseases during an NIH-sponsored postdoctoral fellowship at the Indiana University School of Medicine (IUSM). He played an instrumental role in discovering the novel hormone FGF23 during this time, and since then his laboratory has been funded to study FGF23 and its co-receptor Klotho. He is currently the David D. Weaver Professor in the Department of Medical and Molecular Genetics (MMGE). Within the University, he is Director of the MMGE Division of Molecular Genetics and Gene Therapy and currently a member of the Indiana Center for Musculoskeletal Health (ICMH).
Titles & Appointments
- David D. Weaver Professor of Genetics
- Professor of Medical & Molecular Genetics
- Professor of Medicine
Molecular genetics of metabolic bone disorders
The White laboratory focuses on the molecular genetics of diseases associated with hyper- and hypophosphatemia and the resulting skeletal disease with a particular focus on the bone hormone FGF23 and interactions with its co-receptor alpha-Klotho (aKL). Work involves a unique FGF23 knock in animal model of autosomal dominant hypophosphatemia, as well as conditional and inducible genetic strains of mice. His group also undertakes parallel in vitro cell culture work in tissues derived from transgenic mice and skeletal and renal cell lines. Trainees coming through the White lab will undertake studies investigating the mechanisms underlying the target actions of FGF23 and a novel form or circulating aKL at the tissue level and through conditional in vivo approaches. Trainees will perform studies to test the regulation of FGF23 and aKL expression in bone and kidney cell models, respectively, including promoter and transcriptional assays. Trainees will also learn how to perform outcome measures in animal studies using biochemical analyses, dual-energy x-ray absorptiometry (DXA), and histomorphometrics, as well as a variety of hormone ELISAs. The goals of the in vitro studies performed by trainees is to provide comprehensive learning in luciferase and promoter (ChIP) studies, qPCR, ELISA, and additional molecular techniques (including RNA extraction, qPCR, and site-directed mutagenesis).
- Course Number: G716, Biomed II course: Molecular Biology and Genetics
- Course Number: G727 Animal Models of Human Disease
Desc: Chancellor's Professorship
Desc: David D. Weaver Professorship