Kenneth E. White, PhD
Chancellor's Professor
David D. Weaver Professor of Genetics
Professor of Medical & Molecular Genetics
Professor of Medicine
Division Chief
- kenewhit@iu.edu
- Address
-
635 Barnhill Drive
MS5010 (office)
Indianapolis, IN 46202 - PubMed:
Bio
Dr. White received a PhD in Pharmacology and Toxicology from Dartmouth Medical School, then studied the molecular genetics of metabolic bone diseases during an NIH-sponsored postdoctoral fellowship at the Indiana University School of Medicine (IUSM). He played an instrumental role in discovering the novel hormone FGF23 during this time, and since then his laboratory has been funded to study FGF23 and its co-receptor Klotho. He is currently the David D. Weaver Professor in the Department of Medical and Molecular Genetics (MMGE). Within the University, he is Director of the MMGE Division of Molecular Genetics and Gene Therapy and currently a member of the Indiana Center for Musculoskeletal Health (ICMH).
Year | Degree | Institution |
---|---|---|
1997 | PhD | Dartmouth College |
1988 | BS | State University of New York at Binghamton |
Molecular genetics of metabolic bone disorders
The White laboratory focuses on the molecular genetics of diseases associated with hyper- and hypophosphatemia and the resulting skeletal disease with a particular focus on the bone hormone FGF23 and interactions with its co-receptor alpha-Klotho (aKL). Work involves a unique FGF23 knock in animal model of autosomal dominant hypophosphatemia, as well as conditional and inducible genetic strains of mice. His group also undertakes parallel in vitro cell culture work in tissues derived from transgenic mice and skeletal and renal cell lines. Trainees coming through the White lab will undertake studies investigating the mechanisms underlying the target actions of FGF23 and a novel form or circulating aKL at the tissue level and through conditional in vivo approaches. Trainees will perform studies to test the regulation of FGF23 and aKL expression in bone and kidney cell models, respectively, including promoter and transcriptional assays. Trainees will also learn how to perform outcome measures in animal studies using biochemical analyses, dual-energy x-ray absorptiometry (DXA), and histomorphometrics, as well as a variety of hormone ELISAs. The goals of the in vitro studies performed by trainees is to provide comprehensive learning in luciferase and promoter (ChIP) studies, qPCR, ELISA, and additional molecular techniques (including RNA extraction, qPCR, and site-directed mutagenesis).
Kuthiroly S; Yesodharan D; Ghosh A; White KE; Nampoothiri S; Journal of pediatric genetics 2017 May 5
Knab VM; Corbin B; Andrukhova O; Hum JM; Ni P; Rabadi S; Maeda A; White KE; Erben RG; Jüppner H; Christov M; Endocrinology 2017 May 1
Clinkenbeard EL; White KE; Bone 2017 Jan 31
Hum JM; Clinkenbeard EL; Ip C; Cass TA; Allen M; White KE; Bone reports 2017 Jan 17
Clinkenbeard EL; Hanudel MR; Stayrook KR; Appaiah HN; Farrow EG; Cass TA; Summers LJ; Ip CS; Hum JM; Thomas JC; Ivan M; Richine BM; Chan RJ; Clemens TL; Schipani E; Sabbagh Y; Xu L; Srour EF; Alvarez MB; Kacena MA; Salusky IB; Ganz T; Nemeth E; White KE; Haematologica 2017 Aug 17
Ramnitz MS; Gourh P; Goldbach-Mansky R; Wodajo F; Ichikawa S; Econs MJ; White KE; Molinolo A; Chen MY; Heller T; Del Rivero J; Seo-Mayer P; Arabshahi B; Jackson MB; Hatab S; McCarthy E; Guthrie LC; Brillante BA; Gafni RI; Collins MT; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2016 Sep 20
Hum JM; O'Bryan L; Smith RC; White KE; Bone 2016 Nov 23
Hum JM; O'Bryan LM; Tatiparthi AK; Cass TA; Clinkenbeard EL; Cramer MS; Bhaskaran M; Johnson RL; Wilson JM; Smith RC; White KE; Journal of the American Society of Nephrology : JASN 2016 Nov 11
Clinkenbeard EL; Cass TA; Ni P; Hum JM; Bellido T; Allen MR; White KE; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2016 Mar 4
Clinkenbeard EL; White KE; Current molecular biology reports 2016 Feb 3
Murali SK; Andrukhova O; Clinkenbeard EL; White KE; Erben RG; PLoS biology 2016 Apr 1
Fleet JC; Replogle RA; Reyes-Fernandez P; Wang L; Zhang M; Clinkenbeard EL; White KE; Endocrinology 2015 Nov 20
White KE; Hum JM; Econs MJ; Current osteoporosis reports 2014 Sep
Ichikawa S; Gray AK; Padgett LR; Allen MR; Clinkenbeard EL; Sarpa NM; White KE; Econs MJ; Endocrinology 2014 Jul 22
Wolf M; White KE; Current opinion in nephrology and hypertension 2014 Jul
Clinkenbeard EL; Farrow EG; Summers LJ; Cass TA; Roberts JL; Bayt CA; Lahm T; Albrecht M; Allen MR; Peacock M; White KE; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014 Feb
Roberts J; Torres-Martinez W; Farrow E; Stevens A; Delk P; White KE; Weaver DD; American journal of medical genetics. Part A 2013 Dec 5
Smith RC; O'Bryan LM; Farrow EG; Summers LJ; Clinkenbeard EL; Roberts JL; Cass TA; Saha J; Broderick C; Ma YL; Zeng QQ; Kharitonenkov A; Wilson JM; Guo Q; Sun H; Allen MR; Burr DB; Breyer MD; White KE; The Journal of clinical investigation 2012 Nov 26
Farrow EG; Yu X; Summers LJ; Davis SI; Fleet JC; Allen MR; Robling AG; Stayrook KR; Jideonwo V; Magers MJ; Garringer HJ; Vidal R; Chan RJ; Goodwin CB; Hui SL; Peacock M; White KE; Proceedings of the National Academy of Sciences of the United States of America 2011 Oct 17
Farrow EG; Imel EA; White KE; Best practice & research. Clinical rheumatology 2011 Oct
Moe SM; Radcliffe JS; White KE; Gattone VH 2nd; Seifert MF; Chen X; Aldridge B; Chen NX; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011 Nov
Rhee Y; Bivi N; Farrow E; Lezcano V; Plotkin LI; White KE; Bellido T; Bone 2011 Jun 25
Farrow EG; Summers LJ; Schiavi SC; McCormick JA; Ellison DH; White KE; The Journal of endocrinology 2010 Jul 30
Farrow EG; White KE; Nature reviews. Nephrology 2010 Feb 23
Farrow EG; White KE; Expert review of endocrinology & metabolism 2009 Sep 1
Farrow EG; Davis SI; Summers LJ; White KE; Journal of the American Society of Nephrology : JASN 2009 Apr 8
Moe SM; Chen NX; Seifert MF; Sinders RM; Duan D; Chen X; Liang Y; Radcliff JS; White KE; Gattone VH 2nd; Kidney international 2008 Sep 17
Farrow EG; Davis SI; Ward LM; Summers LJ; Bubbear JS; Keen R; Stamp TC; Baker LR; Bonewald LF; White KE; Bone 2008 Oct 25
Garringer HJ; Malekpour M; Esteghamat F; Mortazavi SM; Davis SI; Farrow EG; Yu X; Arking DE; Dietz HC; White KE; American journal of physiology. Endocrinology and metabolism 2008 Aug 5
Ichikawa S; Imel EA; Kreiter ML; Yu X; Mackenzie DS; Sorenson AH; Goetz R; Mohammadi M; White KE; Econs MJ; The Journal of clinical investigation 2007 Sep
Garringer HJ; Mortazavi SM; Esteghamat F; Malekpour M; Boztepe H; Tanakol R; Davis SI; White KE; American journal of medical genetics. Part A 2007 Oct 15
Garringer HJ; Fisher C; Larsson TE; Davis SI; Koller DL; Cullen MJ; Draman MS; Conlon N; Jain A; Fedarko NS; Dasgupta B; White KE; The Journal of clinical endocrinology and metabolism 2006 Jul 25
White KE; Larsson TE; Econs MJ; Endocrine reviews 2006 Feb 7
Larsson T; Davis SI; Garringer HJ; Mooney SD; Draman MS; Cullen MJ; White KE; Endocrinology 2005 Jun 16
Yu X; Sabbagh Y; Davis SI; Demay MB; White KE; Bone 2005 Jun
Yu X; White KE; Cytokine & growth factor reviews 2005 Feb 5
Larsson T; Yu X; Davis SI; Draman MS; Mooney SD; Cullen MJ; White KE; The Journal of clinical endocrinology and metabolism 2005 Feb 1
Yu X; Ibrahimi OA; Goetz R; Zhang F; Davis SI; Garringer HJ; Linhardt RJ; Ornitz DM; Mohammadi M; White KE; Endocrinology 2005 Aug 4
Yu X; White KE; Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 2005 Aug
White KE; Cabral JM; Davis SI; Fishburn T; Evans WE; Ichikawa S; Fields J; Yu X; Shaw NJ; McLellan NJ; McKeown C; Fitzpatrick D; Yu K; Ornitz DM; Econs MJ; American journal of human genetics 2004 Dec 28
Desc: Trustee Teaching Award
Scope: University
Date: 2024-04-01
Desc: Excellence in Faculty Mentoring Award- Basic Science
Scope: School
Date: 2023-09-01
Desc: Chancellor's Professorship
Scope: Campus
Date: 2017-04-01
Desc: David D. Weaver Professorship
Scope: Department
Date: 2015-07-01