1911-Broxmeyer, Hal
Faculty

Hal E. Broxmeyer, PhD

Distinguished Professor

Address
R2 302
950 W. Walnut St.

Indianapolis, IN

Bio

Hal E. Broxmeyer, Ph.D. is Distinguished Professor, Mary Margaret Walther Professor Emeritus, and Professor of Microbiology and Immunology, and Co-Leader, Program on Hematopoiesis and Hematologic Malignancies, NCI-Designated Indiana University Simon Cancer Center (since 1990s) at the Indiana University School of Medicine (IUSOM), Indianapolis, IN. He is the former Chairman of Microbiology and Immunology (1997-September 2010), Scientific Director of the Walther Oncology Center (1988-2009), and Professor of Medicine (1986-2009) at the IUSM. He received a BS degree, Brooklyn College, City University of New York (1966), MS degree from Long Island University, Brooklyn Center (1969) and PhD from New York University (1973).  He did post-doctoral training at Kingston General Hospital, Queens University Kingston, Ontario, Canada (1973-1975).  He worked at the Memorial Sloan Kettering Cancer Center (MSKCC) in New York City (1975-1983) rising from the rank of Associate Researcher (advanced post-doc) to Associate Member.  He was also Assistant Professor of Biology, Sloan Kettering Division of Cornell University Graduate School of Medical Sciences, New York, before being recruited to the IUSOM in 1983 as an Associate Professor of Medicine and Director of Cancer Research of the Regenstrief Foundation. To date, he has published 789 scientific papers (542 refereed papers and 247 Reviews/Book Chapters). The papers have been cited 64,800 times with an h-factor of 120 and an i10 index of 570 (Google Scholar); with h-factor of 104 (Web of Science) as of Feb. 2019. Dr. Broxmeyer’s Awards include: New York University Founders Day Award (1973); Mellor Award (2nd prize 1976; 1st prize 1977) and Boyer Award (1983) from MSKCC; Special Fellow (1976-1978) and Scholar Award (1978-1983) from the Leukemia Lymphoma Society; Merit Award, National Cancer Institute (1987-1995, for his studies on actions of growth factors); Variety Club Award (1992 and 1993), Indiana; Gold Medal of City of Paris (1993); World of Difference Award, Indiana Health Industry Forum (1997); Who’s Who in Health Care, Indianapolis Business Journal (IBJ) (2002); Health Care Heroes Award, IBJ (2002); Karl Landsteiner Award, American Association of Blood Banks (2002); Prestigious External Award Recognition, IUPUI (2003); Distinguished Alumni Award, Long Island University  (2005); Joseph T. Taylor Excellence in Diversity Award, Indiana University (2006); Dirk van Bekkum Award, Autologous Blood and Bone Marrow Society (2006); E. Donnall Thomas Prize and Lecture, American Society of Hematology (2007); Glenn W. Irwin Jr. M.D., Distinguished Faculty Award, Indiana University School of Medicine Alumni Association (2008); State of Indiana General Assembly House Resolution No. 46 (2008); Till and McCulloch Lecture Award from Canadian Blood and Marrow Transplant Group (2010); George Stamatoyannopoulos Lecture Award, American Society of Gene and Cellular Therapy (2010); 2011 International Society of Hematology and Stem Cell Research (ISEH) Donald Metcalf Award; 41st Annual Schueler Distinguished Lecture in Pharmacology, Tulane Medical School (2013); elected Fellow of the American Association for the Advancement of Science (AAAS), 2012; Honorary Professorship, Peking Union Medical College, Beijing, China, (2014); Thought Leader Award for Cord Blood Transplantation, 15th Annual International Cord Blood Conference, (2017); NHLBI Outstanding Investigator (R35) Award, (2018).  Dr. Broxmeyer is Chairman Emeritus, Board of Directors, National Disease Research Interchange (NDRI), Philadelphia, PA. He was 1991 President of the International Society for Hematology and Stem Cell Research (ISEH), and was 2010 President, American Society of Hematology (ASH; only non-MD in the history of ASH to become President). His personal research involves mechanisms of regulation of hematopoiesis in context of stem cells/progenitor cells/cytokines.  He uses animal models to evaluate physiological activities of cytokines and cytokine combinations, and the influence of protein truncation by Dipeptidylpeptidase 4 (DPP4/CD26) on cytokine/chemokine activity. His studies on stem/progenitor cell kinetics of patients receiving various cytokines, have suggested means to better utilize these cytokines for efficacious use.  He evaluates alternative sources of transplantable hematopoietic stem and progenitor cells and was a discoverer of the utility of umbilical cord blood for this purpose.  His laboratory studies and first proof of principle cord blood bank in his laboratory set the stage for their clinical use, and he helped design the first clinical transplants that lead to their successful use. The first five of five, and seven of ten transplants of the more than 40,000 now performed were done with cord blood tested and frozen in his laboratory and hand-delivered to the transplant site. His group demonstrated that Extra Physiologic Oxygen Shock/Stress (EPHOSS) when cells are collected/processed in ambient air is detrimental to stem cells, effects mitigated by collecting/processing bone marrow and cord blood in hypoxia (3% O2) or with cyclosporine A in ambient air, for a more efficacious stem cell collection of potential clinical relevance (Cell, 2015). His laboratory efforts also led to the clinical studies he was involved in that established the hematopoietic stem and progenitor cell mobilizing capability of AMD3100, alone and in synergy with granulocyte colony stimulating factor.  Dr. Broxmeyer served on the Councils of ASH, ISEH, and the Society of Leukocyte Biology.  He served on numerous NIH and ACS study sections including on the NIH Hematology II Study Section twice for 5 years each time (and was Chairman for last 3 years of second term) and was Advisory Member for NHLBI of the NIH.  He has served three 5 year terms as a member of the Scholar, Special Fellow and Fellow grant review committee for the Leukemia Lymphoma Society. He is a long-time member of the advisory cord blood committee of the National Marrow Donor Program (NMDP), and served a two-year term on the HRSA/HHS committee on Blood Stem Cell Transplantation (2008-2010).  He was on the Board of Directors of the first cord blood banking company (Biocyte Corporation). He served as the chairman of the Board of Scientific Councilors, and on the External Advisory Board of the National Space Biomedical Research Institute (NSBRI/NASA). He has been on over 20 scientific Editorial Boards, including Blood, Experimental Hematology, the Journal of Immunology and Blood Cells, Molecules, and Diseases, and is currently on over 10 Editorial Boards,including the Journal of Experimental Medicine, and Stem Cells.  He is Senior Editor, Stem Cells and Development, and Consulting Editor for Journal of Clinical Investigation. His research has been continuously peer-review funded since 1976, and by the NIH since 1978 (usually with multiple NIH grants at the same time).

Key Publications

Recent Key Publications

 

Broxmeyer, H.E., Hoggatt, J., O’Leary, H.A., Mantel, C., Chitteti, B.R., Cooper, S., Messina-Graham, S., Hangoc, G., Farag, S., Rohrabaugh, S.L., Ou, X., Speth, J., Pelus, L.M., Srour, E.F., Campbell, T.B. 2012. Dipeptidylpeptidase 4 Negatively Regulates Colony Stimulating Factor Activity and Stress Hematopoiesis. Nature Medicine. 18:1786-1796. PMCID:PMC3742313

 

Mantel, C.R., O’Leary, H.A. Chitteti, B.R., Huang, X., Cooper, S., Hangoc, G., Brustovetsky, N., Srour, E.F., Lee, M.R., Messina-Graham, S., Haas, D.M., Falah, N., Kapur, R., Pelus, L.M., Bardeesy, N., Fitament, J., Ivan, M., Kim, K-S., and Broxmeyer, H.E. 2015. Enhancing hematopoietic stem cell transplantation efficacy by mitigating oxygen shock.  Cell. 161:1553-1565. PMCID:PMC4480616

 

O’Leary, Capitano, M.L., Cooper, S., Mantel, C., Boswell, S., Kapur, R., Ramdas, B., Chan, R., Deng, L., Skinner, H.D., Qui, C.K., and Broxmeyer, H.E. 2017. DPP4 truncated GM-CSF and IL-3 manifest distinct receptor binding and regulatory functions compared to their full length forms. Leukemia. 31:2468-2478. PMCID:PMC5650952

 

Guo, B., Huang, X., Lee, M.R., Lee, S.A., and Broxmeyer, H.E. 2018. Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis. Nat Med. 24(3):360-367. PMCID:PMC5875416

 

Huang, XX., Guo, B., and Broxmeyer, H.E. 2018. Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment. Nat Commun. 9(1):Article# 2741. PMCID:PMC6048146

 

Capitano, M., Zhao, L., Cooper, S., Thorsheim, C., Aae, S., Huang, X., Dent, A., Marks, M., Abrams, C.S., and Broxmeyer, H.E. 2018. Phosphatidylinositol Transfer Proteins Regulate Megakaryocyte TGF-b1 Secretion and Hematopoiesis in Mice. Blood. 132:1027-1038.  PMCID:PMC6128088 [Available on 2019-09-06]

Titles & Appointments

  • Distinguished Professor
  • Mary Margaret Walther Professor Emeritus
  • Professor of Microbiology & Immunology
  • Professor of Medicine
  • Education
    1973 PhD New York University
    1969 MS Long Island University
    1966 BS Brooklyn College
  • Research

    The laboratory focuses on mechanisms regulating proliferation, survival, self-renewal, metabolism, differentiation and homing/mobilization of hematopoietic, embryonic, and induced pluripotent stem cells at cellular, intracellular, and animal levels, as well as gene transfer, to influence these functions.

    Dr. Broxmeyer's laboratory is interested in blood cell production (hematopoiesis) in the context of normal and abnormal cell regulation as assessed in vitro and in vivo.  As a clinical correlate, his laboratory is interested in the use of hematopoietic stem and progenitor cells, especially those from umbilical cord blood, for transplantation purposes, and the use of cytokines/chemokines for treatment of hematological disorders.  His laboratory has been involved in studies assessing and establishing the use of cord blood for transplantation, and in vivo effects of cytokines, especially in patients on clinical trial.  His laboratory demonstrated that inactivation/deletion of the peptidase activity of CD26/Dipeptidylpeptidase (DPP) IV on murine and human stem cells greatly enhances their homing and engraftment capability and clinical trials are ongoing to use this to enhance engraftment of cord blood cells, and that DPPIV can truncate and change the activity of a number of growth regulating factors. They have demonstrated the potent stem and progenitor cell mobilizing capacity of AMD3100, an antagonist of SDF-1/CXCL12 binding to its receptor CXCR4, that led the clinical trials with AMD3100 in this context.  Most recently they demonstrated that removal of hematopoietic stem cells under ambient air as everyone does acts as a strong stress that immediately differentiates them and this greatly reduces their numbers, and that reduction of this stress results in greatly enhanced recovery of numbers of transplantable stem cells.  They have also found new means to ex-vivo expand hematopoietic stem cells, and to enhance their homing and engrafting capabilities. The laboratory also studies maintenance and hematopoietic differentiation of embryonic and induced pluripotent stem cells. Intracellular signal transduction studies are utilized to evaluate mechanisms of cell proliferation and survival, mobilization of cells from the marrow to the blood, and homing from blood to marrow. This includes viral-gene transfer approaches. Mice in which specific genes are either deleted or inserted are utilized to determine dominant regulatory effector proteins.  Recent studies have focused on: metabolism and mitochondria.

  • Publications
    Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment.
    Dong L; Yu WM; Zheng H; Loh ML; Bunting ST; Pauly M; Huang G; Zhou M; Broxmeyer HE; Scadden DT; Qu CK; Nature 2016 Oct 26
    Erythropoietin modulation is associated with improved homing and engraftment post umbilical cord blood transplantation.
    Aljitawi OS; Paul S; Ganguly A; Lin TL; Ganguly S; Vielhauer G; Capitano ML; Cantelina A; Lipe B; Mahnken JD; Wise A; Berry A; Singh AK; Shune L; Lominska C; Abhyankar S; Allin D; Laughlin M; McGuirk JP; Broxmeyer HE; Blood 2016 Oct 19
    Enhancing the efficacy of engraftment of cord blood for hematopoietic cell transplantation.
    Broxmeyer HE; Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2016 May 12
    Modulation of Hematopoietic Chemokine Effects In Vitro and In Vivo by DPP-4/CD26.
    Broxmeyer HE; Capitano M; Campbell TB; Hangoc G; Cooper S; Stem cells and development 2016 Mar 30
    MiR-31/SDHA Axis Regulates Reprogramming Efficiency through Mitochondrial Metabolism.
    Lee MR; Mantel C; Lee SA; Moon SH; Broxmeyer HE; Stem cell reports 2016 Jun 23
    Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth.
    Lakhter AJ; Hamilton J; Konger RL; Brustovetsky N; Broxmeyer HE; Naidu SR; The Journal of biological chemistry 2016 Aug 18
    Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
    Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Acevedo Arozena A; Adachi H; Adams CM; Adams PD; Adeli K; Adhihetty PJ; Adler SG; Agam G; Agarwal R; Aghi MK; Agnello M; Agostinis P; Aguilar PV; Aguirre-Ghiso J; Airoldi EM; Ait-Si-Ali S; Akematsu T; Akporiaye ET; Al-Rubeai M; Albaiceta GM; Albanese C; Albani D; Albert ML; Aldudo J; Algül H; Alirezaei M; Alloza I; Almasan A; Almonte-Beceril M; Alnemri ES; Alonso C; Altan-Bonnet N; Altieri DC; Alvarez S; Alvarez-Erviti L; Alves S; Amadoro G; Amano A; Amantini C; Ambrosio S; Amelio I; Amer AO; Amessou M; Amon A; An Z; Anania FA; Andersen SU; Andley UP; Andreadi CK; Andrieu-Abadie N; Anel A; Ann DK; Anoopkumar-Dukie S; Antonioli M; Aoki H; Apostolova N; Aquila S; Aquilano K; Araki K; Arama E; Aranda A; Araya J; Arcaro A; Arias E; Arimoto H; Ariosa AR; Armstrong JL; Arnould T; Arsov I; Asanuma K; Askanas V; Asselin E; Atarashi R; Atherton SS; Atkin JD; Attardi LD; Auberger P; Auburger G; Aurelian L; Autelli R; Avagliano L; Avantaggiati ML; Avrahami L; Awale S; Azad N; Bachetti T; Backer JM; Bae DH; Bae JS; Bae ON; Bae SH; Baehrecke EH; Baek SH; Baghdiguian S; Bagniewska-Zadworna A; Bai H; Bai J; Bai XY; Bailly Y; Balaji KN; Balduini W; Ballabio A; Balzan R; Banerjee R; Bánhegyi G; Bao H; Barbeau B; Barrachina MD; Barreiro E; Bartel B; Bartolomé A; Bassham DC; Bassi MT; Bast RC Jr; Basu A; Batista MT; Batoko H; Battino M; Bauckman K; Baumgarner BL; Bayer KU; Beale R; Beaulieu JF; Beck GR Jr; Becker C; Beckham JD; Bédard PA; Bednarski PJ; Begley TJ; Behl C; Behrends C; Behrens GM; Behrns KE; Bejarano E; Belaid A; Belleudi F; Bénard G; Berchem G; Bergamaschi D; Bergami M; Berkhout B; Berliocchi L; Bernard A; Bernard M; Bernassola F; Bertolotti A; Bess AS; Besteiro S; Bettuzzi S; Bhalla S; Bhattacharyya S; Bhutia SK; Biagosch C; Bianchi MW; Biard-Piechaczyk M; Billes V; Bincoletto C; Bingol B; Bird SW; Bitoun M; Bjedov I; Blackstone C; Blanc L; Blanco GA; Blomhoff HK; Boada-Romero E; Böckler S; Boes M; Boesze-Batt Autophagy 2016
  • Awards
    Org: 15th Annual International Cord Blood Conference
    Desc: Thought Leader Award for Cord Blood Transplantation
    Scope: International
    Date: 2017-06-08
    Org: ISEH International Society for Hematology and Stem Cell Research, Vancouver, British Columbia, Canada
    Desc: Donald Metcalf Award
    Scope: International
    Date: 2011-08-01
    Org: American Society of Gene and Cellular Therapy, Washington, DC
    Desc: George Stamatoyannopoulos Lecture
    Scope: National
    Date: 2010-05-20
    Org: 12th Biennial Conference of the Canadian Blood and Marrow Transplant Group. Vancouver, Canada
    Desc: CBMTG Till and McCulloch Lecture Award
    Scope: International
    Date: 2010-04-08
    Org: International Umbilical Cord Blood Transplantation Symposium, Los Angeles, CA.
    Desc: Cord Blood Award for pioneering scientific studies on the biology of stem cells and contributions in the development of umbilical cord blood transplantation.
    Scope: International
    Date: 2008-06-06
    Org: Indiana University School of Medicine Alumni Association
    Desc: Glenn W. Irwin, Jr., M.D. Distinguished Faculty Award, for career accomplishments and service to the School of Medicine
    Scope: University
    Date: 2008-05-17
    Org: Indiana University Purdue University at Indianapolis (IUPUI)
    Desc: Prestigious External Award Recognition
    Scope: University
    Date: 2008-04-25
    Org: Indiana Chapter, Leukemia Lymphoma Society
    Desc: Mission Advancement Award, for advancing research and significantly impacting the lives of blood cancer patients
    Scope: State
    Date: 2008-04-18
    Org: American Society of Hematology
    Desc: E. Donnall Thomas Prize and Lecture (Recognizes a pioneer researcher in hematology who has made sustained high-impact contributions over an extended period of time)
    Scope: International
    Date: 2007-12-01
    Org: Yale University School of Medicine, oint Laboratory Medicine/Yale Cancer Center Grand Rounds
    Desc: 12th Annual Joseph R. Bove Visiting Professor Seminar
    Scope: National
    Date: 2006-11-28
    Org: Autologous Blood and Bone Marrow Society
    Desc: Dirk van Bekkum Award (bestowed on individuals who have made major contributions for a prolonged period of time to the field of hematopoietic stem cells and transplantation)
    Scope: International
    Date: 2006-11-03
    Org: Indiana University
    Desc: Joseph T. Taylor Excellence in Diversity Award
    Scope: University
    Date: 2006-02-22
    Org: Long Island University, Brooklyn Center
    Desc: Distinguished Alumni Award
    Scope: National
    Date: 2005-05-01
    Org: Indiana University
    Desc: Distinguished Professorship
    Scope: University
    Date: 2004-02-28
    Org: Indiana University Purdue University
    Desc: Prestigious External Award Recognition
    Scope: University
    Date: 2003-04-25
    Org: American Association of Blood Banks
    Desc: Karl Landsteiner Award
    Scope: International
    Date: 2002-10-01
    Org: Indianapolis Business Journal
    Desc: Health Care Heroes Award winner for Advancements in Health Care Category
    Scope: Local
    Date: 2002-03-01
    Org: Indiana Health Industry Forum
    Desc: World of Difference Award for Outstanding Achievements in Healthcare Delivery
    Scope: Local
    Date: 1997-10-23
    Org: City of Paris Mayor, Jacques Chirac (now President of France)
    Desc: Gold Medal of the City of Paris from the then Mayor, Jacques Chirac (now President of France) for research in hematopoiesis and support of the basic and clinical research effort in France
    Scope: International
    Date: 1993-04-19
    Org: IU School of Medicine
    Desc: Randy Rosenthal Teaching Award
    Scope: University
    Date:
    Org: National Institutes of Health
    Desc: Predoctoral Training Grant
    Scope: National
    Date:
    Org: National Institutes of Health/National Heart Lung Blood Institute
    Desc: R35 Outstanding Investigator Award
    Scope: National
    Date:
    Org: Peking Union Medical College, Beijing, China
    Desc: Honorary Professor
    Scope: International
    Date:
    Org: AAAS
    Desc: Elected Fellow
    Scope: National
    Date:
    Org: American Society of Hematology
    Desc: Vice-President (2008)
    Scope: International
    Date:
    Org: American Society of Hematology
    Desc: President-Elect (2009)
    Scope: International
    Date:
    Org: American Society of Hematology
    Desc: President (2010)
    Scope: International
    Date:
    Org: Indianapolis Business Journal, Vol. 23, No. 21
    Desc: Who’s Who In Health Care
    Scope: Local
    Date:
    Org: Fred Hutchinson Cancer Center
    Desc: E. Donnal Thomas Lecture
    Scope: National
    Date:
    Org: Variety Club
    Desc: Variety Club Heart Award (Given for outstanding research that benefits children)
    Scope: Local
    Date:
    Org: Variety Club
    Desc: Variety Club Heart Award (Given for outstanding research that benefits children)
    Scope: Local
    Date:
    Org: National Cancer Institute
    Desc: Merit Award
    Scope: National
    Date:
    Org: Sloan-Kettering Cancer Center
    Desc: Boyer Award for Laboratory Investigation (Highest Award from Sloan-Kettering to "Young" Staff Member)
    Scope: National
    Date:
    Org: Leukemia Society of America
    Desc: Scholar Award
    Scope: International
    Date:
    Org: Leukemia Society of America
    Desc: Special Fellow Award
    Scope: International
    Date:
    Org: 2nd Prize from Memorial Sloan-Kettering Cancer Center, 1976
    Desc: Mellor Award (In recognition of excellence in Cancer Research)
    Scope: National
    Date:
    Org: 1st Prize from Memorial Sloan-Kettering Cancer Center, 1977
    Desc: Mellor Award (In recognition of excellence in Cancer Research)
    Scope: National
    Date:
    Org: New York University
    Desc: New York University Founders Day Award (1973)
    Scope: National
    Date:

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