Jianyun (Jean) Liu, PhD

Bio

Dr. Liu currently serves as Assistant Research Professor in Pediatric Surgery. She received her doctoral degree in Molecular Biology from Virginia Tech and completed her postdoctoral training in Immunology at Indiana University School of Medicine.

Dr. Liu’s research interests include understanding immunological responses to the invasion of pathogens and tumors, and how modern lifestyle alters the innate T cells. She has contributed to more than 20 peer reviewed publications.

Dr. Liu is a member of the American Association of Immunologists.

Key Publications

Iyer AK, Liu J, Gallo RM, Kaplan MH, Brutkiewicz RR. (2015) STAT3 promotes CD1d-mediated lipid antigen presentation by regulating a critical gene in glycosphingolipid biosynthesis. Immunology 146 (3): 444-55 PMCID: PMC4610633

Walline CC1, Deffit SN, Wang N, Guindon LM, Crotzer VL, Liu J, Hollister K, Eisenlohr LC, Brutkiewicz RR, Kaplan MH, Blum JS. Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy. Immunology 141(4):531-9. PMID: 24205828

Gourapura, R.J., Khan, M.A., Gallo, R.M., Shaji, D., Liu, J., Brutkiewicz, R.R. Forming a complex with MHC class I molecules interferes with mouse CD1d functional expression. PLoS One 8(8):e72867, 2013. PMID: 24009709

Liu J, Glosson NL, Du W, Gervay-Hague J; Brutkiewicz RR (2013) A Thr/Ser dual residue motif in the cytoplasmic tail of human CD1d is important for the down-regulation of antigen presentation following an HSV-1 infection. Immunology 140:191-201, 2013. PMCID: PMC3784165.

Titles & Appointments

Assistant Research Professor of Surgery

Education

2006 PhD Virginia Polytechnic Institute and State University

1998 BS Lanzhou University
Research

Dr. Liu’s long term research interests include understanding immunological responses to the invasion of pathogens and tumors, and how modern lifestyle alters the innate T cells. Innate T cells are important immune cells that link the innate and adaptive immune systems. Different from conventional T cells, these cells quickly respond to non-peptide antigens presented by monomorphic non-MHC molecules and produce abundant pro-inflammatory and/or anti-inflammatory cytokines. We study the functions of innate T cells in different diseases, such as necrotizing enterocolitis (NEC), obesity, neurofibromatosis type I (NF1), etc. The goal is to study the mechanisms and develop therapeutic strategies utilizing innate T cells.
Professional Organizations

American Association of Immunologists

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