17612-Xu, Yan
Faculty

Yan Xu, PHD

Hulman-George Family Professor of Gynecologic Cancer

Bio

My main research interests deal with understanding at the molecular level the mechanism of development and progress of the molecular aspects of ovarian, prostate, colon and other cancers.  In particular, we are interested in tumor microenvironment and metastasis, as well as anoikis-resistance. These include developing effective diagnostic and prognostic biomarkers for these diseases, studying signaling mechanistic studies, identifying novel therapeutic targets and methods to treat them. Several mouse models have been established or under development to address mechanisms underlying tumor initiation, progression, and metastasis.

Our current research focuses: 1) investigate the role and signaling mechanisms of LPA and their receptors in ovarian and other cancers using both in vitro and in vivo studies; 2) study cancer stem cells; and 3) identify novel and efficacious ovarian cancer treatment targets.

Read more about the Yan Xu Lab.

Current Programs:

Tumor metastasis and microenvironment

Mouse models of ovarian cancer

Anoikis-resistance in ovarian cancer

Role of lysophospholipids in ovarian cancer

Development of diagnostic and prognostic markers for ovarian and other cancers

G protein coupled receptors for bioactive lysophospholipids and their signaling pathways

Investigators:

Qipeng Fan (Research Associate)

Titles & Appointments

  • Hulman-George Family Professor of Gynecologic Cancer
  • Professor of Obstetrics & Gynecology
  • Professor of Biochemistry & Molecular Biology
  • Education
    1988 PHD State University of New York at Albany
    1988 PhD Suny At Albany
    1988 PHD State University of New York at Albany
    1982 BS Beijing Normal University
    1982 BS Beijing Normal University
    1982 BSC Beijing Normal University
  • Research

    Molecular mechanisms of cancer development

    Role and signaling mechanisms of bioactive lysophospholipids and their receptors

    Development of ovarian cancer models

    Identification of novel and efficacious ovarian cancer treatment targets

    Cancer stem cells

     

    Collaborators:

    Li Zhang, professor, Toronto General Research Institute, University of Toronto.

    Liang Cheng, Professor of Pathology and Urology, Indiana University School of Medicine (IUSM). Randy R. Brutkiewicz, Ph.D. Professor of Microbiology and Immunology, IUSM.

    Kao, Chinghai, Associate Professor, Thomson Scholar of Prostate Cancer Research, IUSM

    Piccirillo, Ciriaco A., Associate professor, Department of Microbiology and Immunology, McGill University, Faculty of Medicine Center for the Study of Host resistance, MUHC.

    Jinwu Xie, Jonathan and Jennifer Simmons Professor of Pediatrics, Department of Pediatrics, IUSM.

    Zhong-yin Zhang, Robert A. Harris Professor and Chairman, Department of Biochemistry and Molecular Biology, IUSM.

    Liangpunsakul, Suthat, Associate Professor of Medicine, Adjunct Associate Professor in Public Health. IUSM.

    Ken Nephew, Professor, Indiana University School of Medicine.

    Mircea Ivan, Associate Professor, Department of Medicine, Division of Hematology/Oncology, IU School of Medicine.

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