My main research interests deal with understanding at the molecular level the mechanism of development and progress of the molecular aspects of ovarian, prostate, colon and other cancers. In particular, we are interested in tumor microenvironment and metastasis, as well as anoikis-resistance. These include developing effective diagnostic and prognostic biomarkers for these diseases, studying signaling mechanistic studies, identifying novel therapeutic targets and methods to treat them. Several mouse models have been established or under development to address mechanisms underlying tumor initiation, progression, and metastasis.
Our current research focuses: 1) investigate the role and signaling mechanisms of LPA and their receptors in ovarian and other cancers using both in vitro and in vivo studies; 2) study cancer stem cells; and 3) identify novel and efficacious ovarian cancer treatment targets.
Read more about the Yan Xu Lab.
Tumor metastasis and microenvironment
Mouse models of ovarian cancer
Anoikis-resistance in ovarian cancer
Role of lysophospholipids in ovarian cancer
Development of diagnostic and prognostic markers for ovarian and other cancers
G protein coupled receptors for bioactive lysophospholipids and their signaling pathways
Qipeng Fan (Research Associate)