Michael J. Ferguson, MD

Bio

Dr. Michael Ferguson is an Assistant Professor of Pediatrics and Medical Director of the Pediatric Cancer Precision Genomics Program. He received his medical degree from Indiana University and completed Residency and Fellowship at Riley Hospital for Children, while also obtaining his master’s degree in Clinical Investigation. His research is currently focused on finding new agents for the treatment of relapsed sarcomas (specifically rhabdomyosarcoma, osteosarcoma, and Ewings sarcoma).

Key Publications

Marshall M, Ivanovich J, Schmitt M, Helvie A, Langsford L, Casterline J, Ferguson M. Pediatric Precision Oncology: "Better Three Hours Too Soon Than a Minute Too Late". Front Oncol. 2023 Oct 30;13:1279953

Pandya PH, Jannu AJ, Bijangi-Vishehsaraei K, Dobrota E, Bailey BJ, Barghi F, Shannon HE, Riyahi N, Damayanti NP, Young C, Malko R, Justice R, Albright E, Sandusky GE, Wurtz LD, Collier CD, Marshall MS, Gallagher RI, Wulfkuhle JD, Petricoin EF, Coy K, Trowbridge M, Sinn Al, Renbarger JL, Ferguson MJ, Huang K, Zhang J, Saadatzadeh MR, Pollok KE. Integrative Multi-OMICs Identifies Therapeutic Response Biomarkers and Confirms Fidelity of Clinically Annotated, Serially Passaged Patient-Derived Xenografts Established from Primary and metastatic Pediatric AYA Solid Tumors. Cancers. 2023; 15(1):259

Snyder BM, Lion AH, Helvie AE, Marshall MS, Ferguson MJ. Targeted Treatment of Refractory PNET Arising From An Immature Teratoma with Crizotinib Leading to a Sustained Response. Clin Case Rep. 2023 Jan 3;11(1):e6779.

Barghi F, Shannon HE, Saadatzadeh MR, Bailey BJ, Riyahi N, Bijangi-Vishehsaraei K, Just M, Ferguson MJ, Pandya PH, Pollok KE. Precision Medicine Highlights Dysregulation of the CDK4/6 Cell Cycle Regulatory Pathway in Pediatric, Adolescents and Young Adult Sarcomas. Cancers. 2022 Jul25;14(15):3611

Ferguson MJ, Ivanovich J, Stansell P, Vik TA, Helvie, AE, Schmitt MR, Schultz KA, Dehner LP, Renbarger JL, Marshall MS.  Previously unreported somatic variants in two patients with pleuropulmonary blastoma with metastatic brain recurrence. Pediatr Blood Cancer. 2021 May;68(5):e28825

Pandya PH, Cheng L, Saadatzadeh MR, Bijangi-Vishehsaraei K, Tang S, Sinn AL, Trowbridge MA, Coy KL, Bailey BJ, Young CN, Ding J, Dobrota EA, Dyer S, Elmi A, Thompson Q, Barghi F, Shultz J, Albright EA, Shannon HE, Murray ME, Marshall MS, Ferguson MJ, Bertrand TE, Wurtz LD, Batra S, Li L, Renbarger JL, Pollok KE.  Systems Biology Approach Identifies Prognostic Signatures of Poor Overall Survival and Guides the Prioritization of Novel BET-CHK1 Combination Therapy for Osteosarcoma. Cancers (Basel). 2020 Aug 26;12(9):2426.

Tramontana TF, Marshall MS, Helvie AE, Schmitt MR, Ivanovich J, Carter JL, Renbarger JL, Ferguson MJ. Sustained Complete Response to Palbociclib in a Refractory Pediatric Sarcoma with BCOR-CCNB3 Fusion and Germline CDKN2A Variant. JCO Precision Oncology. 2020 Apr 30;4

Helm BR, Zhan X, Pandya PH, Murray ME, Pollok KE, Renbarger JL, Ferguson MJ, Han Z, Ni D, Zhang J, Huang K. Gene Co-expression Networks Restructured Gen Fusion in Rhabdomyosarcoma Cancers. Genes (Basel). 2019 Aug 30;10(9):665.

Cheng L, Pandya PH, Liu E, Chandra p, Wang L, Murray ME, Carter J, Ferguson M, Saadatzadeh MR, Bijangi-Visheshsaraei K, Marshall M, Li L, Pollok KE, Renbarger JL. Integration of genomic copy number variations and chemotherapy-response biomarkers in pediatric sarcomas. BMC Med Genoics. 2019 Jan 31;12(Suppl 1):23

Därr R, Nambuba J, Del Rivero J, Janssen I, Merino M, Todorovic M, Balint B, Jochmanova I, Prchal JT, Lechan RM, Tischler AS, Popovic V, Miljic D, Adams KT, Prall FR, Ling A, Golomb MR, Ferguson M, Nilubol N, Chen CC, Chew E, Taïeb D, Stratakis CA, Fojo T, Yang C, Kebebew E, Zhuang Z, Pacak K. Novel insights into the polycythemia-paraganglioma-somatostatinoma syndrome. Endocr Relat Cancer. 2016 Dec;23(12):899-908. Epub 2016 Sep 27.

Hanemann CO, Blakeley JO, Nunes FP, Robertson K, Stemmer-Rachamimov A, Mautner V, Kurtz A, Ferguson M, Widemann BC, Evans DG, Ferner R, Carroll SL, Korf B, Wolkenstein P, Knight P, Plotkin SR; REiNS International Collaboration. Current status and recommendations for biomarkers and biobanking in neurofibromatosis. Neurology. 2016 Aug 16;87(7 Suppl 1):S40-8

Ferguson MJ, Rhodes, SJ, Jiang L, Li X, Yuan J, Yang X, Zhang S, Vakili ST, Territo P, Hutchins GD, Yang FC, Clapp DW, Chen S. Preclinical Evidence for the Use of Sunitinib Malate in the Treatment of Plexiform Neurofibromas. Pediatric Blood Cancer. 2016 Feb;63(2):206-13.

Ferguson MJ, Hingorani P, Gupta AA. Emerging Molecular-Targeted Therapies in Early-Phase Clinical Trials and Preclinical Models. What’s New and Improved in the Care of Children with Rhabdomyosarcoma? ASCO 2013. Educational Book 420-424

Egbelakin A, Ferguson MJ, Macgill EA, Lehmann AS, Topletz AR, Quinney SK, Li L, McCammack KC, Hall SD, Renbarger JL. Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2011 Mar;56(3): 361-7