17300-Jacob, Seethal

Seethal A. Jacob, MD, MS, MS, FAAP

Assistant Professor of Pediatrics

Phone 317-278-9662
705 Riley Hospital Drive
ROC 4340

Indianapolis, IN 46202
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Dr. Seethal Jacob is an Assistant Professor of Pediatrics.  She graduated from Wright State Boonshoft School of Medicine in 2009 and completed her pediatric residency and chief residency at Indiana University School of Medicine.  She went on to complete a fellowship in Pediatric Hematology-Oncology, as well as a Masters in Clinical Research at the University of Pittsburgh, where she began researching the genetic association of sickle cell disease and its various complications.  After fellowship, she returned to Indiana University/Riley Hospital for Children as part of the Pediatric and Adolescent Comparative Effectiveness Research (PACER) group and Director of the Comprehensive Pediatric Sickle Cell Program at Riley.  Her research focuses on developing and evaluating interventions, such as telehealth, to improve access to and the quality of care for children living with sickle cell disease.

Key Publications


Jacob SA, Novelli EM, Isenberg JS, Garrett ME, Chu Y, Soldano K, Ataga KI, Telen MJ, Ashley-Koch A, Gladwin MT, et al. Thrombospondin-1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia. Am J Hematol. 2017 Mar;92(3):E31-E34. doi: 10.1002/ajh.24635




Jacob SA, Shaw PH. No improvement in clinical trial enrollment for adolescents and young adults with cancer at a children's hospital. Pediatr Blood Cancer. 2017 May 16. doi: 10.1002/pbc.26638. 


Titles & Appointments

  • Assistant Professor of Pediatrics
  • Education
    2016 MS University of Pittsburgh
    2015 FEL Pediatric Hematology/Oncology Fellowship, Children's Hospital of Pittsburgh
    2012 RES Pediatric Residency, Indiana University School of Medicine
    2009 MD Wright State University
    2005 BS University of Notre Dame
  • Research


    Dr. Jacob’s primary area of research is focused on the use of telemedicine as a means of improving access to care for children in medically underserved areas.  Additionally, she has received state funding for establishment of a formal transition program from adolescents with sickle cell disease, as well as serves on a collaborative state grant that implements a community educational program for parents of young children with sickle cell disease as well as adolescents.


  • Professional Organizations
    American Society of Hematology
    American Society of Pediatric Hematology/Oncology
    Children's Oncology Group
  • Board Certifications
    American Board of Pediatrics - Pediatrics
  • Clinical Interests


    Dr. Jacob cares for a variety of patients with blood disorders, but her primary area of interest is in caring for patients with sickle cell disease as part of Riley’s Comprehensive Sickle Cell Program.  Other areas of interest include red cell disorders, cytopenias, health care policy, and health care access.


  • Awards
    Desc: Trustee Teaching Award
    Scope: University
    Date: 2021-05-01
    Org: Indiana University School of Medicine
    Desc: Gold Humanism Honor Society
    Scope: University
    Date: 2008-01-01

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