16381-Markel, Troy

Troy A. Markel, MD

Associate Professor of Surgery

RI 2500
Indianapolis, IN


Dr. Troy Markel is an Associate Professor of Surgery at the IU School of Medicine and Director of Resident Research. He is a native of Pennsylvania and attended the University of Delaware for his undergraduate education. He obtained a B.A. in Biology and minored in chemistry and psychology. He then attended Penn State University College of Medicine in Hershey, Pennsylvania for his medical training. Following medical school, he attended IU School of Medicine for his general surgery residency and pediatric surgery fellowship. He has an interest in basic science research and has a laboratory dedicated to stem cell biology and its applications for treating necrotizing enterocolitis. His clinical interests include neonatal surgery, short bowel syndrome, oncology, chest wall reconstruction, and trauma. Outside of medicine, he enjoys music and attending concerts at local music venues. He has played percussion for over 20 years and enjoys playing drums with his friends and family.

Key Publications

1.    Markel TA, Weil BR, Hermann JL, Abarbanell AM, Meldrum DR. Mesenchymal Stem Cells Enhance the Viability and Proliferation of Human Fetal Intestinal Epithelial Cells Following Hypoxic Injury Via Paracrine Mechanisms. Surgery. 2009; 146(2): 190-7. PMID:19628073


2.    Wang Y, Weil BR, Herrmann JL, Abarbannell AM, Tan J, Markel TA, Kelly M, Meldrum DR. MEK, P38 and PI3K Mediate Novel Cross Talk Between EGFR and TNFR in Enhancing EGF Production from Human Mesenchymal Stem Cells. AJP-Cell Phys. 2009; 297(5): C1284-93. PMID:19692652


3.    Markel TA, Ball CG, Hayward TZ.  Acute aortic rupture after a trans-spinal gunshot injury
J Trauma. 2011; 70(2):522. PMID:21307758


4.    Markel TA, Wanner MR, Billmire DF.  Gastric Pneumatosis Secondary to Pyloric Stenosis. J Peds Surg. 2013; 48(3): 655-7. PMID:23480927


5.    Markel TA, Lin J, Fan R, Billmire DF.  Bronchogenic/Foregut cyst of the ileal mesentery in a child mimicking ovarian mass. Fet & Ped Pathol, 2013; 32(5): 357-61. PMID:23438792


6.    Graham KA, Laituri CA, Markel TA, Ladd AP.  A Review of Postoperative Feeding Regimens in Infantile Hypertrophic Pyloric Stenosis. J Peds Surg, 2013; 48(10):2175-79. PMID:24094977


7.    Markel TA, Engelstad H, Poindexter BP. Predicting Disease Severity of Necrotizing Enterocolitis: How to Identify Infants for Future Novel Therapies. J Clin Neonatol. 2014; 3(1): 1-9. PMID:24741531 *


8.    Savoie KB, Huang EY, Aziz SK, Blakely ML, Dassinger S, Dorale AR, Duggan EM, Harting MT, Markel TA, Moore-Olufemi SD, Shah SR, St. Peter SD, Tsao K, Wyrick DL, Williams RF. Improving Gastroschesis Outcomes: Does Birthplace Matter? J. Ped Surg. 2014; 49(12): 1771-5. PMID:25487481 *


9.    Crafts TD, Jensen AR, Blocher-Smith EC, Markel TA. Vascular Endothelial Growth Factor: Therapeutic Possibilities and Challenges for the Treatment of Ischemia. Cytokine. 2015; 71(2):385-93. PMID:25240960 *


10.  Markel TA, Rescorla FJ. A Survey of the Pediatric Surgery Program Directors: Optimizing Resident Research to Make Pediatric Surgery Training More Efficient. J Ped Surg. 2015; 50(6): 1053-7. PMID:25805008 *


11.  Markel TA, Proctor C, Ying J, Winchester PD. Environmental Pesticides Increase the Risk of Developing Hypertrophic Pyloric Stenosis. J Ped Surg. 2015; 50(8): 1283-8. PMID:25783294 *


12.  Markel TA, Crafts TD, Jensen AR, Hunsberger EB, Yoder MC. Human Mesenchymal Stem Cells Decrease Mortality Following Intestinal Ischemia and Reperfusion Injury. J Surg Res. 2015; 199(1):56-66. PMID:26219205 *


13.  Crafts TD, Hunsberger EB, Jensen AR, Rescorla FJ, Yoder MC, Markel TA. Direct Peritoneal Resuscitation Improves Survival and Decreases Inflammation Following Intestinal Ischemia and Reperfusion Injury. J Surg Res. 2015; 199(2):428-34. PMID: 26169030 *


14.  Peters LE, Ladd AP, Markel TA. Obstructive Choledocholithiasis Requiring Intervention in a Three Week Old Neonate: A Case Report and Review of the Literature. J Ped Surg Case Rep. 2016; 4(1):13-16. *


15.  Jensen AR, Doster DL, Hunsberger EB, Manning MM, Stokes SM, March KL, Yoder MC, Markel TA.  Human Adipose Stromal Cells Increase Survival and Mesenteric Perfusion Following Intestinal Ischemia. Shock. 2016; 46(1):75-82. PMID: 26796571 *


16.  Batra S, Martin SC, Nassiri M, Qureshi A, Markel TA. Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia—A rare presentation. Case Reports in Oncological  Med, 2016; 2016(Article ID 3179147): 5 pages. PMID: 27429816*


17.  Markel, TA, West KW. Conservative Management of Peritoneal Dialysis Catheters That Erode Into Bowel: A Pediatric Case Series and Review of the Literature. Peritoneal Dialysis International, 2016; 11-12; 36(6):680-84 PMID: 27903851. *


18.  Jensen AR, Manning MM, Khaneki S, Drucker NA, Markel TA. Harvest Tissue Source Does Not Alter the Protective Power of Stromal Cell Therapy Following Intestinal Ischemia and Reperfusion Injury. J Surg Res. 2016; 204(2):361-70. PMID: 27565072*


19.  Markel TA, Scott MR, Stokes SM, Ladd AP. A Randomized Trial To Assess Advancement of Enteral Feedings Following Surgery For Hypertrophic Pyloric Stenosis. J Ped Surg, 2016; 52(4):534-39. PMID: 27829521.


20.  Doster DL, Jensen AR, Khaneki S, Markel TA. Mesenchymal Stromal Cell Therapy for the Treatment of Intestinal Ischemia: Defining the Optimal Cell Line for Maximum Therapeutic Benefit. Cytotherapy, 2016; 18(12): 1457-70. PMID: 27745788*


21.  Gormley T, Markel TA, Jones H, Wagner J, Greely D, Ostojic J, Abkowitz M, Clarke JH.  Methodology for Analyzing Environmental Quality Indicators (EQIs) in a Dynamic Operating Room Environment. Am J Inf Cont. 2016; 45(4): 354-59. PMID 28012705*


22.  Markel TA, Valsangkar NP, Bell TM, Kiel BA, Zimmers TA, Koniaris LG. The Surgeon Scientist: A Comparison of Academic Productivity Between Pediatric and General Surgeons. J Ped Surg. 2016, In press. PMID 28017413*


23.  Jensen AR, Drucker NA, Khaneki S, Ferkowicz MJ, Markel TA. Hydrogen Sulfide Improves Intestinal Recovery Following Ischemia by Endothelial Nitric Oxide Dependent Mechanisms. AJP: GI and Liver Phys. 2017, 312(5):G450-56. PMID 28280145*


24.  Jensen AR, Drucker NA, Khaneki S, Ferkowicz MJ, Olson KR, Yoder MC, Markel TA. Hydrogen Sulfide: A potential Novel Therapy for the Treatment of Ichemia. Shock, 2017, In press. PMID 28498298*


25.  Khaneki S, Jensen AR, Drucker NA, Markel TA. Direct Peritoneal Resuscitation Improves Mesenteric Perfusion by Nitric Oxide Dependent Pathways. J Surg Res. 2017, 213:274-80. PMID 28601326*

Titles & Appointments

  • Associate Professor of Surgery
  • Education
    2004 MD Pennsylvania State University
    2000 BA University of Delaware
  • Research

    Dr. Markel is a surgeon-scientist with interests in stem cell therapy for intestinal ischemia and necrotizing enterocolitis.  NEC affects 15% of the 450,000 premature infants born annually and often necessitates the surgical resection of necrotic bowel.  Many infants are left with suboptimal lengths of the intestine to functionally absorb oral nutrition.  Dr. Markel hopes to begin clinical trials with stem cells for NEC in the very near future.

  • Professional Organizations
    Alpha Omega Alpha
    American Academy of Pediatrics
    American College of Surgeons
    Association of Academic Surgeons
    NEC Society
    Shock Society
  • Board Certifications
    American Board of Surgery - Pediatric Surgery
    American Board of Surgery - Surgery*
  • Clinical Interests

    Necrotizing enterocolitis, neonatal nutrition, neonatal surgery, oncology, chest wall reconstruction, and trauma. 

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