15037-Klemsz, Michael

Michael J. Klemsz, PhD

Associate Professor of Microbiology & Immunology

MS 420
635 Barnhill Drive

Indianapolis, IN
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Key Publications

Klemsz, M.J., McKercher, S.R., Celada, A., Van Beveren, C. and Maki, R.A. (1990) The macrophage and B cell specific transcription factor PU.1 is related to the ets oncogene. Cell 61:113-124.

Hromas, R. and Klemsz, M. (1994) The ETS oncogene family in development, proliferation and neoplasia. Int. J. Hemat. 59:257-265.

Cramer, L.A., Nelson, S.L. and Klemsz, M.J. (2000) Synergistic induction of the Tap-1 gene by IFN-g and LPS in macrophages is regulated by STAT 1. J. Immunol. 165:3190-3197.

Laribee, R.N. and Klemsz, M.J. (2001) Loss of PU.1 expression following inhibition of histone deacetylases. J. Immunol, 167:5160-5166.

Cecil, A.A. and Klemsz, M.J.  (2004) p38 activation through Toll receptors modulates IFN-g induced expression of the Tap-1 gene only in macrophages. J. Leukoc. Biol. 75:560-568.

Laribee, R.N. and Klemsz, M.J. (2005) Histone H4 HDAC activity is necessary for expression of the PU.1 gene. Biochimica et Biophysica Acta. 1730:226-234.

Chang, H-C., Zhang, S., Thieu, V.T., Slee, R.B., Bruns, H.A., Laribee, R.N., Klemsz, M.J. and Kaplan, M.H. (2005) PU.1 expression delineates heterogeneity in primary Th2 cells. Immunity 22:1-11.

Wilkes, D.S., Chew, T., Flaherty, K.R., Frye, S., Gibson, K.F., Kaminski, N., Klemsz, M.J., Lange, W., Noth, I., and Rothhaar, K. (2015) Oral Immunotherapy with Type V Collagen in Idiopathic Pulmonary Fibrosis. Eur. Respir. J. 45:1393-1402. 


Titles & Appointments

  • Associate Professor of Microbiology & Immunology
  • Statewide Course Director-Host Defense
  • Education
    1987 PhD University of Colorado Health Sciences Center
    1982 BA University of Colorado
  • Research

    My laboratory has two main areas of focus. In the first, we are studying how signaling in macrophages changes the expression of the transcription factor, PU.1. The goal is to determine if small difference in PU.1 protein expression is important for the function of these cells in either inflammatory responses or wound healing. These studies include the role of chromatin structure in respponding to a variety of signals resulting in changes in the expression of the PU.1 gene. A second area of research involves developing novel immunotherapy molecules that would be used to generate tolerance responses in patients with different autoimmune diseases. 

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