The long term goal of my research is to elucidate molecular mechanisms which are responsible for the neuronal death and inflammation in neurodegenerative/neuronal injury disorders including Alzheimer's disease, Parkinson's disease, stroke, and Amyotrophic Lateral Sclerosis. Additionally, I am also interested in hypertension and adipose stem cells. The research can provide valuable information which may lead to the development of preventive and therapeutic approaches to these disorders. In particular, my interests include: 1) studying pathogenic mechanisms underlying neurodegenerative disorders and hypertension; 2) Using animal, adipose stem cells, and cellular models for the mechanistic and therapeutic studies; 3) drug and therapeutic development.
The laboratory is a molecular cell biology laboratory. Most molecular and cell biology techniques performed in this laboratory include: PCR, genotyping, promoter study, cloning and expression, Southern, Northern and Western blotting, gel-shift assay, protein purification, immunocytochemistry, image analysis, ELISA, primary brain cell cultures, GLP toxicity study, animal surgery, as well as generation and characterization of transgenic mice. Broad collaborations with clinical and basic research laboratories have been internationally established.