Yansheng Du, PhD

The long term goal of my research is to elucidate molecular mechanisms which are responsible for the neuronal death and inflammation in neurodegenerative/neuronal injury disorders including Alzheimer's disease, Parkinson's disease, stroke, and Amyotrophic Lateral Sclerosis. Additionally, I am also interested in hypertension and adipose stem cells. The research can provide valuable information which may lead to the development of preventive and therapeutic approaches to these disorders. In particular, my interests include: 1) studying pathogenic mechanisms underlying neurodegenerative disorders and hypertension; 2) Using animal, adipose stem cells, and cellular models for the mechanistic and therapeutic studies; 3) drug and therapeutic development.

The laboratory is a molecular cell biology laboratory. Most molecular and cell biology techniques performed in this laboratory include: PCR, genotyping, promoter study, cloning and expression, Southern, Northern and Western blotting, gel-shift assay, protein purification, immunocytochemistry, image analysis, ELISA, primary brain cell cultures, GLP toxicity study, animal surgery, as well as generation and characterization of transgenic mice. Broad collaborations with clinical and basic research laboratories have been internationally established.

Sevoflurane preconditioning ameliorates traumatic spinal cord injury through caveolin-3-dependent cyclooxygenase-2 inhibition.
Wu W; Wei N; Wang L; Kong D; Shao G; Qin Y; Wang L; Du Y; Oncotarget 2017 Sep 21

Salt-dependent Blood Pressure in Human Aldosterone Synthase-Transgenic Mice.
Gu H; Ma Z; Wang J; Zhu T; Du N; Shatara A; Yi X; Kowala MC; Du Y; Scientific reports 2017 Mar 28

Oxaloacetate and adipose stromal cells-conditional medium synergistically protected potassium/serum deprivation-induced neuronal apoptosis.
Liu Q; Zhao G; Zhou C; Farlow MR; Du Y; Xu G; Gu H; Brain research bulletin 2016 Nov 2

GDNF secreted from adipose-derived stem cells stimulates VEGF-independent angiogenesis.
Zhong Z; Gu H; Peng J; Wang W; Johnstone BH; March KL; Farlow MR; Du Y; Oncotarget 2016 May 6

Metformin prevents cerebellar granule neurons against glutamate-induced neurotoxicity.
Zhou C; Sun R; Zhuang S; Sun C; Jiang Y; Cui Y; Li S; Xiao Y; Du Y; Gu H; Liu Q; Brain research bulletin 2016 Feb 11

High glucose-induced Matrilin-2 expression in mouse mesangial cells was mediated by transforming growth factor beta 1 (TGF-ß1).
Zhang S; Zhang M; Huang H; Zhou S; Du Y; Yi X; Luo J; Biochemical and biophysical research communications 2016 Apr 20

Adipose-derived Stem Cell Conditioned Media Extends Survival time of a mouse model of Amyotrophic Lateral Sclerosis.
Fontanilla CV; Gu H; Liu Q; Zhu TZ; Zhou C; Johnstone BH; March KL; Pascuzzi RM; Farlow MR; Du Y; Scientific reports 2015 Nov 20

TIMP1 in conditioned media of human adipose stromal cells protects neurons against oxygen-glucose deprivation injury.
Du S; Mao G; Zhu T; Luan Z; Du Y; Gu H; Neuroscience letters 2014 Oct 2

Adipose stem cells-conditioned medium blocks 6-hydroxydopamine-induced neurotoxicity via the IGF-1/PI3K/AKT pathway.
Wang X; Zhao Z; Gong J; Zhou S; Peng H; Shatara A; Zhu TZ; Meltzer R; Du Y; Gu H; Neuroscience letters 2014 Aug 23

The role of choroid plexus in IVIG-induced beta-amyloid clearance.
Gu H; Zhong Z; Jiang W; Du E; Dodel R; Farlow MR; Zheng W; Du Y; Neuroscience 2014 Apr 16