Bart A. Pederson, PhD

Bio

Bartholomew Pederson received his PhD at the University of North Dakota School of Medicine and Health Sciences where he investigated the regulation of glucose-6-phosphatase in liver. He completed a postdoctoral fellowship at Indiana University School of Medicine-Indianapolis where he examined glycogen synthase regulation in yeast and the role of muscle glycogen synthase in transgenic and knockout mouse models. Dr. Pederson’s most recent research uses genetically modified mouse models to study the role of glycogen in health and disease.

Key Publications

Pederson, B.A. “Mammalian Glycogen Metabolism: Enzymology, Regulation, and Animal Models of Dysregulated Glycogen Metabolism”. Enzymology of Complex Alpha-glucans, edited by Felix Nitschke, CRC Press, 2021, pp. 83-136. Abstract

Pederson, B.A. (2019) “Structure and regulation of glycogen synthase in the brain.” Adv Neurobiol, 23: 83-123. Abstract

Chown, E.E., Wang, P., Zhao, X., Crowder, J.J., Strober, J.W., Sullivan, M.A., Xue, Y., Bennett, C.S.,Perri, A. M., Evers, B.M, Roach, P. J., Depaoli-Roach, A. A., Akman, H. O., Pederson, B. A., and Minassian, B.A (2020). "GYS1 or PPP1R3C deficiency rescues murine adult polyglucosan body disease." Ann Clin Transl Neurol. 7, 2186-2198. Abstract

Mayeuf-Louchart, A.,  Lancel, S., Sebti, Y., Pourcet, B., Loyens, A., Delhaye, S., Duhem,C., Beauchamp, J., Ferri, L., Thorel, Q., Boulinguiez, A., Zecchin, M., Dubois-Chevalier, J., Eeckhoute, J., Vaughn, L.T., Roach, P.J., Dani, C., Pederson, B.A., Vincent, S.D., Staels, B., and Duez, H. (2019) Glycogen dynamics drives lipid droplet biogenesis during brown adipocyte differentiation. Cell Reports 29, 1410-1418. Abstract

Pederson, B. A., Turnbull, J., Epp, J. R., Weaver, S. A., Zhao, X., Pencea, N., Roach, P. J., Frankland, P. W., Ackerley, C. A. and Minassian, B. A. (2013), Inhibiting glycogen synthesis prevents lafora disease in a mouse model. Annals of Neurology, 74: 297–300. Abstract | Full Text

Canada, S.E., Weaver, S.A., Sharpe, S.N, and Pederson, B.A. (2011) Brain glycogen supercompensation in the mouse after recovery from insulin-induced hypoglycemia. J. Neurosci. Res. 89, 585-591. Abstract | Full Text

Savage, D.B., Zhai, L., Ravikumar, B., Choi, C.S., Snaar, JEM., Medina-Gomez, G. Kim, S., McGuire, A.C., Wou, S-E., Bock, C.B., Evans, R.M., Vidal-Puig, A., Barroso, I., Shulman, G.U., Karpe, F., Taylor, R., Pederson, B.A., Roach, P.J., O'Rahilly, S., DePaoli-Roach, A.A. (2008) A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice. PLOS-Medicine. 5, e2. PMC2214798 | Abstract | Full Text | Supplementary Material | Correction

Pederson, B.A., Schroeder, J.M., Parker, G.E., Smith, M.W., Depaoli-Roach, A.A., Roach, P.J. (2005) Glucose metabolism in mice lacking muscle glycogen synthase. Diabetes ,54, 3466-3473. Abstract | Full Text

Pederson, B.A., Cope, C.R., Irimia, J.M., Schroeder, J.M., Thurberg, B.L., Depaoli-Roach, A.A., Roach, P.J. (2005) Mice with elevated muscle glycogen stores do not have improved exercise performance. Biochem. Biophys. Res. Commun. 331, 491-496. Abstract

Pederson, B.A., Cope, C.R., Schroeder, J.M., Smith, M.W., Irimia, J.M., Thurberg, B.L., Depaoli-Roach, A.A., Roach, P.J. (2005) Exercise capacity of mice genetically lacking muscle glycogen synthase: In mice, muscle glycogen is not essential for exercise. J. Biol. Chem. 280, 17260-17265. Abstract | Full Text | Full Text (PDF)

Pederson, B.A., Chen, H., Schroeder, J.M., Shou, W., Depaoli-Roach, A.A., Roach, P.J. (2004) Abnormal cardiac development in the absence of heart glycogen. Mol.Cell. Biol. 24, 7179-7187. Abstract | Full Text | Full Text (PDF)