Faculty

Chao-Hung Lee

Address
Medical Research & Library Building IB424A
975 W. Walnut St.

Indianapolis, IN 46202

Bio

Teaching: Applied Molecular Biology (course #G890)

1.     Lee, C. H., J. J. Lu, M. S. Bartlett, M. M. Durkin, T. H. Liu, J. Wang, B. Jiang, and J. W. Smith.  1993.  Nucleotide sequence variation in Pneumocystis carinii strains that infect humans.  J. Clin. Microbiol.  31:754-757.

2.     Lee, C. H., N. L. Bauer, M. M. Shaw, M. M. Durkin, M. S. Bartlett, S. F. Queener, and J. W. Smith.  1993.  Proliferation of rat Pneumocystis carinii on cells sheeted on microcarrier beads in spinner flasks.  J. Clin. Microbiol. 31:1659-1662.

3.     Bartlett, M. S., T. D. Edlind, C. H. Lee, R. Dean, S. F. Queener, M. M. Shaw, and J. W. Smith.  1994.  Albendazole inhibits Pneumocystis carinii proliferation in inoculated immunosuppressed mice.  Antimicrob. Ag. Chemother.  38:1834-1837.

4.     Lu, J. J., M. S. Bartlett, M. M. Shaw, J. W. Smith, M. Ortiz-Rivera, M. J. Leibowitz, and C. H. Lee.  1994.  Typing of Pneumocystis carinii strains that infect humans based on nucleotide sequence variations of internal transcribed spacers of rRNA genes. J. Clin. Microbiol.  32:2904-2912.

5.     Lu, J. J.,  C. H. Chen, M. S. Bartlett, J. W. Smith, and C. H. Lee.  1995.  Comparison of Six Different PCR Methods for the Detection of Pneumocystis carinii. J. Clin. Microbiol.  33:2785-2788.

6.     Lu, J. J.,  M. S. Bartlett, J. W. Smith, and C. H. Lee.  1995.  Typing of Pneumocystis carinii strains with type-specific oligonucleotide probes derived from nucleotide sequences of internal transcribed spacers of rRNA genes. J. Clin. Microbiol.  33:2973-2977.

7.     Bartlett, M. S., S. H. Vermund, R. Jacobs, P. Durant, M. M. Shaw, J. W. Smith, X. Tang, J. J. Lu, B. Li, S. Jin, and C. H. Lee.  1997.  Detection of Pneumocystis carinii DNA in air samples: Likely environmental risk to susceptible persons.  J. Clin. Microbiol. 35:2511-2513.

8.     Tang, X., M. S. Bartlett, J. W. Smith, J. J. Lu, and C. H. Lee.  1998.  Determination of copy number of rRNA genes in Pneumocystis carinii f. sp. hominis.  J. Clin. Microbiol.  36:2491-2494.

9.     Lee, C. H., X. Tang, S. Jin, B. Li, M. S. Bartlett, B. Lundgren, J. Helweg-Larsen, M. Olsson, S. B. Lucas, P. Roux, A. Cargnel, C. Atzori, O. Matos, and J. W. Smith.  1998.  Update on Pneumocystis carinii f. sp. hominis typing based on nucleotide sequence variations in the internal transcribed spacer regions of rRNA genes.  J. Clin. Microbiol.  36:734-741.

10.  Lee, C. H., M. E. Lasbury, J. R. Paulsrud, N. L. Bauer, S. L. Brady, G. A. Weinberg, P. J. Durant, M. S. Bartlett, and J. W. Smith.  2000.  Characterization of an Immunogenic Histidine and Aspartic Acid Rich Protein and the Gene Encoding the Protein from Pneumocystis carinii.  J. Eukaryot. Microbiol. 47:581-584.

11.  Tang, X., M. E. Lasbury, D. D. Davidson, M. S. Bartlett, J. W. Smith, and C. H. Lee. 2000. Down-regulation of GATA-2 transcription factor during Pneumocystis carinii infection. Infect.  Immun. 68:4720-4724.

12.  Lasbury, M.E., X. Tang, P.J. Durant, and C.H. Lee. 2003. Effect of transcription factor GATA-2 on phagocytic activity of alveolar macrophages from Pneumocystis carinii-infected hosts. Infect. & Immun. 71(9):4943-4952.

13.  Lasbury, M.E., P.J. Durant, and C.H. Lee. 2003.  Correlation of Pneumocystis carinii burden and alveolar macrophage number during infection and recovery. Clin. Diag. Lab. Immunol.  10(2):293-302.

14.  Lasbury, M.E., P. Lin, D. Tschang, P.J. Durant, and C.H. Lee. 2004. Effect of bronchoalveolar lavage fluids from Pneumocystis carinii-infected hosts on phagocytic activity of alveolar macrophages. Infect. Immun. 72:2140-2147.

15.  Zhang, C., S.-H. Wang, M.E. Lasbury, D. Tschang, C.P. Liao, P.J. Durant, and C. H. Lee. 2006. Toll-Like receptor 2 mediates alveolar macrophage response to Pneumocystis murina. Infect. Immun. 74:1857-1864.           

16.  Lasbury, M. E., P. J. Durant, C. A. Ray, D. Tschang, R. Schwendener, and C. H. Lee. 2006. Suppression of alveolar macrophage apoptosis prolongs survival of rats and mice with Pneumocystis pneumonia. J. Immunol. 176:6443-6453.

17.  Lasbury, M. E., S. Merali, P. J. Durant, D. Tschang, C. A. Ray, and C. H. Lee. 2007. Polyamine-mediated induction of alveolar macrophage apoptosis during Pneumocystis pneumonia. J. Biol. Chem. 282: 11009 - 11020.

18.  Wang, S. H., C. Zhang, M. E. Lasbury, C. P. Liao, P. J. Durant, D. Tschang, and C. H. Lee. 2008. Decreased inflammatory response in Toll-like receptor 2 knockout mice is associated with exacerbated Pneumocystis pneumonia . Microbes and Infection 10:334-341.

19.  Liao, C.-P., M. E. Lasbury, S. H. Wang, C. Zhang, P. J. Durant, Y. Murakami, S. Matsufuji, and C. H. Lee. 2009. Pneumocystis mediates overexpression of antizyme inhibitor resulting in increased polyamine levels and apoptosis in alveolar macrophages. J. Biol. Chem. 284: 8174-8184.

20.  Lasbury, M. E,, P. J. Durant, C. P. Liao, and C H. Lee. 2009. Effects of decreased calmodulin protein 1 on the survival mechanisms of alveolar macrophages during Pneumocystis pneumonia. Infect. Immun. 77: 3344-3354.

21.  Liao, C. P., O. Phanstiel IV, M. E. Lasbury, C. Zhang, S. Shao, P. J. Durant, B. H. Cheng, and C. H. Lee. 2009. Polyamine transport as a target for treatment of Pneumocystis pneumonia. Antimicrob. Ag. Chemother. 53: 5259-5264.

22.  Cheng, B. H., Y. Liu, X. Xuei, C. P. Liao, D. Lu, M. E. Lasbury, P. J. Durant, and C. H. Lee. 2010. Microarray studies on effects of Pneumocystis carinii infection on global gene expression in alveolar macrophages. BMC-Microbiology 10:103.

23.  Zhang, C., S. H. Wang, C. P. Liao, S. Shao, M. E. Lasbury, P. J. Durant, and C. H. Lee.  2010.  Down-regulation of PU.1 leads to decreased expression of dectin-1 in alveolar macrophages during Pneumocystis pneumonia.  Infect. Immun. 78: 1058-1065.

24.  Lasbury, M. E., C. P. Liao, C. A. Hage, P. J. Durant, D. Tschang, S. H. Wang, C. Zhang, and C. H. Lee. 2011. Defective nitric oxide production by alveolar macrophages during Pneumocystis pneumonia.  Am. J. Resp. Cell Mol. Biol.  44: 540-547.

25.  Zhang, C., G. S. Lei, S. Shao. H. W. Jung, P. J. Durant, and C. H. Lee. 2012. Accumulation of myeloid-derived suppressor cells in the lungs during Pneumocystis pneumonia. Infect. and Immun. 80(10):3634-3641.

26.  Lei, G. S., C. Zhang, S. Shao. H. W. Jung, P. J. Durant, and C. H. Lee. 2013. All-trans retinoic acid in combination with primaquine clears Pneumocystis infection. PLOS ONE 8(1):e53479.

27.  Esteves F, Lee CH, de Sousa B, Badura R, Seringa M, Fernandes C, Gaspar JF, Antunes F, Matos O. (1-3)-beta-D-glucan in association with lactate dehydrogenase as biomarkers of Pneumocystis pneumonia (PcP) in HIV-infected patients. Eur J Clin Microbiol Infect Dis. 2014 Jul;33(7):1173-80. doi: 10.1007/s10096-014-2054-6. Epub 2014 Feb 3. PubMed PMID: 24487911.

28.  Lei GS, Zhang C, Lee CH. Myeloid-Derived Suppressor Cells Impair Alveolar Macrophages Through PD-1 Receptor Ligation During Pneumocystis Pneumonia. Infect Immun. 2015 Feb;83(2):572-82. doi: 10.1128/IAI.02686-14. Epub 2014 Nov 17.

29.  Zhang C, Lei GS, Lee CH, Hage CA. Evaluation of two new enzyme immunoassay reagents for diagnosis of histoplasmosis in a cohort of clinically characterized patients. Med Mycol. 2015 Nov;53(8):868-73. doi: 10.1093/mmy/myv062. Epub 2015 Sep 2. PubMed PMID: 26337088.

30.  Lei GS, Zhang C, Zimmerman MK, Lee CH. Vitamin D as Supplemental Therapy for Pneumocystis pneumonia. Antimicrob Agents Chemother. 2015 Dec 14. pii: AAC.02607-15. [Epub ahead of print] PubMed PMID: 26666941.

31.  Lei GS, Kline HL, Lee CH, Wilkes DS, Zhang C. Regulation of Collagen V Expression and Epithelial-Mesenchymal Transition by miR-185 and miR-186 during Idiopathic Pulmonary Fibrosis. Am J Pathol. 2016 Sep;186(9):2310-6. doi: 10.1016/j.ajpath.2016.04.015.

Titles & Appointments

  • Professor Emeritus of Pathology & Laboratory Medicine
  • Research

    Pneumocystis jirovecii (previously Pneumocystis carinii) 

  • Awards
    Org: Indiana University School of Medicine
    Desc: In recognition of teaching excellence
    Scope: School
    Date: 1993-05-01

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