14059-Mayo, Lindsey

Lindsey D. Mayo, PhD

Associate Professor of Pediatrics

Indianapolis, IN


Dr. Mayo grew up in Plainfield, Indiana, and 1992  he earned a B.S. from Indiana State University in Life Sciences. He went on to earn his Ph.D. from Wright State University in Biomedical Science in 1997.  His research focus was in Biochemistry and Molecular Biology focused on the regulation of Mdm2 oncogene. 

From 1998-2003, Dr. Mayo did post-doctoral work at Indiana Unversity School of Medicine in the Walther Oncology Center and the Department of Microbiology and Immunology under the direction of Dr. David Donner.  There, he made several seminal discoveries related to angiogenesis, NFkB, Akt signaling pathways, and p53-PTEN pathway. 

In 2003 Dr. Mayo joined the Faculty at Case Western Reserve University, School of Medicine, in the Department of Radiation Oncology, Case Comprehensive Cancer Center as an Assistant Professor. He continued work on Mdm2 and PTEN.  

In 2007, he was recruited to Indiana University School of Medicine, Departments of Pediatrics, Herman B Wells Center for Pediatric Research and Biochemistry and Molecular Biology. At IU (2009-2013) he was the director of the IU Simon Cancer Center summer research program for underrepresented minorities, which provided research opportunities for high school and college students. At IU Dr. Mayo has trained numerous students (undergraduate, pre-doc and post-docs and currently serves as a mentor in the I3 faculty mentoring program IUSM. He currently serves on numerous committees at the university and school level. He also serves on study sections nationally (NIH, DOD and foundations) and internationally. He has continued to make novel discoveries in the area of Mdm2, p53 and PTEN related to the regulation of their respective activity and how that relates to the tumor microenvironment.  

Titles & Appointments

  • Associate Professor of Pediatrics
  • Adjunct Associate Professor of Biochemistry & Molecular Biology
  • Education
    1997 PhD Wright State University
    1992 BS Indiana State University
  • Research

    Current Research Interests: Mdm2 was initially described as an oncogene through its ability to transform cells. Clinically, Mdm2 is not detected in normal tissue but is detectable in 40-80% of various types of late stage cancers (adult and children). It remains unclear whether there are specific transcription factors that are necessary to elevate mdm2 gene expression in response to growth factors and cytokines, which are highly elevated in the tumor microenvironment. In addition, there are major voids in our understanding of how Mdm2 is regulated at the post-translational level to regulate proteins in tumor cells to promote metastasis in response to the growth factors and cytokines in the tumor microenvironment

  • Professional Organizations
    American Association for Cancer Research
    American Association for the Advancement of Science
    American Society for Biochemistry and Molecular Biology
  • Clinical Interests

    Understanding how tumor suppressor and oncogenes become altered to promote tumor metastasize and become resistant to conventional therapy.

  • Awards
    Org: Indiana University School of Medicine
    Desc: Trustee's Teaching Award
    Scope: University
    Date: 2013-01-01
    Org: General Motors Cancer Research Foundation
    Desc: Scholar Award
    Scope: National
    Date: 2004-01-01
    Desc: Scholar-in-Traning Award
    Scope: National
    Date: 2003-04-10
    Org: AACR-Aventis Oncology
    Desc: Scholar-in-Traning Award
    Scope: National
    Date: 2002-02-13

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