Dr. Mayo grew up in Plainfield, Indiana, and 1992 he earned a B.S. from Indiana State University in Life Sciences. He went on to earn his Ph.D. from Wright State University in Biomedical Science in 1997. His research focus was in Biochemistry and Molecular Biology focused on the regulation of Mdm2 oncogene.
From 1998-2003, Dr. Mayo did post-doctoral work at Indiana Unversity School of Medicine in the Walther Oncology Center and the Department of Microbiology and Immunology under the direction of Dr. David Donner. There, he made several seminal discoveries related to angiogenesis, NFkB, Akt signaling pathways, and p53-PTEN pathway.
In 2003 Dr. Mayo joined the Faculty at Case Western Reserve University, School of Medicine, in the Department of Radiation Oncology, Case Comprehensive Cancer Center as an Assistant Professor. He continued work on Mdm2 and PTEN.
In 2007, he was recruited to Indiana University School of Medicine, Departments of Pediatrics, Herman B Wells Center for Pediatric Research and Biochemistry and Molecular Biology. At IU (2009-2013) he was the director of the IU Simon Cancer Center summer research program for underrepresented minorities, which provided research opportunities for high school and college students. At IU Dr. Mayo has trained numerous students (undergraduate, pre-doc and post-docs and currently serves as a mentor in the I3 faculty mentoring program IUSM. He currently serves on numerous committees at the university and school level. He also serves on study sections nationally (NIH, DOD and foundations) and internationally. He has continued to make novel discoveries in the area of Mdm2, p53 and PTEN related to the regulation of their respective activity and how that relates to the tumor microenvironment.