13496-Croop, James

James M. Croop, MD, PhD

Professor Emeritus of Pediatrics

RI 4340
Indianapolis, IN
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Dr. James Croop is a Professor of Pediatrics at Indiana University in the Section of Pediatric Hematology and Oncology. He attended the University of Pennsylvania School of Medicine obtaining both MD and PhD degrees. He did his Pediatric residency at the Children’s Hospital of Philadelphia and his fellowship in Pediatric Hematology/Oncology at Boston Children’s Hospital and the Dana-Farber Cancer Institute. He was a visiting fellow at the Massachusetts's Institute of Technology Cancer Center. Dr. Croop's research included cloning and characterizing the multidrug resistance gene and developing tumor vaccine models in mice to treat leukemia. He has been the principal investigator of clinical gene therapy trials and is currently the institutional principal investigator for the Children’s Oncology Group Phase I Program at Riley Children’s Hospital. Dr. Croop has served as the Research Subject Advocate for the GCRC and is currently the Chair of the Children's Oncology Group Institutional Performance Monitoring Committee. He has been the Chair of the Indiana University Simon Cancer Center Scientific Review Committee since 1999.


Key Publications


Dunussi-Joannopoulos, K., Dranoff, G.,Weinstein, H., Ferrara , J., Bierer, B. E., Croop, J.M. Gene Immunotherapy in murine Acute Myeloid Leukemia: Granulocyte-Macrophage colony-stimulating factor tumor cell vaccines elicit more potent antitumor immunity compare with B7 family and other cytokine vaccines. Blood. 1998; 91:222-230.




Barbarics, E., Kronauge, J.F., Cohen, D., Davison, A., Jones, A.G. Croop, J.M. Characterization of P-glycoprotein transport and inhibition in vivo. 1998; Cancer Res 58:276-282.


Croop J.M., Cooper, R., Seshadri R., Fernandez, C., Graves, V., Kreissman, S., Smith, F.O., Cornetta, K., Williams, D.A., Abonour R. Large Scale Mobilization and Isolation of CD34+ Cells from Normal Donors. Bone Marrow Transplantation. 2000; 26:1271-1279


Croop, J.M., Cooper, R., Fernandez, C., Graves, V., Kreissman S., Hanenberg, H., Smith, F.O., Cornetta K., Williams D.A. Mobilization and Collection of Peripheral Blood CD34+ Cells from Patients with Fanconi Anemia. Blood 2001; 98: 2917-2921




Kumar, M., Vik, T., Johnson, C. Southwood, M.E., Croop, J.M. Treatment, outcome and cost of care in children with idiopathic thrombocytopenic purpura. Am J Hem 2005; 78:181-187.




Cavalier M.E., Davis M.M., Croop J.M. Germline p53 mutation presenting as synchronous tumors. Journal of Pediatric Hematology/Oncology. 2005 27:441-443.




Daw N.C., Furman W.L., Stewart C.F., Iacono L.C., Krailo M., Bernstein M.L., Dancey J.E., Speights R.A., Blaney S.M., Croop J.M., Reaman G.H., Adamson P.C. Phase I and pharmacokinetic study of gefitinib in children with refractory solid tumors: a Children's Oncology Group Study. Journal of Clinical Oncology. 2005 23:6172-6180.




Cornetta K. Croop J. Dropcho E. Abonour R. Kieran MW. Kreissman S. Reeves L. Erickson LC. Williams DA. A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase. Cancer Gene Therapy. 2006 13:886-895.




Mondick J.T., Johnson BM. Haberer L.J., Sale M.E., Adamson P.C., Coté C.J., Croop J.M.,. Russo M.W., Barrett J.S., Hoke J.F. Population pharmacokinetics of intravenous ondansetron in oncology and surgical patients aged 1-48 months. European Journal of Clinical Pharmacology. 2010 66:77-86.




Creary S, Heiny M, Croop J, Fallon R, Vik T, Hulbert M, Knoderer H, Kumar M, Sharathkumar A. Clinical course of postthrombotic syndrome in children with history of venous thromboembolism. Blood Coagul Fibrinolysis. 2012 23:39-44.




Robertson KA, Nalepa G, Yang FC, Bowers DC, Ho CY, Hutchins GD, Croop JM, Vik TA, Denne SC, Parada LF, Hingtgen CM, Walsh LE, Yu M, Pradhan KR, Edwards-Brown MK, Cohen MD, Fletcher JW, Travers JB, Staser KW, Lee MW, Sherman MR, Davis CJ, Miller LC, Ingram DA, Clapp DW. Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial. Lancet Oncol. 2012 13:1218-1224.




Mueller, E.L., Croop, J., Carroll, AE. Fever and neutropenia hospital discharges in children with cancer: A 2012 update. Pediatr Hematol Oncol. 2016 33:39-48.

Titles & Appointments

  • Professor Emeritus of Pediatrics
  • Education
    1986 FEL Pediatric Hematology/Oncology Fellowship, Children's Hospital Medical Center
    1983 RES Pediatric Residency, Children's Hospital of Philadelphia
    1980 PhD University of Pennsylvania
    1980 MD University of Pennsylvania
    1974 BA University of Pennsylvania
  • Research

    Dr. Croop is the institutional principle investigator for the Children's Oncology Group Phase I Program and a number of pharmaceutical company sponsored trials.

  • Board Certifications
    American Board of Pediatrics - Pediatric Hematology-Oncology
    American Board of Pediatrics - Pediatrics
  • Clinical Interests

    Developing new and novel agents for treating children with cancer.



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