13231-Walker, Chandler

Chandler L. Walker, PhD

Associate Professor, School of Dentistry

DS 260A
Indianapolis, IN
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Key Publications

1. Brown BL, Sandelski, MM, Drejet SM, Runge EM, Shipchandler TZ, Jones KJ, Walker CL. (2020) Facial nerve repair utilizing intraoperative repair strategies. Laryngoscope Investig Otolaryngol, 5(3), 552-559; doi.org/10.1002/lio2.411.

2. Wang J, Zuzzio K, and Walker CL. (2019) Systemic dental pulp stem cell secretome therapy in a mouse model of amyotrophic lateral sclerosis. Brain Sci, 9, 165; doi:10.3390/brainsci9070165.

3. Walker CL. (2019) Adipose-derived stem cell conditioned medium for the treatment of amyotrophic lateral sclerosis: pre-clinical evidence and potential for clinical application. Neural Regen Res, (9):1522-1524.

4. Wang J, Fry CME, Walker CL. (2019) Carboxyl-terminal modulator protein regulates Akt signaling during skeletal muscle atrophy in vitro and a mouse model of amyotrophic lateral sclerosis. Sci Reports, 9:3920.

5. Walker CL, Wu XB, Liu, NK Xu XM. (2019) Bisperoxovanadium mediates neuronal protection through inhibition of PTEN and activation of PI3K/AKT-mTOR signaling following traumatic spinal injuries. J Neurotrauma, 2019 Mar 28. doi: 10.1089/neu.2018.6294 (E-pub ahead of print).

6. Walker CL, Fry CME, Wang J, Du X, Zuzzio K, Liu NK, Walker M, Xu XM. (2018) Functional and histological gender comparison of age-matched rats after moderate thoracic contusive spinal cord injury. J Neurotrauma. 36:1-11.

7. Brown BL, Asante T, Welch HR, Sandelski MM, Drejet SM, Shah K, Runge EM, Shipchandler TZ, Jones KJ, Walker CL. (2018) Functional and anatomical outcomes of facial nerve injury with application of polyethylene glycol in a rat model. JAMA Facial Plast Surg. May 17. 2018.

8. Iyer AK, Jones KJ, Sanders VM, Walker CL (2018) Temporospatial analysis and new players in the immunology of Amyotrophic Lateral Sclerosis. Int J Mol Sci. 19(2).

9. Walker CL, Meadows RM, Merfeld-Clauss S, Du Y, March KL, Jones KJ. (2018) Adipose-derived stem cell conditioned medium impacts asymptomatic peripheral neuromuscular denervation in the mutant superoxide dismutase (G93A) transgenic mouse model of amyotrophic lateral sclerosis. Restor Neurol Neurosci. 36(5):621-627.

10. Xu XB, Walker CL, Lu Q, Wu W, Eddelman DB, Parrish JM, Xu XM. (2016) RhoA/Rho Kinase Mediates Neuronal Death Through Regulating cPLA2 Activation. Molecular Neurobiology, doi:10.1007/s12035-016-0187-6.

11. Walker CL, Zhang YP, Liu, Y, Li, YP, Walker, MJ, Liu, NK, Shields CB, Xu XM. (2016) Anatomical and functional effects of lateral cervical hemicontusion in adult rats. Restorative Neurology and Neuroscience, 34(3): 389-400.

12. Jones KJ, Lovett-Racke AE, Walker CL, Sanders VM. (2015) CD4 + T Cells and Neuroprotection: Relevance to Motoneuron Injury and Disease. J Neuroimmune Pharmacol. 2015 Jul 7. [Epub ahead of print]

13. Walker, MJ*, Walker CL*, Zhang, YP, Shields, CB, and Xu XM. (2015) Surgical stabilization of the cervical spinal cord for unilateral C5 contusion injury using the NYU/MASCIS impactor. Journal of Visualized Experiments. (95), e50149, doi:10.3791/50149. *, co-first author.

14. Deng, LX, Walker, CL, and Xu, XM. (2015) Schwann Cell-Mediated Axonal Regeneration in the Central Nervous System, In: Neural Regeneration, So, KF and Xu, XM (eds.) Science Press. In Press.

15. Walker, CL, Wang XF, Bullis, CL, Liu, NK, Lu, QB, Fry, C, Deng, LX, Xu, XM (2015) Biphasic bisperoxovanadium administration and Schwann cell transplantation for repair after cervical contusive spinal cord injury. Experimental Neurology 264: 163-172. doi: 10.1016/j.expneurol.2014.12.002.

16. Deng, LX, Walker, CL, Xu XM. (2014) Schwann cell transplantation and descending propriospinal regeneration after spinal cord injury. Brain Research. doi:10.1016/j.brainres.2014.09.038.

17. Liu, NK, Zhang, YP, Zou, J, Verhovshek, T, Chen, C, Lu, QB, Walker, CL, Shields, CB, and Xu, XM. (2014) A semicircular controlled cortical impact produces long-term motor and cognitive dysfunction that correlates well with damage to both the sensorimotor cortex and hippocampus. Brain Research. doi:10.1016/j.brainres.2014.05.042.

18. Li, YP*, Walker, CL*, Zhang, YP, Shields, CB, and Xu, XM. (2014) Surgical decompression in acute spinal cord injury: A review of clinical evidence, animal models studies, and potential future directions of investigation. Frontiers in Biology, 9(2):127–136. doi:10.1007/s11515-014-1297-z. *, co-first author.

19. Walker, CL and Xu XM. (2014) PTEN inhibitor bisperoxovanadium protects oligodendrocytes and myelin and prevents neuronal atrophy in adult rats following cervical hemicontusive spinal cord injury. Neuroscience Letters, 573: 64-68. doi:10.1016/j.neulet.2014.02.039.

20. Walker, CL, Liu, NK, and Xu XM. (2013) The role of PTEN/PI3K and MAPK signaling in protection and pathology following CNS injuries. Frontiers in Biology, doi:10.1007/s11515-013-1255-1.

21. Zhang, YP, Walker, MJ, Shields, LBE, Wang, XF, Walker, CL, Xu, XM, and Shields, CB. (2013) Controlled Cervical Laceration Injury in Mice. Journal of Visualized Experiments (75), e50030, doi:10.3791/50030.

22. Liu, NK, Zhang, YP, O’Connor, J, Gianaris, A, Ahuja, SK, Oakes, E, Lu, QB, Verhovshek, T, Walker, CL, Shields, CB Xu, XM. (2012) A bilateral closed-head injury that shows graded brain damage and behavioral deficits in adult mice. Brain Research, doi:10.1016/j.brainres.2012.12.031.

23. Walker, CL, Walker MJ, Liu, NK, Risberg, EC, Gao, X, Chen, J, and Xu XM. (2012) Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and promotes recovery after spinal cord injury, PLoS One, doi:10.1371/journal.pone.0030012.

Titles & Appointments

  • Associate Professor, School of Dentistry
  • Adjunct Associate Professor of Anatomy, Cell Biology & Physiology
  • Assistant Professor, Department of Biomedical &amp
  • Applied Sciences
  • Education
    2013 PhD Indiana University
    2008 MS University of Nebraska
    2005 BGS Indiana University
  • Research

    My research focuses on understanding the progression of tissue pathology following peripheral and central nervous system injuries and diseases, and how pharmacological, cell-based, and combination therapies can improve anatomical and neurological outcome. Cellular and molecular mechanisms of how these therapies act are also of great interest.

  • Awards
    Org: Indiana University School of Dentistry Alumni Association
    Desc: Distinguished Faculty Award for Research
    Scope: School
    Date: 2019-04-03

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