12576-Butler, James

James Butler, PhD, MD

Assistant Professor of Surgery

EH 5th Floor
Indianapolis, IN
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Key Publications

1: Samy KP, Butler JR, Li P, Cooper DKC, Ekser B. Corrigendum to "The Role of
Costimulation Blockade in Solid Organ and Islet Xenotransplantation". J Immunol Res. 2018 Mar 22;2018:6343608. doi: 10.1155/2018/6343608. eCollection 2018. PubMed PMID: 29767012; PubMed Central PMCID: PMC5885337.

2: Samy KP, Butler JR, Li P, Cooper DKC, Ekser B. The Role of Costimulation
Blockade in Solid Organ and Islet Xenotransplantation. J Immunol Res.
2017;2017:8415205. doi: 10.1155/2017/8415205. Epub 2017 Oct 11. Review. Erratum in: J Immunol Res. 2018 Mar 22;2018:6343608. PubMed PMID: 29159187; PubMed Central PMCID: PMC5660816.

3: Ladowski JM, Reyes LM, Martens GR, Butler JR, Wang ZY, Eckhoff DE, Tector M, Tector AJ. Swine Leukocyte Antigen Class II Is a Xenoantigen. Transplantation. 2018 Feb;102(2):249-254. doi: 10.1097/TP.0000000000001924. PubMed PMID: 28846555;
PubMed Central PMCID: PMC5978411.

4: Butler JR, Santos RMN, Martens GR, Ladowski JM, Wang ZY, Li P, Tector M,
Tector AJ. Efficient generation of targeted and controlled mutational events in
porcine cells using nuclease-directed homologous recombination. J Surg Res. 2017 May 15;212:238-245. doi: 10.1016/j.jss.2017.01.025. Epub 2017 Jan 29. PubMed PMID: 28550913.

5: Martens GR, Reyes LM, Butler JR, Ladowski JM, Estrada JL, Sidner RA, Eckhoff DE, Tector M, Tector AJ. Humoral Reactivity of Renal Transplant-Waitlisted Patients to Cells From GGTA1/CMAH/B4GalNT2, and SLA Class I Knockout Pigs. Transplantation. 2017 Apr;101(4):e86-e92. doi: 10.1097/TP.0000000000001646.
PubMed PMID: 28114170.

6: Butler JR, Tector AJ. CRISPR genome-editing: A medical revolution. J Thorac
Cardiovasc Surg. 2017 Feb;153(2):488-491. doi: 10.1016/j.jtcvs.2016.08.067. Epub 2016 Nov 21. PubMed PMID: 28104200.

7: Butler JR, Skill NJ, Priestman DL, Platt FM, Li P, Estrada JL, Martens GR,
Ladowski JM, Tector M, Tector AJ. Silencing the porcine iGb3s gene does not
affect Galα3Gal levels or measures of anticipated pig-to-human and pig-to-primate acute rejection. Xenotransplantation. 2016 Mar;23(2):106-16. doi:
10.1111/xen.12217. Epub 2016 Jan 11. PubMed PMID: 27106872.

8: Butler JR, Martens GR, Estrada JL, Reyes LM, Ladowski JM, Galli C, Perota A,
Cunningham CM, Tector M, Joseph Tector A. Silencing porcine genes significantly reduces human-anti-pig cytotoxicity profiles: an alternative to direct complement regulation. Transgenic Res. 2016 Oct;25(5):751-9. doi: 10.1007/s11248-016-9958-0. Epub 2016 Apr 21. PubMed PMID: 27100221.

9: Butler JR, Ahmad SA, Katz MH, Cioffi JL, Zyromski NJ. A systematic review of the role of periadventitial dissection of the superior mesenteric artery in
affecting margin status after pancreatoduodenectomy for pancreatic
adenocarcinoma. HPB (Oxford). 2016 Apr;18(4):305-11. doi:
10.1016/j.hpb.2015.11.009. Epub 2016 Feb 1. Review. PubMed PMID: 27037198; PubMed
Central PMCID: PMC4814605.

10: Butler JR, Paris LL, Blankenship RL, Sidner RA, Martens GR, Ladowski JM, Li P, Estrada JL, Tector M, Tector AJ. Silencing Porcine CMAH and GGTA1 Genes
Significantly Reduces Xenogeneic Consumption of Human Platelets by Porcine
Livers. Transplantation. 2016 Mar;100(3):571-6. doi: 10.1097/TP.0000000000001071.
PubMed PMID: 26906939; PubMed Central PMCID: PMC4770806.

11: Wang ZY, Li P, Butler JR, Blankenship RL, Downey SM, Montgomery JB, Nagai S, Estrada JL, Tector MF, Tector AJ. Immunogenicity of Renal Microvascular Endothelial Cells From Genetically Modified Pigs. Transplantation. 2016 Mar;100(3):533-7. doi: 10.1097/TP.0000000000001070. PubMed PMID: 26906938.

12: Butler JR, Wang ZY, Martens GR, Ladowski JM, Li P, Tector M, Tector AJ.
Modified glycan models of pig-to-human xenotransplantation do not enhance the human-anti-pig T cell response. Transpl Immunol. 2016 Mar;35:47-51. doi:
10.1016/j.trim.2016.02.001. Epub 2016 Feb 9. PubMed PMID: 26873419.

13: Butler JR, Fohtung TM, Sandrasegaran K, Ceppa EP, House MG, Nakeeb A, Schmidt CM, Zyromski NJ. The natural history of pancreatic lipoma: Does it need observation. Pancreatology. 2016 Jan-Feb;16(1):95-8. doi:
10.1016/j.pan.2015.11.005. Epub 2015 Nov 27. PubMed PMID: 26682506.

14: Butler JR, Martens GR, Li P, Wang ZY, Estrada JL, Ladowski JM, Tector M,
Tector AJ. The fate of human platelets exposed to porcine renal endothelium: a
single-pass model of platelet uptake in domestic and genetically modified porcine organs. J Surg Res. 2016 Feb;200(2):698-706. doi: 10.1016/j.jss.2015.08.034. Epub 2015 Aug 28. PubMed PMID: 26375504.

15: Butler JR, Ladowski JM, Martens GR, Tector M, Tector AJ. Recent advances in genome editing and creation of genetically modified pigs. Int J Surg. 2015
Nov;23(Pt B):217-222. doi: 10.1016/j.ijsu.2015.07.684. Epub 2015 Jul 29. Review. PubMed PMID: 26231992.

16: Paris LL, Estrada JL, Li P, Blankenship RL, Sidner RA, Reyes LM, Montgomery JB, Burlak C, Butler JR, Downey SM, Wang ZY, Tector M, Tector AJ. Reduced human platelet uptake by pig livers deficient in the asialoglycoprotein receptor 1 protein. Xenotransplantation. 2015 May-Jun;22(3):203-10. doi: 10.1111/xen.12164. Epub 2015 Feb 27. PubMed PMID: 25728617; PubMed Central PMCID: PMC6017985.

17: Estrada JL, Martens G, Li P, Adams A, Newell KA, Ford ML, Butler JR, Sidner R, Tector M, Tector J. Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes. Xenotransplantation. 2015 May-Jun;22(3):194-202. doi: 10.1111/xen.12161. Epub 2015 Mar 1. PubMed PMID: 25728481; PubMed Central PMCID: PMC4464961.

18: Butler JR, Rogers T, Eckart G, Martens GR, Ceppa EP, House MG, Nakeeb A, Schmidt CM, Zyromski NJ. Is antisecretory therapy after pancreatoduodenectomy necessary? Meta-analysis and contemporary practices of pancreatic surgeons. J Gastrointest Surg. 2015 Apr;19(4):604-12. doi: 10.1007/s11605-015-2765-8. Epub 2015 Feb 18. Review. PubMed PMID: 25691111.

19: Li P, Estrada JL, Burlak C, Montgomery J, Butler JR, Santos RM, Wang ZY,
Paris LL, Blankenship RL, Downey SM, Tector M, Tector AJ. Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide
RNA and carbohydrate selection. Xenotransplantation. 2015 Jan-Feb;22(1):20-31. doi: 10.1111/xen.12131. Epub 2014 Sep 2. PubMed PMID: 25178170.

20: Butler JR, Eckert GJ, Zyromski NJ, Leonardi MJ, Lillemoe KD, Howard TJ.
Natural history of pancreatitis-induced splenic vein thrombosis: a systematic
review and meta-analysis of its incidence and rate of gastrointestinal bleeding.
HPB (Oxford). 2011 Dec;13(12):839-45. doi: 10.1111/j.1477-2574.2011.00375.x. Epub 2011 Oct 12. Review. PubMed PMID: 22081918; PubMed Central PMCID: PMC3244622.

Titles & Appointments

  • Assistant Professor of Surgery
  • Education
    2017 PhD Indiana University
    2011 MD Indiana University
  • Awards
    Org: Alpha Omega Alpha
    Desc: Election to Alpha Omega Alpha is an honor signifying a lasting commitment to scholarship, leadership, professionalism, and service. A lifelong honor, membership in the society confers recognition for a physician's dedication to the profession and art of healing.
    Scope: National

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