12275-Goebel, W
Faculty

W S. Goebel, MD, PHD

Associate Professor of Clinical Pediatrics

Bio

Dr. Goebel has been on the faculty at Indiana University School of Medicine since 2001. As a clinical stem cell transplant physician he takes care of children with a variety of malignant and non-malignant diseases, and served as the Interim Director of the Pediatric Stem Cell Transplantation Program from 2012-2014. Dr. Goebel has a particular interest in cellular therapeutics and gene therapy, and his laboratory background is in gene therapy, submyeloablative conditioning for stem cell transplantation, and mesenchymal stem cell (MSC) biology. He has studied the impairment of stem cell function following ex vivo gene transfer, and potential means to enhance engraftment of transduced hematopoietic stem cells in submyeloablated hosts, laying the foundation for clinical gene therapy studies.

Key Publications

 

Megakaryocytes Enhance Mesenchymal Stromal Cells Proliferation and Inhibit Differentiation. Emmakah AM, Arman HE, Alvarez MB, Childress PJ, Bidwell JP, Goebel WS, Gabriel Chu TM, Kacena MA. J Cell Biochem. 2017 Jul 19. doi: 10.1002/jcb.26289. [Epub ahead of print]

 

 

 

A fast-degrading thiol-acrylate based hydrogel for cranial regeneration. Emmakah AM, Arman HE, Bragg JC, Greene T, Alvarez MB, Childress PJ, Goebel WS, Kacena MA, Lin CC, Chu TM. Biomed Mater. 2017 Mar 17;12(2):025011. doi: 10.1088/1748-605X/aa5f3e.

 

 

 

 

 

Fabrication of Poly-l-lactic Acid/Dicalcium Phosphate Dihydrate Composite Scaffolds with High Mechanical Strength-Implications for Bone Tissue Engineering. Tanataweethum N, Liu WC, Goebel WS, Li D, Chu TM. J Funct Biomater. 2015 Nov 4;6(4):1036-53. doi: 10.3390/jfb6041036.

 

 

 

 

 

FANCA safeguards interphase and mitosis during hematopoiesis in vivo. Abdul-Sater Z, Cerabona D, Potchanant ES, Sun Z, Enzor R, He Y, Robertson K, Goebel WS, Nalepa G. Exp Hematol. 2015 Dec;43(12):1031-1046.e12. doi: 10.1016/j.exphem.2015.08.013. Epub 2015 Sep 11.

 

 

 

 

 

The effect of diluted triple and double antibiotic pastes on dental pulp stem cells and established Enterococcus faecalis biofilm. Sabrah AH, Yassen GH, Liu WC, Goebel WS, Gregory RL, Platt JA. Clin Oral Investig. 2015 Nov;19(8):2059-66. doi: 10.1007/s00784-015-1423-6. Epub 2015 Feb 19.

 

 

 

 

 

Temozolomide-mediated DNA methylation in human myeloid precursor cells: differential involvement of intrinsic and extrinsic apoptotic pathways. Wang H, Cai S, Ernstberger A, Bailey BJ, Wang MZ, Cai W, Goebel WS, Czader MB, Crean C, Suvannasankha A, Shokolenkoc I, Wilson GL, Baluyut AR, Mayo LD, Pollok KE. Clin Cancer Res. 2013 May 15;19(10):2699-709. doi: 10.1158/1078-0432.CCR-12-2671. Epub 2013 Mar 27.

 

 

 

 

 

Effects of DCPD cement chemistry on degradation properties and cytocompatibility: comparison of MCPM/β-TCP and MCPM/HA formulations. Alge DL, Goebel WS, Chu TM. Biomed Mater. 2013 Apr;8(2):025010. doi: 10.1088/1748-6041/8/2/025010. Epub 2013 Feb 22.

 

 

 

 

 

Manufacturing and banking of mesenchymal stem cells. Thirumala S, Goebel WS, Woods EJ. Expert Opin Biol Ther. 2013 May;13(5):673-91. doi: 10.1517/14712598.2013.763925. Epub 2013 Jan 23. Review.

 

Titles & Appointments

  • Associate Professor of Clinical Pediatrics
  • Education
    2001 FEL Indiana University School of Medicine
    2001 FEL Indiana University School of Medicine
    1998 RES Washington University Medical Center
    1998 RES Washington University Medical Center
    1995 MD Indiana University
    1995 PhD Indiana University
    1995 MD Indiana University
    1995 PHD Indiana University
    1995 MD Indiana University
    1995 PHD Indiana University
    1987 BA Earlham College
    1987 BA Earlham College
    1987 BA Earlham College
  • Research

    My clinical and translational research interests currently include development of cellular therapies to enhance hematopoietic stem cell transplantation and reduce regimen-related toxicities, and development of clinical gene therapy protocols. He continues to MSC biology, particularly how to isolate, expand and cryopreserve mesenchymal stem cells from various tissue sources in a cGMP-compliant manner for clinical use.

  • Professional Organizations
    American Society for Blood and Marrow Transplantation
    Children's Oncology Group
    Pediatric Blood and Marrow Transplant Consortium
    Society for Cryobiology
    Tissue Engineering International & Regenerative Medicine Society
  • Board Certifications
    American Board of Pediatrics - Pediatrics
    American Board of Pediatrics - Pediatric Hematology-Oncology
  • Clinical Interests

    Dr. Goebel's clinical/translational research interests include cellular therapies to enhance hematopoietic stem cell transplantation and reduce regimen-related toxicities, and gene therapy for hematopoietic diseases.

  • Awards
    Org: IU, SOM
    Desc: TRUSTEE TEACHING AWARD
    Scope: School
    Date: 2007-01-01

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